Results
Title

Obesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East Asians.

Authors

Nam, Ga Eun; Cho, Kyung Hwan; Han, Kyungdo; Kim, Chul Min; Han, Byoungduck; Cho, Sung Jung; Jung, Seung Jin; Kwon, Yeongkeun; Kim, Yang Hyun; Kim, Do Hoon; Kim, Seon Mee; Choi, Youn Seon; Roh, Yong Kyun; Park, Yong Gyu

Abstract

<bold>Background: </bold>Limited evidence exists regarding associations between obesity and kidney cancer among Asians. We examined the associations between obesity measures and risk of kidney cancer.<bold>Methods: </bold>We included 23,313,046 adults who underwent health examinations provided by the Korean National Health Insurance Service 2009-2012 and performed multivariable Cox proportional hazards regression analyses.<bold>Results: </bold>During 5.4 years of follow-up, 18,036 cases of kidney cancer were recorded, and cumulative incidence was 0.12%. General and abdominal obesity were associated with 1.32-fold increased risk of kidney cancer compared with groups without either obesity status. Underweight individuals showed decreased adjusted hazard ratio (HR) for kidney cancer (0.76, 95% confidence interval: 0.68-0.85) compared to those with normal body mass index (BMI), while the HRs increased among individuals with BMI 23-24.9 kg/m2 (1.23, 1.18-1.28), 25-29.9 kg/m2 (1.41, 1.36-1.46) and ≥30 kg/m2 (1.77, 1.65-1.90) (P for trend < 0.001). HRs of kidney cancer increased with increasing waist circumference (WC) (P for trend < 0.001). Compared to non-obese condition, the coexistence of general and abdominal obesity increased the HR (1.45, 1.40-1.50).<bold>Conclusions: </bold>This study demonstrated positive associations of BMI and WC with kidney cancer risk. General and abdominal obesity may be risk factors of kidney cancer.

Subjects

OBESITY complications; RELATIVE medical risk; KIDNEY tumors; WAIST circumference; QUESTIONNAIRES; BODY mass index; LONGITUDINAL method; PROPORTIONAL hazards models

Publication

British Journal of Cancer, 2019, Vol 121, Issue 3, p271

ISSN

0007-0920

Publication type

Academic Journal

DOI

10.1038/s41416-019-0500-z