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Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans.
- Published in:
- BioMed Research International, 2016, v. 2016, p. 1, doi. 10.1155/2016/9737920
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- Publication type:
- Article
High-speed videography of transparent media using illumination-based multiplexed schlieren.
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- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-23198-6
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- Publication type:
- Article
Gene expression-based in vivo and in vitro prediction of liver toxicity allows compound selection at an early stage of drug development.
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- Journal of Biochemical & Molecular Toxicology, 2011, v. 25, n. 3, p. 183, doi. 10.1002/jbt.20375
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- Publication type:
- Article
FuSe: a tool to move RNA-Seq analyses from chromosomal/gene loci to functional grouping of mRNA transcripts.
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- Bioinformatics, 2021, v. 37, n. 3, p. 375, doi. 10.1093/bioinformatics/btaa735
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- Publication type:
- Article
Establishment of a translational endothelial cell model using directed differentiation of induced pluripotent stem cells from Cynomolgus monkey.
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- Scientific Reports, 2016, p. 35830, doi. 10.1038/srep35830
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- Publication type:
- Article
Identification of Metabolites, Clinical Chemistry Markers and Transcripts Associated with Hepatotoxicity.
- Published in:
- PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0097249
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- Publication type:
- Article
Bioengineered 3D Human Kidney Tissue, a Platform for the Determination of Nephrotoxicity.
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- PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0059219
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- Publication type:
- Article
Phytoestrogen kaempferol (3,4′,5,7-tetrahydroxyflavone) protects PC12 and T47D cells from β-amyloid-induced toxicity.
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- Journal of Neuroscience Research, 1999, v. 57, n. 3, p. 399, doi. 10.1002/(SICI)1097-4547(19990801)57:3<399::AID-JNR12>3.0.CO;2-W
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- Publication type:
- Article
Concurrent isolation of hepatic stem cells and hepatocytes from the human liver.
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- In Vitro Cellular & Developmental Biology Animal, 2020, v. 56, n. 3, p. 253, doi. 10.1007/s11626-020-00433-w
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- Publication type:
- Article
The Sterolgene v0 cDNA microarray: a systemic approach to studies of cholesterol homeostasis and drug metabolism.
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- BMC Genomics, 2008, v. 9, p. 1, doi. 10.1186/1471-2164-9-76
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- Publication type:
- Article
Differential Monocyte Actuation in a Three‐Organ Functional Innate Immune System‐on‐a‐Chip.
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- Advanced Science, 2020, v. 7, n. 13, p. 1, doi. 10.1002/advs.202000323
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- Publication type:
- Article
Characterization of a long-term mouse primary liver 3D tissue model recapitulating innate-immune responses and drug-induced liver toxicity.
- Published in:
- PLoS ONE, 2020, v. 15, n. 7, p. 1, doi. 10.1371/journal.pone.0235745
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- Publication type:
- Article
Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics.
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- Science Translational Medicine, 2019, v. 11, n. 497, p. 1, doi. 10.1126/scitranslmed.aav1386
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- Article
A Model‐Based Workflow to Benchmark the Clinical Cholestasis Risk of Drugs.
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- Clinical Pharmacology & Therapeutics, 2021, v. 110, n. 5, p. 1293, doi. 10.1002/cpt.2406
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- Article
Translational precision medicine: an industry perspective.
- Published in:
- 2021
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- Publication type:
- journal article
Exhaled aerosols and saliva droplets measured in time and 3D space: Quantification of pathogens flow rate applied to SARS‐CoV‐2.
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- Natural Sciences, 2023, v. 3, n. 4, p. 1, doi. 10.1002/ntls.20230007
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- Publication type:
- Article
Culture and Drug Profiling of Patient Derived Malignant Pleural Effusions for Personalized Cancer Medicine.
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- PLoS ONE, 2016, v. 11, n. 8, p. 1, doi. 10.1371/journal.pone.0160807
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- Publication type:
- Article
Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs.
- Published in:
- PLoS ONE, 2016, v. 11, n. 7, p. 1, doi. 10.1371/journal.pone.0159431
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- Publication type:
- Article
Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro.
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- PLoS ONE, 2016, v. 11, n. 7, p. 1, doi. 10.1371/journal.pone.0158674
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- Publication type:
- Article
Optimizing Drug Discovery by Investigative Toxicology: Current and Future Trends.
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- Altex, 2019, v. 36, n. 2, p. 289, doi. 10.14573/altex.1808181
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- Publication type:
- Article
Current Approaches and Future Role of High Content Imaging in Safety Sciences and Drug Discovery.
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- Altex, 2014, v. 31, n. 4, p. 479, doi. 10.14573/altex.1405271
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- Publication type:
- Article
Model-based assessment of erlotinib effect in vitro measured by real-time cell analysis.
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- Journal of Pharmacokinetics & Pharmacodynamics, 2015, v. 42, n. 3, p. 275, doi. 10.1007/s10928-015-9415-3
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- Publication type:
- Article
A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.
- Published in:
- 2018
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- Publication type:
- Letter
Current limitations and future opportunities for prediction of DILI from in vitro.
- Published in:
- Archives of Toxicology, 2017, v. 91, n. 1, p. 131, doi. 10.1007/s00204-016-1874-9
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- Publication type:
- Article
Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail.
- Published in:
- Frontiers in Pharmacology, 2016, v. 7, p. 1, doi. 10.3389/fphar.2016.00443
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- Publication type:
- Article
Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes.
- Published in:
- Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00259-3
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- Publication type:
- Article
The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals.
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- Nuclear Receptor, 2004, v. 2, p. 7, doi. 10.1186/1478-1336-2-7
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- Publication type:
- Article
Temporal Patterns of Novel Circulating Biomarkers in IL-2-mediated Vascular Injury in the Rat.
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- Toxicologic Pathology, 2015, v. 43, n. 7, p. 984, doi. 10.1177/0192623315601245
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- Publication type:
- Article
New Drug Modalities Demand a Refined Preclinical Safety Assessment: A Call for Patient-Relevant Tissue Models.
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- Toxicological Sciences, 2022, v. 189, n. 1, p. 5, doi. 10.1093/toxsci/kfac069
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- Publication type:
- Article
Combining In Vivo and Organotypic In Vitro Approaches to Assess the Human Relevance of Basimglurant (RG7090), a Potential CAR Activator.
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- Toxicological Sciences, 2020, v. 176, n. 2, p. 329, doi. 10.1093/toxsci/kfaa076
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- Publication type:
- Article
Application of Hemodynamic Shear Stress to Endothelial Cell Cultures: The Sine Qua Non For In Vivo Translatability or a Potential Contributing Factor?
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- 2014
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- Publication type:
- Letter to the Editor
A Real-time Impedance-Based Screening Assay for Drug-Induced Vascular Leakage.
- Published in:
- Toxicological Sciences, 2014, v. 138, n. 2, p. 333, doi. 10.1093/toxsci/kft336
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- Publication type:
- Article
Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia.
- Published in:
- PLoS ONE, 2017, v. 12, n. 11, p. 1, doi. 10.1371/journal.pone.0187574
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- Publication type:
- Article