Works matching AU Irwin, Nigel

Results: 75

RYGB surgery has modest effects on intestinal morphology and gut hormone populations in the bypassed biliopancreatic limb but causes reciprocal changes in GLP-2 and PYY in the alimentary limb.

Published in:

PLoS ONE, 2023, v. 18, n. 5, p. 1, doi. 10.1371/journal.pone.0286062

By:

Sridhar, Ananyaa;
Khan, Dawood;
Elliott, Jessie A.;
Naughton, Violetta;
Flatt, Peter R.;
Irwin, Nigel;
Moffett, Charlotte R.

Publication type:

Article

Development of a First‐in‐Class Unimolecular Dual GIP/GLP‐2 Analogue, GL‐0001, for the Treatment of Bone Fragility.

Published in:

Journal of Bone & Mineral Research, 2023, v. 38, n. 5, p. 733, doi. 10.1002/jbmr.4792

By:

Gobron, Benoit;
Couchot, Malory;
Irwin, Nigel;
Legrand, Erick;
Bouvard, Béatrice;
Mabilleau, Guillaume

Publication type:

Article

Enteroendocrine K Cells Exert Complementary Effects to Control Bone Quality and Mass in Mice.

Published in:

Journal of Bone & Mineral Research, 2020, v. 35, n. 7, p. 1363, doi. 10.1002/jbmr.4004

By:

Gobron, Benoît;
Bouvard, Béatrice;
Vyavahare, Sagar;
Blom, Liv VV;
Pedersen, Kristian K;
Windeløv, Johanne A;
Boer, Geke A;
Harada, Norio;
Zhang, Sheng;
Shimazu‐Kuwahara, Satoko;
Wice, Burton;
Inagaki, Nobuya;
Legrand, Erick;
Flatt, Peter R;
Chappard, Daniel;
Hartmann, Bolette;
Holst, Jens J;
Rosenkilde, Mette M;
Irwin, Nigel;
Mabilleau, Guillaume

Publication type:

Article

Individual and combined effects of GIP and xenin on differentiation, glucose uptake and lipolysis in 3T3-L1 adipocytes.

Published in:

Biological Chemistry, 2020, v. 401, n. 11, p. 1293, doi. 10.1515/hsz-2020-0195

By:

English, Andrew;
Craig, Sarah L.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Locally produced xenin and the neurotensinergic system in pancreatic islet function and β-cell survival.

Published in:

Biological Chemistry, 2018, v. 399, n. 1, p. 79, doi. 10.1515/hsz-2017-0136

By:

Khan, Dawood;
Vasu, Srividya;
Moffett, R. Charlotte;
Gault, Victor A.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Effects of short-term chemical ablation of glucagon signalling by peptide-based glucagon receptor antagonists on insulin secretion and glucose homeostasis in mice.

Published in:

Biological Chemistry, 2014, v. 395, n. 4, p. 433, doi. 10.1515/hsz-2013-0224

By:

Franklin, Zara J.;
O'Harte, Finbarr P.M.;
Irwin, Nigel

Publication type:

Article

Insulin modulates glucose-dependent insulinotropic polypeptide (GIP) secretion from enteroendocrine K cells in rats.

Published in:

Biological Chemistry, 2011, v. 392, n. 10, p. 909, doi. 10.1515/BC.2011.176

By:

Irwin, Nigel;
Francis, Jacqueline M.E.;
Flatt, Peter R.

Publication type:

Article

Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes.

Published in:

Biological Chemistry, 2009, v. 390, n. 1, p. 75, doi. 10.1515/BC.2009.002

By:

Irwin, Nigel;
McClean, Paula L.;
Patterson, Steven;
Hunter, Kerry;
Flatt, Peter R.

Publication type:

Article

Sub-chronic administration of the 11β-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity.

Published in:

Biological Chemistry, 2008, v. 389, n. 4, p. 441, doi. 10.1515/BC.2008.049

By:

Taylor, Ashley;
Irwin, Nigel;
McKillop, Aine M.;
Flatt, Peter R.;
Gault, Victor A.

Publication type:

Article

Effects of gastric inhibitory polypeptide (GIP) and related analogues on glucagon release at normo- and hyperglycaemia in Wistar rats and isolated islets.

Published in:

Biological Chemistry, 2008, v. 389, n. 2, p. 189, doi. 10.1515/BC.2008.019

By:

Cassidy, Roslyn S.;
Irwin, Nigel;
R. Flatt, Peter

Publication type:

Article

Nonclassical Islet Peptides: Pancreatic and Extrapancreatic Actions.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2019, v. 12, p. N.PAG, doi. 10.1177/1179551419888871

By:

English, Andrew;
Irwin, Nigel

Publication type:

Article

Effects of 2 Novel PYY(1-36) Analogues, (P 3 L 31 P 34)PYY(1-36) and PYY(1-36)(Lys 12 PAL), on Pancreatic Beta-Cell Function, Growth, and Survival.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2019, v. 12, p. N.PAG, doi. 10.1177/1179551419855626

By:

Lafferty, Ryan A;
Gault, Victor A;
Flatt, Peter R;
Irwin, Nigel

Publication type:

Article

Effects of 2 Novel PYY(1-36) Analogues, (P 3 L 31 P 34)PYY(1-36) and PYY(1-36)(Lys 12 PAL), on Pancreatic Beta-Cell Function, Growth, and Survival.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2019, v. 12, p. N.PAG, doi. 10.1177/1179551419855626

By:

Lafferty, Ryan A;
Gault, Victor A;
Flatt, Peter R;
Irwin, Nigel

Publication type:

Article

Stable Incretin Mimetics Counter Rapid Deterioration of Bone Quality in Type 1 Diabetes Mellitus.

Published in:

Journal of Cellular Physiology, 2015, v. 230, n. 12, p. 3009, doi. 10.1002/jcp.25033

By:

Mansur, Sity Aishah;
Mieczkowska, Aleksandra;
Bouvard, Béatrice;
Flatt, Peter R.;
Chappard, Daniel;
Irwin, Nigel;
Mabilleau, Guillaume

Publication type:

Article

The GLP-1 Receptor Agonist Exenatide Ameliorates Bone Composition and Tissue Material Properties in High Fat Fed Diabetic Mice.

Published in:

Frontiers in Endocrinology, 2019, p. N.PAG, doi. 10.3389/fendo.2019.00051

By:

Mansur, Sity Aishah;
Mieczkowska, Aleksandra;
Flatt, Peter R.;
Chappard, Daniel;
Irwin, Nigel;
Mabilleau, Guillaume

Publication type:

Article

Novel enzyme‐resistant pancreatic polypeptide analogs evoke pancreatic beta‐cell rest, enhance islet cell turnover, and inhibit food intake in mice.

Published in:

Biofactors, 2024, v. 50, n. 6, p. 1101, doi. 10.1002/biof.2059

By:

Zhu, Wuyun;
Tanday, Neil;
Lafferty, Ryan A.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Biological Activity and Antidiabetic Potential of C-Terminal Octapeptide Fragments of the Gut-Derived Hormone Xenin.

Published in:

PLoS ONE, 2016, v. 11, n. 3, p. 1, doi. 10.1371/journal.pone.0152818

By:

Martin, Christine M.;
Parthsarathy, Vadivel;
Hasib, Annie;
Ng, Ming T.;
McClean, Stephen;
Flatt, Peter R.;
Gault, Victor A.;
Irwin, Nigel

Publication type:

Article

Have we got the guts to maintain target weight?

Published in:

Acta Physiologica, 2023, v. 238, n. 1, p. 1, doi. 10.1111/apha.13961

By:

Irwin, Nigel

Publication type:

Article

An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice.

Published in:

Diabetologia, 2017, v. 60, n. 3, p. 541, doi. 10.1007/s00125-016-4186-y

By:

Hasib, Annie;
Ng, Ming;
Gault, Victor;
Khan, Dawood;
Parthsarathy, Vadivel;
Flatt, Peter;
Irwin, Nigel

Publication type:

Article

Sequential induction of beta cell rest and stimulation using stable GIP inhibitor and GLP-1 mimetic peptides improves metabolic control in C57BL/KsJ db/db mice.

Published in:

Diabetologia, 2015, v. 58, n. 9, p. 2144, doi. 10.1007/s00125-015-3653-1

By:

Pathak, Varun;
Vasu, Srividya;
Gault, Victor;
Flatt, Peter;
Irwin, Nigel

Publication type:

Article

A novel DPP IV-resistant C-terminally extended glucagon analogue exhibits weight-lowering and diabetes-protective effects in high-fat-fed mice mediated through glucagon and GLP-1 receptor activation.

Published in:

Diabetologia, 2014, v. 57, n. 9, p. 1927, doi. 10.1007/s00125-014-3296-7

By:

Lynch, Aisling;
Pathak, Nupur;
Pathak, Varun;
O'Harte, Finbarr;
Flatt, Peter;
Irwin, Nigel;
Gault, Victor

Publication type:

Article

(D-Ser2)Oxm[Lys38-γ-glu-PAL] improves hippocampal gene expression and cognition in a mouse model of type 1 diabetes.

Published in:

Journal of Experimental & Integrative Medicine, 2016, v. 6, n. 1, p. 1, doi. 10.5455/jeim.050216.br.027

By:

Pathak, Nupur Madhur;
Irwin, Nigel;
Pathak, Varun;
Gault, Victor Alan;
Flatt, Peter Raymond

Publication type:

Article

Synthesis and Evaluation of a Series of Long-Acting Glucagon-Like Peptide-1 (GLP-1) Pentasaccharide Conjugates for the Treatment of Type 2 Diabetes.

Published in:

ChemMedChem, 2015, v. 10, n. 8, p. 1424, doi. 10.1002/cmdc.201500140

By:

Irwin, Nigel;
Patterson, Steven;
de Kort, Martin;
Moffett, R. Charlotte;
Wisse, Jeffry A. J.;
Dokter, Wim H. A.;
Bos, Ebo S.;
Miltenburg, André M. M.;
Flatt, Peter R.

Publication type:

Article

Erratum. A Novel CCK-8/GLP-1 Hybrid Peptide Exhibiting Prominent Insulinotropic, Glucose-Lowering, and Satiety Actions With Significant Therapeutic Potential in High-Fat-Fed Mice. Diabetes 2015;64:2996-3009.

Published in:

2016

By:

Irwin, Nigel;
Pathak, Varun;
Flatt, Peter R

Publication type:

journal article

Short-term CFTR inhibition reduces islet area in C57BL/6 mice.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-47745-w

By:

Khan, Dawood;
Kelsey, Ryan;
Maheshwari, Rashmi R.;
Stone, Virginia M.;
Hasib, Annie;
Manderson Koivula, Fiona N.;
Watson, Aoife;
Harkin, Stephen;
Irwin, Nigel;
Shaw, James A.;
McClenaghan, Neville H.;
Venglovecz, Viktória;
Ébert, Attila;
Flodström-Tullberg, Malin;
White, Michael G.;
Kelly, Catriona

Publication type:

Article

Effects of anti-diabetic drugs on bone metabolism.

Published in:

Expert Review of Endocrinology & Metabolism, 2015, v. 10, n. 6, p. 663, doi. 10.1586/17446651.2015.1077697

By:

Mabilleau, Guillaume;
Chappard, Daniel;
Flatt, Peter R;
Irwin, Nigel

Publication type:

Article

Metabolic effects of sub-chronic ablation of the incretin receptors by daily administration of (Pro3)GIP and exendin(9–39)amide in obese diabetic ( ob/ob) mice.

Published in:

Biological Chemistry, 2007, v. 388, n. 2, p. 221, doi. 10.1515/BC.2007.024

By:

Parker, Jeremy C.;
Irwin, Nigel;
Lavery, Kerry S.;
Green, Brian D.;
O'Harte, Finbarr P. M.;
Gault, Victor A.;
Flatt, Peter R.

Publication type:

Article

Characterisation and glucoregulatory actions of a novel acylated form of the (Pro3)GIP receptor antagonist in type 2 diabetes.

Published in:

Biological Chemistry, 2007, v. 388, n. 2, p. 173, doi. 10.1515/BC.2007.019

By:

Gault, Victor A.;
Hunter, Kerry;
Irwin, Nigel;
Greer, Brett;
Green, Brian D.;
Harriott, Patrick;
O'Harte, Finbarr P. M.;
Flatt, Peter R.

Publication type:

Article

Antidiabetic potential of two novel fatty acid derivatised, N-terminally modified analogues of glucose-dependent insulinotropic polypeptide (GIP): N-AcGIP(LysPAL16) and N-AcGIP(LysPAL37).

Published in:

Biological Chemistry, 2005, v. 386, n. 7, p. 679, doi. 10.1515/BC.2005.079

By:

Irwin, Nigel;
Gault, Victor A.;
Green, Brian D.;
Greer, Brett;
Harriott, Patrick;
Bailey, Clifford J.;
Flatt, Peter R.;
O'Harte, Finbarr P.M.

Publication type:

Article

Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice.

Published in:

Biological Chemistry, 2004, v. 385, n. 9, p. 845, doi. 10.1515/BC.2004.110

By:

Irwin, Nigel;
Gault, Victor A.;
Green, Brian D.;
Greer, Brett;
McCluskey, Jane T.;
Harriott, Patrick;
O'Harte, Finbarr P. M.;
Flatt, Peter R.

Publication type:

Article

Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala8 -substituted GLP-1 analogues.

Published in:

Biological Chemistry, 2004, v. 385, n. 2, p. 169, doi. 10.1515/BC.2004.035

By:

Green, Brian D.;
Gault, Victor A.;
Mooney, Mark H.;
Irwin, Nigel;
Harriott, Patrick;
Greer, Brett;
Bailey, Cliff J.;
O'Harte, Finbarr P. M.;
Flatt, Peter R.

Publication type:

Article

Metabolic Stability, Receptor Binding, cAMP Generation, Insulin Secretion and Antihyperglycaemic Activity of Novel N-Terminal Glu[sup9] -Substituted Analogues of Glucagon-Like Peptide-1.

Published in:

Biological Chemistry, 2003, v. 384, n. 12, p. 1543, doi. 10.1515/BC.2003.171

By:

Green, Brian D.;
Gault, Victor A.;
Irwin, Nigel;
Mooney, Mark H.;
Bailey, Clifford J.;
Harriott, Patrick;
Greer, Brett;
Flatt, Peter R.;
O'Harte, Finbarr P. M.

Publication type:

Article

Enzymatically stable analogue of the gut‐derived peptide xenin on beta‐cell transdifferentiation in high fat fed and insulin‐deficient Ins1Cre/+;Rosa26‐eYFP mice.

Published in:

Diabetes/Metabolism Research & Reviews, 2021, v. 37, n. 3, p. 1, doi. 10.1002/dmrr.3384

By:

Tanday, Neil;
Moffett, R. Charlotte;
Gault, Victor A.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Exendin-4(Lys27 PAL)/gastrin/xenin-8-Gln: A novel acylated GLP-1/gastrin/xenin hybrid peptide that improves metabolic status in obese-diabetic (ob/ob) mice.

Published in:

2019

By:

Hasib, Annie;
Ng, Ming T.;
Tanday, Neil;
Craig, Sarah L.;
Gault, Victor A.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

journal article

Emerging therapeutic potential for xenin and related peptides in obesity and diabetes.

Published in:

2018

By:

Craig, Sarah L.;
Gault, Victor A.;
Irwin, Nigel

Publication type:

journal article

Positive effects of GLP-1 receptor activation with liraglutide on pancreatic islet morphology and metabolic control in C57BL/KsJ db/ db mice with degenerative diabetes.

Published in:

Diabetes/Metabolism Research & Reviews, 2015, v. 31, n. 3, p. 248, doi. 10.1002/dmrr.2608

By:

Moffett, Rachel Charlotte;
Patterson, Steven;
Irwin, Nigel;
Flatt, Peter R.

Publication type:

Article

Comparison of the anti-diabetic effects of GIP- and GLP-1-receptor activation in obese diabetic ( ob/ob) mice: studies with DPP IV resistant N-AcGIP and exendin(1-39)amide.

Published in:

Diabetes/Metabolism Research & Reviews, 2007, v. 23, n. 7, p. 572, doi. 10.1002/dmrr.729

By:

Irwin, Nigel;
McClean, Paula L.;
Cassidy, Roslyn S.;
O'Harte, Finbarr P. M.;
Green, Brian D.;
Gault, Victor A.;
Harriott, Patrick;
Flatt, Peter R.

Publication type:

Article

Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic ( ob/ob) mice.

Published in:

Journal of Peptide Science, 2007, v. 13, n. 6, p. 400, doi. 10.1002/psc.861

By:

Irwin, Nigel;
McClean, Paula L.;
Flatt, Peter R.

Publication type:

Article

Gut-Derived Peptide Hormone Analogues and Potential Treatment of Bone Disorders in Obesity and Diabetes Mellitus.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2024, p. 1, doi. 10.1177/11795514241238059

By:

Ali, Asif;
Flatt, Peter R;
Irwin, Nigel

Publication type:

Article

Potential Therapeutic Role for Apelin and Related Peptides in Diabetes: An Update.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2022, p. 1, doi. 10.1177/11795514221074679

By:

Palmer, Ethan S;
Irwin, Nigel;
O'Harte, Finbarr PM

Publication type:

Article

Potential Therapeutic Role for Apelin and Related Peptides in Diabetes: An Update.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2022, v. 15, p. 1, doi. 10.1177/11795514221074679

By:

Palmer, Ethan S.;
Irwin, Nigel;
O'Harte, Finbarr P. M.

Publication type:

Article

Xenin and Related Peptides: Potential Therapeutic Role in Diabetes and Related Metabolic Disorders.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2021, p. 1, doi. 10.1177/11795514211043868

By:

Craig, Sarah L;
Irwin, Nigel;
Gault, Victor A

Publication type:

Article

Therapeutic Potential of Peptides Derived from Animal Venoms: Current Views and Emerging Drugs for Diabetes.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2021, p. 1, doi. 10.1177/11795514211006071

By:

Coulter-Parkhill, Aimee;
McClean, Stephen;
Gault, Victor A;
Irwin, Nigel

Publication type:

Article

Beneficial impact of Ac3IV, an AVP analogue acting specifically at V1a and V1b receptors, on diabetes islet morphology and transdifferentiation of alpha- and beta-cells.

Published in:

PLoS ONE, 2021, v. 16, n. 12, p. 1, doi. 10.1371/journal.pone.0261608

By:

Mohan, Shruti;
Lafferty, Ryan;
Tanday, Neil;
Flatt, Peter R.;
Moffett, R. Charlotte;
Irwin, Nigel

Publication type:

Article

Sitagliptin Alters Bone Composition in High-Fat-Fed Mice.

Published in:

2019

By:

Mansur, Sity Aishah;
Mieczkowska, Aleksandra;
Flatt, Peter R.;
Chappard, Daniel;
Irwin, Nigel;
Mabilleau, Guillaume

Publication type:

journal article

Dopamine signalling in pancreatic islet cells and role in adaptations to metabolic stress.

Published in:

Journal of Pharmacy & Pharmacology, 2024, v. 76, n. 7, p. 861, doi. 10.1093/jpp/rgae049

By:

Sridhar, Ananyaa;
Flatt, Peter R;
Draper, Matthew;
Tarasov, Andrei I;
Moffett, R Charlotte;
Irwin, Nigel;
Khan, Dawood

Publication type:

Article

Effects of artemether on pancreatic islet morphology, islet cell turnover and α-cell transdifferentiation in insulin-deficient GluCreERT2;ROSA26-eYFP diabetic mice.

Published in:

Journal of Pharmacy & Pharmacology, 2022, v. 74, n. 12, p. 1758, doi. 10.1093/jpp/rgac075

By:

Sarnobat, Dipak;
Lafferty, Ryan A;
Charlotte Moffett, R;
Tarasov, Andrei I;
Flatt, Peter R;
Irwin, Nigel

Publication type:

Article

Effect of poly(ethylene glycol) content and formulation parameters on particulate properties and intraperitoneal delivery of insulin from PLGA nanoparticles prepared using the double-emulsion evaporation procedure.

Published in:

Pharmaceutical Development & Technology, 2018, v. 23, n. 4, p. 370, doi. 10.1080/10837450.2017.1295066

By:

Haggag, Yusuf A.;
Faheem, Ahmed M.;
Tambuwala, Murtaza M.;
Osman, Mohamed A.;
El-Gizawy, Sanaa A.;
O’Hagan, Barry;
Irwin, Nigel;
McCarron, Paul A.

Publication type:

Article

Benefits of Sustained Upregulated Unimolecular GLP-1 and CCK Receptor Signalling in Obesity-Diabetes.

Published in:

Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2021.674704

By:

Tanday, Neil;
English, Andrew;
Lafferty, Ryan A.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Gastric Inhibitory Polypeptide (GIP) Is Selectively Decreased in the Roux-Limb of Dietary Obese Mice after RYGB Surgery.

Published in:

PLoS ONE, 2015, v. 10, n. 8, p. 1, doi. 10.1371/journal.pone.0134728

By:

Zhou, Jiaqiang;
Hao, Zheng;
Irwin, Nigel;
Berthoud, Hans-Rudolf;
Ye, Jianping

Publication type:

Article