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Title: Saltatory formation, sliding and dissolution of ER-PM junctions in migrating cancer cells.
Authors: DINGSDALE, Hayley; OKEKE, Emmanuel; AWAIS, Muhammad; HAYNES, Lee; CRIDDLE, David N.; SUTTON, Robert; TEPIKIN, Alexei V.
Abstract: We demonstrated three novel forms of dynamic behaviour of junctions between the ER (endoplasmic reticulum) and the PM (plasma membrane) inmigrating cancer cells: saltatory formation, long-distance sliding and dissolution. The individual ER-PM junctions formed near the leading edge of migrating cells (usually within 0.5 µm of polymerized actin and close to focal adhesions) and appeared suddenlywithout sliding from the interior of the cell. The long distance sliding and dissolution of ER-PM junctions accompanied the tail withdrawal.
Subjects: ENDOPLASMIC reticulum; CELL membranes; CANCER cells; ACTIN; FOCAL adhesions; DISSOLUTION (Chemistry)
Publication: Biochemical Journal, 2013, Vol 451, Issue 1, p25
ISSN: 0264-6021
Publication type: Academic Journal
DOI: 10.1042/BJ20121864

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Saltatory formation, sliding and dissolution of ER-PM junctions in migrating cancer cells.