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- Title
Sex-dependent association of serum vitamin D with muscle strength in older adults: NHANES 2001–2002.
- Authors
Sponchiado, Isabela M.; Limirio, Larissa S.; de Branco, Flávia M. S.; de Oliveira, Erick P.
- Abstract
Background: Although several studies have suggested a potential positive association between serum vitamin D levels and muscle strength in older adults, it remains unclear whether this relationship is sex-dependent. Aim: To evaluate the association between serum 25 hydroxyvitamin D [25(OH)D] levels and muscle strength in older adults and to assess whether this association is dependent on sex. Methods: This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2002. A total of 1173 individuals aged 50–85 years (630 men and 543 women) were included in the analysis. The peak isokinetic force of the knee extensor was assessed using a kinetic communicator isokinetic dynamometer. Serum 25(OH)D levels were measured using the standardized liquid chromatography-tandem mass spectrometry method. Linear regression analyses were conducted to estimate coefficients and 95% confidence intervals for muscle strength across tertiles of serum vitamin D levels, adjusting for potential confounders. Results: Tertiles of serum vitamin D were positively associated with muscle strength in older men (p-trend = 0.007), whereas no association was observed in older women (p-trend = 0.140) or in the total sample (men and women together; p-trend = 0.139). Conclusion: Serum vitamin D levels were positively associated with muscle strength specifically in older men, whereas no association was observed in older women. These results suggest that the relationship between vitamin D and strength may be sex-dependent.
- Subjects
SKELETAL muscle physiology; CROSS-sectional method; PROTEINS; FOOD consumption; DIETARY patterns; INCOME; BODY mass index; STATISTICAL significance; SEX distribution; HYPERTENSION; SMOKING; AGE distribution; DESCRIPTIVE statistics; MUSCLE strength; SURVEYS; RACE; LIQUID chromatography; MASS spectrometry; MARITAL status; ARTHRITIS; URIC acid; EXERCISE tests; CONFIDENCE intervals; ALCOHOL drinking; DATA analysis software; VITAMIN D; ISOKINETIC exercise; MUSCLE contraction; REGRESSION analysis; EDUCATIONAL attainment; DIABETES; PHYSICAL activity; C-reactive protein; OLD age
- Publication
European Journal of Clinical Nutrition, 2024, Vol 78, Issue 10, p847
- ISSN
0954-3007
- Publication type
Academic Journal
- DOI
10.1038/s41430-024-01472-2