Lack of association between polymorphism of the human cyclic GMP-dependent protein kinase gene and obesity.

Zakharkin, S O; Belay, A T; Fernandez, J R; De Luca, V; Kennedy, J L; Sokolowski, M B; Allison, D B

OBJECTIVE:To investigate whether genetic variation in the cyclic GMP-dependent protein kinase gene (PRKG1) is associated with obesity.METHODS:The study included 143 individuals from New York City area, NY, USA. The subjects were sampled on the basis of body mass index (BMI): obese (BMI ranging from 33.8 to 89.5 kg/m2), and nonobese (BMI ranging from 16.0 to 29.4 kg/m2). The association between C2276T polymorphism in PRKG1 gene and obesity was tested using linear regression analysis.RESULTS:BMI levels were predicted by linear regression models adjusted for demographic factors. An analysis was performed twice: in individuals of all ethnical backgrounds and in European-Americans only. In both cases, genotype did not have a significant effect.CONCLUSION:We found no evidence that the C2276T polymorphism in the PKRG1 gene is associated with obesity.International Journal of Obesity (2005) 29, 872–874. doi:10.1038/sj.ijo.0802973 Published online 10 May 2005

GENETIC polymorphisms; PROTEIN kinases; GENES; OBESITY; PHOSPHOTRANSFERASES; REGRESSION analysis

International Journal of Obesity, 2005, Vol 29, Issue 7, p872

0307-0565

Academic Journal

10.1038/sj.ijo.0802973