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- Title
Concurrent optoacoustic tomography and magnetic resonance imaging of resting-state functional connectivity in the mouse brain.
- Authors
Gezginer, Irmak; Chen, Zhenyue; Yoshihara, Hikari A. I.; Deán-Ben, Xosé Luís; Zerbi, Valerio; Razansky, Daniel
- Abstract
Resting-state functional connectivity (rsFC) has been essential to elucidate the intricacy of brain organization, further revealing clinical biomarkers of neurological disorders. Although functional magnetic resonance imaging (fMRI) remains a cornerstone in the field of rsFC recordings, its interpretation is often hindered by the convoluted physiological origin of the blood-oxygen-level-dependent (BOLD) contrast affected by multiple factors. Here, we capitalize on the unique concurrent multiparametric hemodynamic recordings of a hybrid magnetic resonance optoacoustic tomography platform to comprehensively characterize rsFC in female mice. The unique blood oxygenation readings and high spatio-temporal resolution at depths provided by functional optoacoustic (fOA) imaging offer an effective means for elucidating the connection between BOLD and hemoglobin responses. Seed-based and independent component analyses reveal spatially overlapping bilateral correlations between the fMRI-BOLD readings and the multiple hemodynamic components measured with fOA but also subtle discrepancies, particularly in anti-correlations. Notably, total hemoglobin and oxygenated hemoglobin components are found to exhibit stronger correlation with BOLD than deoxygenated hemoglobin, challenging conventional assumptions on the BOLD signal origin. Simultaneous magnetic resonance optoacoustic readings reveal a high correspondence between BOLD and hemoglobin signals in mouse functional connectivity. Total and oxygenated hemoglobin exhibit stronger correlations with BOLD than deoxygenated hemoglobin.
- Subjects
DEOXYHEMOGLOBIN; FUNCTIONAL magnetic resonance imaging; INDEPENDENT component analysis; FUNCTIONAL connectivity; MAGNETIC resonance
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Academic Journal
- DOI
10.1038/s41467-024-54947-y