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- Title
Central retinal microvasculature damage is associated with orthostatic hypotension in Parkinson's disease.
- Authors
Ahn, Jong Hyeon; Kang, Min Chae; Lee, Dongyoung; Cho, Jin Whan; Park, Kyung-Ah; Youn, Jinyoung
- Abstract
Orthostatic hypotension (OH) is a common non-motor symptom in Parkinson's disease (PD). OH can cause cerebral and retinal hypoperfusion and is associated with microvascular damage in PD. Optical coherence tomography angiography (OCTA) is a non-invasive technology that can be used to visualize the retinal microvasculature and detect microvascular damage in PD. In the present study, 51 PD patients (OH , n = 20, 37 eyes; OH−, n = 32, 61 eyes) and 51 healthy controls (100 eyes) were evaluated. The Unified Parkinson's Disease Rating Scale III, Hoehn and Yahr scale, Montreal Cognitive Assessment, levodopa equivalent daily dose, and vascular risk factors, including hypertension, diabetes, and dyslipidemia, were investigated. PD patients underwent a head-up tilt (HUT) test. The PD patients had a lower superficial retinal capillary plexus (SRCP) density in the central region than control patients. The PDOH group had lower vessel density in the SRCP of the central region compared with the control group and lower vessel density in the DRCP of the central region than the PDOH− and control groups. The changes in systolic and diastolic blood pressure during the HUT test in PD patients showed a negative correlation with the vessel density in the DRCP central region. The presence of OH was a critical factor associated with central microvasculature damage in PD. These findings indicate that OCTA can be a useful and non-invasive tool for detecting microvasculature damage in PD patients.
- Subjects
PARKINSON'S disease; ORTHOSTATIC hypotension; DIASTOLIC blood pressure; MONTREAL Cognitive Assessment; SYSTOLIC blood pressure; OPTICAL coherence tomography
- Publication
NPJ Parkinson's Disease, 2023, Vol 9, Issue 1, p1
- ISSN
2373-8057
- Publication type
Academic Journal
- DOI
10.1038/s41531-023-00480-6