Works matching Pregnenolone

Results: 903

Amyloid Beta Peptides Affect Pregnenolone and Pregnenolone Sulfate Levels in PC-12 and SH-SY5Y Cells Depending on Cholesterol.

Published in:

Neurochemical Research, 2016, v. 41, n. 7, p. 1700, doi. 10.1007/s11064-016-1886-0

By:

Calan, Ozlem;
Akan, Pinar;
Cataler, Aysenur;
Dogan, Cumhur;
Kocturk, Semra

Publication type:

Article

Synthesis of [3 α-3H] 17 α-Hydroxy pregnenolone and [3 α-3H] Pregnenolone.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2014, v. 57, n. 1, p. 1, doi. 10.1002/jlcr.3114

By:

Tian, Yuan;
Hong, Yang;
Bonacorsi, Samuel J.;
Balog, Aaron;
Gong, Sharon

Publication type:

Article

Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings.

Published in:

Life (2075-1729), 2024, v. 14, n. 11, p. 1483, doi. 10.3390/life14111483

By:

Gao, Huaze;
Magin, Zachary;
Fogelman, Nia;
Sinha, Rajita;
Angarita, Gustavo A.;
Milivojevic, Verica

Publication type:

Article

The effects of the neurosteroids: pregnenolone, progesterone and dehydroepiandrosterone on muscarinic receptor-induced responses inXenopusoocytes expressing M1 and M3 receptors.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2005, v. 371, n. 3, p. 221, doi. 10.1007/s00210-005-1022-1

By:

Takafumi Horishita;
Kouichiro Minami;
Yasuhito Uezono;
Munehiro Shiraishi;
Junichi Ogata;
Takashi Okamoto;
Tadanori Terada;
Takeyoshi Sata

Publication type:

Article

Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder.

Published in:

Psychopharmacology, 2023, v. 240, n. 1, p. 101, doi. 10.1007/s00213-022-06278-3

By:

Milivojevic, Verica;
Sullivan, Liam;
Tiber, Jessica;
Fogelman, Nia;
Simpson, Christine;
Hermes, Gretchen;
Sinha, Rajita

Publication type:

Article

Proof-of-concept randomized controlled trial of pregnenolone in schizophrenia.

Published in:

Psychopharmacology, 2014, v. 231, n. 17, p. 3647, doi. 10.1007/s00213-014-3673-4

By:

Marx, Christine;
Lee, Jimmy;
Subramaniam, Mythily;
Rapisarda, Attilio;
Bautista, Dianne;
Chan, Edwin;
Kilts, Jason;
Buchanan, Robert;
Wai, Eu;
Verma, Swapna;
Sim, Kang;
Hariram, Jayaraman;
Jacob, Rajesh;
Keefe, Richard;
Chong, Siow

Publication type:

Article

Pregnenolone Sulfate: From Steroid Metabolite to TRP Channel Ligand.

Published in:

Molecules, 2013, v. 18, n. 10, p. 12012, doi. 10.3390/molecules181012012

By:

Harteneck, Christian

Publication type:

Article

Expression of cytochromes P450 3A in mouse lung: effects of dexamethasone and pregnenolone 16α-carbonitrile.

Published in:

Archives of Toxicology, 2003, v. 77, n. 3, p. 145, doi. 10.1007/s00204-002-0426-7

By:

Haag, Muriel;
Fautrel, Alain;
Guillouzo, André;
Frossard, Nelly;
Pons, Françoise

Publication type:

Article

Hydroxylation of pregnenolone and dehydroepiandrosterone by zygomycete Backusella lamprospora VKM F-944: selective production of 7α-OH-DHEA.

Published in:

Applied Microbiology & Biotechnology, 2022, v. 106, n. 2, p. 535, doi. 10.1007/s00253-021-11737-6

By:

Kollerov, Vyacheslav;
Shutov, Andrei;
Kazantsev, Alexey;
Donova, Marina

Publication type:

Article

Endogenous biosynthesis of docosahexaenoic acid (DHA) regulates fish oocyte maturation by promoting pregnenolone production.

Published in:

Zoological Research, 2024, v. 45, n. 1, p. 176, doi. 10.24272/j.issn.2095-8137.2023.032

By:

Yi Li;
Xuehui Li;
Ding Ye;
Ru Zhang;
Chengjie Liu;
Mudan He;
Houpeng Wang;
Wei Hu;
Yonghua Sun

Publication type:

Article

Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia.

Published in:

Neuropsychopharmacology, 2009, v. 34, n. 8, p. 1885, doi. 10.1038/npp.2009.26

By:

Marx, Christine E.;
Keefe, Richard S. E.;
Buchanan, Robert W.;
Hamer, Robert M.;
Kilts, Jason D.;
Bradford, Daniel W.;
Strauss, Jennifer L.;
Naylor, Jennifer C.;
Payne, Victoria M.;
Lieberman, Jeffrey A.;
Savitz, Adam J.;
Leimone, Linda A.;
Dunn, Lawrence;
Porcu, Patrizia;
Morrow, A. Leslie;
Shampine, Lawrence J.

Publication type:

Article

Biocatalytic modifications of pregnenolone by selected filamentous fungi.

Published in:

Biocatalysis & Biotransformation, 2019, v. 37, n. 5, p. 319, doi. 10.1080/10242422.2018.1549237

By:

Kollerov, Vyacheslav V.;
Shutov, Andrei A.;
Kazantsev, Alexey V.;
Donova, Marina V.

Publication type:

Article

Pregnenolone, a cholesterol metabolite, induces glioma cell apoptosis via activating extrinsic and intrinsic apoptotic pathways.

Published in:

Oncology Letters, 2014, v. 8, n. 2, p. 645, doi. 10.3892/ol.2014.2147

By:

XIAO XIAO;
LIJUN CHEN;
YING OUYANG;
WENBO ZHU;
PENGXIN QIU;
XINWEN SU;
YUNLING DOU;
LIPENG TANG;
MIN YAN;
HAIPENG ZHANG;
XIAOXIAO YANG;
DONG XU;
GUANGMEI YAN

Publication type:

Article

Pregnenolone Inhibits Doxorubicin-Induced Cardiac Oxidative Stress, Inflammation, and Apoptosis—Role of Matrix Metalloproteinase 2 and NADPH Oxidase 1.

Published in:

Pharmaceuticals (14248247), 2023, v. 16, n. 5, p. 665, doi. 10.3390/ph16050665

By:

Morsy, Mohamed A.;
Abdel-Gaber, Seham A.;
Mokhemer, Sahar A.;
Kandeel, Mahmoud;
Sedik, Wael F.;
Nair, Anroop B.;
Venugopala, Katharigatta N.;
Khalil, Hany Ezzat;
Al-Dhubiab, Bandar E.;
Mohamed, Mervat Z.

Publication type:

Article

Stimulatory Effects of Propylthiouracil on Pregnenolone Production through Upregulation of Steroidogenic Acute Regulatory Protein Expression in Rat Granulosa Cells.

Published in:

Toxicological Sciences, 2010, v. 118, n. 2, p. 667, doi. 10.1093/toxsci/kfq302

By:

Chen, Mei-Chih;
Wang, Shyi-Wu;
Kan, Shu-Fen;
Tsai, Shiow-Chwen;
Wu, Yu-Ching;
Wang, Paulus S.

Publication type:

Article

p53-Independent Induction of Rat Hepatic Mdm2 following Administration of Phenobarbital and Pregnenolone 16α-Carbonitrile.

Published in:

Toxicological Sciences, 2006, v. 94, n. 2, p. 272, doi. 10.1093/toxsci/kfl115

By:

Nelson, David M.;
Bhaskaran, Vasanthi;
Foster, William R.;
Lehman-McKeeman, Lois D.

Publication type:

Article

Altered levels of synapsin I, dopamine transporter, dynorphin A, and neuropeptide Y in the nucleus accumbens and striatum at post-puberty in rats treated neonatally with pregnenolone or DHEA

Published in:

International Journal of Developmental Neuroscience, 2009, v. 27, n. 6, p. 575, doi. 10.1016/j.ijdevneu.2009.06.005

By:

Muneoka, Katsumasa;
Iwata, Masaaki;
Shirayama, Yukihiko

Publication type:

Article

Pregnenolone protects the liver against doxorubicin-induced cellular injury by anti-inflammatory, antioxidant, and antiapoptotic mechanisms: role of Keap1/Nrf2/HO-1 and P-glycoprotein.

Published in:

European Review for Medical & Pharmacological Sciences, 2023, v. 27, n. 10, p. 4718

By:

MORSY, M. A.;
EL-DALY, M.;
KAMEL, B. A.;
RIFAAI, R. A.;
ABDEL-GABER, S. A.

Publication type:

Article

Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis.

Published in:

Cells (2073-4409), 2020, v. 9, n. 10, p. 2323, doi. 10.3390/cells9102323

By:

Witzig, Melissa;
Grimm, Amandine;
Schmitt, Karen;
Lejri, Imane;
Frank, Stephan;
Brown, Steven A.;
Eckert, Anne

Publication type:

Article

Glibenclamide-pregnenolone derivative has greater hypoglycemic effects and biodistribution than glibenclamide-OH in alloxan-rats.

Published in:

Biomedical Papers of the Medical Faculty of Palacky University in Olomouc, 2012, v. 156, n. 2, p. 122, doi. 10.5507/bp.2012.028

By:

Figueroa-Valverde, Lauro;
Diaz-Cedillo, Francisco;
Lopez-Ramos, Maria;
Garcia-Cervera, Elodia;
Pool-Gomez, Eduardo;
Cardena-Arredondo, Carlos;
Ancona-Leon, Graciela

Publication type:

Article

Using the oocyte donation model to identify early trophoblast pregnenolone production.

Published in:

Journal of Assisted Reproduction & Genetics, 2013, v. 30, n. 5, p. 699, doi. 10.1007/s10815-013-9986-0

By:

Licciardi, Frederick;
Tan, Orkun;
Oh, Cheongeun

Publication type:

Article

Convenient synthesis of new pregnenolone oximinyl oxalate dimers.

Published in:

Chemistry of Natural Compounds, 2008, v. 44, n. 3, p. 315, doi. 10.1007/s10600-008-9051-x

By:

Nahar, L.;
Sarker, S. D.;
Turner, A. B.

Publication type:

Article

Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder.

Published in:

Biomolecules (2218-273X), 2022, v. 12, n. 11, p. 1593, doi. 10.3390/biom12111593

By:

Milivojevic, Verica;
Charron, Lily;
Fogelman, Nia;
Hermes, Gretchen;
Sinha, Rajita

Publication type:

Article

Impact of Intraventricular Human Adipose-Derived Stem Cells Transplantation with Pregnenolone Treatment on Remyelination of Corpus Callosum in A Rat Model of Multiple Sclerosis.

Published in:

Cell Journal (Yakhteh), 2022, v. 24, n. 12, p. 748, doi. 10.22074/cellj.2022.8173

By:

Mardani, Mohammad;
Ganji, Raosul;
Ghasemi, Nazem;
Kazemi, Mohammad;
Razavi, Shahnaz

Publication type:

Article

Pregnenolone sulphate and Zn2+ inhibit recombinant rat GABAA receptor through different channel property.

Published in:

Acta Physiologica, 2006, v. 188, n. 3/4, p. 153, doi. 10.1111/j.1748-1716.2006.01617.x

By:

Wang, M.-D.;
Rahman, M.;
Zhu, D.;
Bäckström, T.

Publication type:

Article

Luteinizing hormone receptor mediates neuronal pregnenolone production via up-regulation of steroidogenic acute regulatory protein expression.

Published in:

Journal of Neurochemistry, 2007, v. 100, n. 5, p. 1329, doi. 10.1111/j.1471-4159.2006.04307.x

By:

Tianbing Liu;
Wimalasena, Jay;
Bowen, Richard L.;
Atwood, Craig S.

Publication type:

Article

Pregnenolone and progesterone production from natural sterols using recombinant strain of Mycolicibacterium smegmatis mc2 155 expressing mammalian steroidogenesis system.

Published in:

Microbial Cell Factories, 2024, v. 23, n. 1, p. 1, doi. 10.1186/s12934-024-02385-2

By:

Karpov, Mikhail;
Strizhov, Nicolai;
Novikova, Ludmila;
Lobastova, Tatyana;
Khomutov, Sergey;
Shutov, Andrei;
Kazantsev, Alexey;
Donova, Marina

Publication type:

Article

Pregnenolone derivatives as potential anti‐lung cancer agents: A combined in silico and in vitro approach.

Published in:

Journal of the Chinese Chemical Society, 2022, v. 69, n. 6, p. 872, doi. 10.1002/jccs.202200040

By:

Sethi, Arun;
Yadav, Priyanka;
Singh, Ranvijay Pratap;
Kumar, Saurabh;
Parveen, Shama;
Singh, Asmita;
Yadav, Astha;
Banerjee, Monisha

Publication type:

Article

Minimizing the effects of multicollinearity in the polynomial regression of age relationships and sex differences in serum levels of pregnenolone sulfate in healthy subjects.

Published in:

Clinical Chemistry & Laboratory Medicine, 2009, v. 47, n. 4, p. 464, doi. 10.1515/CCLM.2009.104

By:

Meloun, Milan;
Hill, Martin;
Včeláková-Havlíková, Helena

Publication type:

Article

Microbial conversion of pregnenolone by some filamentous fungi.

Published in:

Biocatalysis & Biotransformation, 2024, v. 42, n. 2, p. 185, doi. 10.1080/10242422.2022.2150967

By:

Kuru, Ali;
Yildirim, Kudret

Publication type:

Article

LINE-1 ORF-1p enhances the transcription factor activity of pregnenolone X receptor and promotes sorafenib resistance in hepatocellular carcinoma cells.

Published in:

Cancer Management & Research, 2018, v. 10, p. 4421, doi. 10.2147/CMAR.S176088

By:

Chen, Yan;
Zeng, Qinglei;
Liu, Xiufang;
Fu, Junliang;
Zeng, Zhen;
Zhao, Zhiqin;
Liu, Ze;
Bai, Wenlin;
Dong, Zheng;
Liu, Hongjin;
Lu, Xiaoxia;
Zhu, Yunfeng;
Lu, Yinying

Publication type:

Article

Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats.

Published in:

European Journal of Neuroscience, 2001, v. 14, n. 12, p. 2003, doi. 10.1046/j.0953-816X.2001.01817.x

By:

Vallée, M.;
Shen, W.;
Heinrichs, S. C.;
Zorumski, C. F.;
Covey, D. F.;
Koob, G. F.;
Purdy, R. H.

Publication type:

Article

Pregnenolone Sulfate Permeation at the Blood–Brain Barrier is Independent of OATP2B1—In Vivo and In Vitro Insights.

Published in:

Biopharmaceutics & Drug Disposition, 2025, v. 46, n. 1, p. 33, doi. 10.1002/bdd.70002

By:

Taggi, Valerio;
Schäfer, Anima M.;
Oswald, Stefan;
Kinzi, Jonny Hanna;
Seibert, Isabell;
Al‐Khatib, Alaa;
Schwabedissen, Henriette E. Meyer zu

Publication type:

Article

Residues in the first transmembrane domain of the Caenorhabditis elegans GABA(A) receptor confer sensitivity to the neurosteroid pregnenolone sulfate.

Published in:

2006

By:

Wardell, Bryan;
Marik, Purba S.;
Piper, David;
Rutar, Tina;
Jorgensen, Erik M.;
Bamber, Bruce A.

Publication type:

journal article

Pregnenolone, Dehydroepiandrosterone, and Schizophrenia: Alterations and Clinical Trials.

Published in:

CNS Neuroscience & Therapeutics, 2010, v. 16, n. 1, p. 32, doi. 10.1111/j.1755-5949.2009.00118.x

By:

Ritsner, Michael S.

Publication type:

Article

Pregnenolone Sulfate Activates NMDA Receptor Channels.

Published in:

Physiological Research, 2013, v. 62, n. 6, p. 731, doi. 10.33549/physiolres.932558

By:

ADAMUSOVÁ, E.;
CAIS, O.;
VYKLICKÝ, V.;
KUDOVÁ, E.;
CHODOUNSKÁ, H.;
HORÁK, M.;
VYKLICKÝ Jr., L.

Publication type:

Article

CLICK-chemoproteomics and molecular dynamics simulation reveals pregnenolone targets and their binding conformations in Th2 cells.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1229703

By:

Roy, Sougata;
Roy, Sudeep;
Mahata, Bidesh;
Pramanik, Jhuma;
Hennrich, Marco L.;
Gavin, Anne-Claude;
Teichmann, Sarah A.

Publication type:

Article

A post-training intrahippocampal anxiogenic dose of the neurosteroid pregnenolone sulfate impairs passive avoidance retention.

Published in:

Experimental Brain Research, 2008, v. 191, n. 2, p. 123, doi. 10.1007/s00221-008-1506-6

By:

Martín-García, E.;
Pallarés, M.

Publication type:

Article

Supraoptic Oxytocin and Vasopressin Neurones Show Differential Sensitivity to the Neurosteroid Pregnenolone Sulphate.

Published in:

Journal of Neuroendocrinology, 1998, v. 10, n. 11, p. 829, doi. 10.1046/j.1365-2826.1998.00270.x

By:

Richardson;
Wakerley

Publication type:

Article

Effects of pregnenolone intervention on the cholinergic system and synaptic protein 1 in aged rats.

Published in:

International Journal of Neuroscience, 2014, v. 124, n. 2, p. 117, doi. 10.3109/00207454.2013.824437

By:

Bu, Jimei;
Zu, Hengbing

Publication type:

Article

Pregnenolone Sulfate, a Naturally Occurring Excitotoxin Involved in Delayed Retinal Cell Death.

Published in:

Journal of Neurochemistry, 2000, v. 74, n. 6, p. 2380, doi. 10.1046/j.1471-4159.2000.0742380.x

By:

Cascio, C.;
Guarneri, R.;
Russo, D.;
De Leo, G.;
Guarneri, M.;
Piccoli, F.;
Guarneri, P.

Publication type:

Article

Effects of genetic polymorphisms on the sulfation of dehydroepiandrosterone and pregnenolone by human cytosolic sulfotransferase SULT2A1.

Published in:

Biochemistry & Cell Biology, 2018, v. 96, n. 5, p. 655, doi. 10.1139/bcb-2017-0341

By:

Abunnaja, Maryam S.;
Alherz, Fatemah A.;
El Daibani, Amal A.;
Bairam, Ahsan F.;
Rasool, Mohammed I.;
Gohal, Saud A.;
Kurogi, Katsuhisa;
Suiko, Masahito;
Sakakibara, Yoichi;
Liu, Ming-Cheh

Publication type:

Article

Gestation Length in Rabbits--Effect of Aminoglutethimide Phosphate Dexamethasone, Pregnenolone and Progesterone

Published in:

Journal of Animal Science, 1976, v. 42, n. 1, p. 131

By:

First, N. L.;
Torres, Ciro A. A.

Publication type:

Article

MicroRNA-140-3p enhances the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting pregnenolone X receptor.

Published in:

OncoTargets & Therapy, 2018, v. 11, p. 5885, doi. 10.2147/OTT.S179509

By:

Li, Jiaqi;
Zhao, Jing;
Wang, Huan;
Li, Xiaohan;
Liu, Aixia;
Qin, Qin;
Li, Boan

Publication type:

Article

Addiction: Pregnenolone limits effects of cannabis.

Published in:

Nature Reviews Neuroscience, 2014, v. 15, n. 2, p. 66, doi. 10.1038/nrn3681

By:

Welberg, Leonie

Publication type:

Article

Pregnenolone sulfate as a modulator of synaptic plasticity.

Published in:

Psychopharmacology, 2014, v. 231, n. 17, p. 3537, doi. 10.1007/s00213-014-3643-x

By:

Smith, Conor;
Gibbs, Terrell;
Farb, David

Publication type:

Article

Synthesis of aminium 23,24,24-tricyano-3β-hydroxy-20-oxo-21-nor-17β-cholane-5,21-dien-24-ides from tetracyanoethylated pregnenolone.

Published in:

Russian Journal of Organic Chemistry, 2017, v. 53, n. 6, p. 946, doi. 10.1134/S1070428017060227

By:

Belikov, M.;
Ershov, O.

Publication type:

Article

Reactions of pregnenolone and 16-dehydropregnenolone acetate with tetracyanoethylene.

Published in:

Russian Journal of Organic Chemistry, 2010, v. 46, n. 7, p. 1090, doi. 10.1134/S1070428010070225

By:

Belikov, M. Yu.;
Ershov, O. V.;
Eremkin, A. V.;
Kayukov, Ya. S.;
Nasakin, O. E.

Publication type:

Article

A Randomized, Double-Blind, Placebo-Controlled Trial of Pregnenolone for Bipolar Depression.

Published in:

Neuropsychopharmacology, 2014, v. 39, n. 12, p. 2867, doi. 10.1038/npp.2014.138

By:

Brown, E Sherwood;
Park, John;
Marx, Christine E;
Hynan, Linda S;
Gardner, Claire;
Davila, Domingo;
Nakamura, Alyson;
Sunderajan, Prabha;
Lo, Alexander;
Holmes, Traci

Publication type:

Article

A Neuroactive Steroid, Pregnenolone, Alters the Striatal Dopaminergic Tone before and after Puberty.

Published in:

Neuroendocrinology, 2002, v. 75, n. 5, p. 288, doi. 10.1159/000057338

By:

Muneoka, Katsumasa T.;
Takigawa, Morikuni

Publication type:

Article