Learning accurate personalized survival models for predicting hospital discharge and mortality of COVID-19 patients.

Kumar, Neeraj; Qi, Shi-ang; Kuan, Li-Hao; Sun, Weijie; Zhang, Jianfei; Greiner, Russell

Since it emerged in December of 2019, COVID-19 has placed a huge burden on medical care in countries throughout the world, as it led to a huge number of hospitalizations and mortalities. Many medical centers were overloaded, as their intensive care units and auxiliary protection resources proved insufficient, which made the effective allocation of medical resources an urgent matter. This study describes learned survival prediction models that could help medical professionals make effective decisions regarding patient triage and resource allocation. We created multiple data subsets from a publicly available COVID-19 epidemiological dataset to evaluate the effectiveness of various combinations of covariates—age, sex, geographic location, and chronic disease status—in learning survival models (here, "Individual Survival Distributions"; ISDs) for hospital discharge and also for death events. We then supplemented our datasets with demographic and economic information to obtain potentially more accurate survival models. Our extensive experiments compared several ISD models, using various measures. These results show that the "gradient boosting Cox machine" algorithm outperformed the competing techniques, in terms of these performance evaluation metrics, for predicting both an individual's likelihood of hospital discharge and COVID-19 mortality. Our curated datasets and code base are available at our Github repository for reproducing the results reported in this paper and for supporting future research.

SURVIVAL analysis (Biometry); HOSPITAL admission & discharge; HOSPITAL mortality; INTENSIVE care units; BURDEN of care; COVID-19; MEDICAL care

Scientific Reports, 2022, Vol 12, Issue 1, p1

2045-2322

Academic Journal

10.1038/s41598-022-08601-6