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Title

Ulcerative colitis after autologous peripheral blood stem cell transplantation for non-Hodgkin’s lymphoma.

Authors

Koike, K; Kohda, K; Kuga, T; Nakazawa, O; Ando, M; Takayanagi, N; Matsunaga, T; Sakamaki, S; Niitsu, Y

Abstract

A 54-year-old woman with peripheral T cell lymphoma in second complete remission (CR) received an autologous peripheral blood stem cell transplant (PBSCT). Antibiotic-resistant bloody diarrhea, and fever developed 110 days after transplant. Blood and stool cultures were negative. Skin rash was not observed. Barium enema and colonoscopy showed typical features of pancolonic-type ulcerative colitis (UC). Endoscopic biopsies confirmed the diagnosis of UC. Mesalazine and immunosuppressive therapy improved symptoms dramatically. We detected serum antibodies against synthetic tropomyosin (TM) peptide when UC was diagnosed. We postulate that autoimmunity including autoreactive anti-TM antibodies may be involved in the pathogenesis of UC after autologous PBSCT in this patient. Bone Marrow Transplantation (2001) 28, 619–621.

Subjects

ULCERATIVE colitis; AUTOTRANSPLANTATION; STEM cell transplantation; HODGKIN'S disease

Publication

Bone Marrow Transplantation, 2001, Vol 28, Issue 6, p619

ISSN

0268-3369

Publication type

Academic Journal

DOI

10.1038/sj.bmt.1703205

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