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Molecular mechanisms of HIV integration and therapeutic intervention.
- Published in:
- Expert Reviews in Molecular Medicine, 2007, v. 9, n. 6, p. 1, doi. 10.1017/S1462399407000257
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- Article
Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection.
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- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33662-6
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- Article
Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking.
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- EMBO Journal, 1997, v. 16, n. 22, p. 6849, doi. 10.1093/emboj/16.22.6849
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- Article
Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.
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- eLife, 2020, p. 1, doi. 10.7554/eLife.54311
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- Article
Molecular mechanisms of retroviral integration site selection.
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- Nucleic Acids Research, 2014, v. 42, n. 16, p. 10209, doi. 10.1093/nar/gku769
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- Article
Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding.
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- Nucleic Acids Research, 2014, v. 42, n. 8, p. 5164, doi. 10.1093/nar/gku136
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- Publication type:
- Article
HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.
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- Nucleic Acids Research, 2012, v. 40, n. 22, p. 11518, doi. 10.1093/nar/gks913
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- Article
Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro.
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- Nucleic Acids Research, 2008, v. 36, n. 4, p. 1237
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- Article
Multivalent interactions essential for lentiviral integrase function.
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- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29928-8
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- Publication type:
- Article
Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75.
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- Nature Structural & Molecular Biology, 2005, v. 12, n. 6, p. 526, doi. 10.1038/nsmb937
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- Article
Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice.
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- PLoS ONE, 2015, v. 10, n. 9, p. 1, doi. 10.1371/journal.pone.0137797
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- Article
Engineered Hyperactive Integrase for Concerted HIV-1 DNA Integration.
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- PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0105078
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- Publication type:
- Article
Biochemical Characterization of Novel Retroviral Integrase Proteins.
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- PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0076638
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- Publication type:
- Article
A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site.
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- PLoS Pathogens, 2021, v. 17, n. 7, p. 1, doi. 10.1371/journal.ppat.1009671
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- Article
Close‐up: HIV/SIV intasome structures shed new light on integrase inhibitor binding and viral escape mechanisms.
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- FEBS Journal, 2021, v. 288, n. 2, p. 427, doi. 10.1111/febs.15438
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- Article
Retroviral intasome assembly and inhibition of DNA strand transfer.
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- Nature, 2010, v. 464, n. 7286, p. 232, doi. 10.1038/nature08784
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- Article
Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome.
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- Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-01855-2
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- Publication type:
- Article
A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo.
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- Nucleic Acids Research, 2006, v. 34, n. 5, p. 1653, doi. 10.1093/nar/gkl052
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- Article
Most of the avian genome appears available for retroviral DNA integration.
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- BioEssays, 1994, v. 16, n. 11, p. 797, doi. 10.1002/bies.950161105
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- Article
Cellular and molecular mechanisms of HIV-1 integration targeting.
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- Cellular & Molecular Life Sciences, 2018, v. 75, n. 14, p. 2491, doi. 10.1007/s00018-018-2772-5
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- Article
HIV-1 integrase binding to genomic RNA 5′-UTR induces local structural changes in vitro and in virio.
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- Retrovirology, 2021, v. 18, n. 1, p. 1, doi. 10.1186/s12977-021-00582-0
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- Article
The Lentiviral Integrase Binding Protein LEDGF/p75 and HIV-1 Replication.
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- PLoS Pathogens, 2008, v. 4, n. 3, p. 1, doi. 10.1371/journal.ppat.1000046
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- Article
Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis.
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- PLoS Biology, 2020, v. 18, n. 12, p. 1, doi. 10.1371/journal.pbio.3001015
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- Article
HIV-1 Intasomes Assembled with Excess Integrase C-Terminal Domain Protein Facilitate Structural Studies by Cryo-EM and Reveal the Role of the Integrase C-Terminal Tail in HIV-1 Integration.
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- Viruses (1999-4915), 2024, v. 16, n. 7, p. 1166, doi. 10.3390/v16071166
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- Article
Brief Histories of Retroviral Integration Research and Associated International Conferences.
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- Viruses (1999-4915), 2024, v. 16, n. 4, p. 604, doi. 10.3390/v16040604
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- Publication type:
- Article
Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors.
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- Viruses (1999-4915), 2022, v. 14, n. 9, p. 1883, doi. 10.3390/v14091883
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- Article
Multimodal Functionalities of HIV-1 Integrase.
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- Viruses (1999-4915), 2022, v. 14, n. 5, p. 926, doi. 10.3390/v14050926
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- Article
HIV Capsid and Integration Targeting.
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- Viruses (1999-4915), 2021, v. 13, n. 1, p. 125, doi. 10.3390/v13010125
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- Article
Viral and Cellular Requirements for the Nuclear Entry of Retroviral Preintegration Nucleoprotein Complexes.
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- Viruses (1999-4915), 2013, v. 5, n. 10, p. 2483, doi. 10.3390/v5102483
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- Article
Nucleoporin NUP153 Phenylalanine-Glycine Motifs Engage a Common Binding Pocket within the HIV-1 Capsid Protein to Mediate Lentiviral Infectivity.
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- PLoS Pathogens, 2013, v. 9, n. 10, p. 1, doi. 10.1371/journal.ppat.1003693
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- Article
Structural Basis for Functional Tetramerization of Lentiviral Integrase.
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- PLoS Pathogens, 2009, v. 5, n. 7, p. 1, doi. 10.1371/journal.ppat.1000515
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- Article
The SET Complex Acts as a Barrier to Autointegration of HIV-1.
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- PLoS Pathogens, 2009, v. 5, n. 3, p. 1, doi. 10.1371/journal.ppat.1000327
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- Publication type:
- Article
A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75.
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- PLoS Pathogens, 2009, v. 5, n. 1, p. 1, doi. 10.1371/journal.ppat.1000259
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- Article
Correction: Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.
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- 2016
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- Correction Notice
Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.
- Published in:
- PLoS Pathogens, 2016, v. 12, n. 8, p. 1, doi. 10.1371/journal.ppat.1005860
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- Article
The structural biology of HIV-1: mechanistic and therapeutic insights.
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- Nature Reviews Microbiology, 2012, v. 10, n. 4, p. 279, doi. 10.1038/nrmicro2747
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- Article
Foreign DNA capture during CRISPR-Cas adaptive immunity.
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- Nature, 2015, v. 527, n. 7579, p. 535, doi. 10.1038/nature15760
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- Article
Structural basis for retroviral integration into nucleosomes.
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- Nature, 2015, v. 523, n. 7560, p. 366, doi. 10.1038/nature14495
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- Article
Integrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity.
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- Nature, 2015, v. 519, n. 7542, p. 193, doi. 10.1038/nature14237
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- Publication type:
- Article
Spatial and Genomic Correlates of HIV-1 Integration Site Targeting.
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- Cells (2073-4409), 2022, v. 11, n. 4, p. 655, doi. 10.3390/cells11040655
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- Article
HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration.
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- Nucleic Acids Research, 2024, v. 52, n. 18, p. 11060, doi. 10.1093/nar/gkae769
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- Article
B-to-A transition in target DNA during retroviral integration.
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- Nucleic Acids Research, 2022, v. 50, n. 15, p. 8898, doi. 10.1093/nar/gkac644
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- Article
Genome-wide CRISPR/Cas9 transcriptional activation screen identifies a histone acetyltransferase inhibitor complex as a regulator of HIV-1 integration.
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- Nucleic Acids Research, 2022, v. 50, n. 12, p. 6687, doi. 10.1093/nar/gkac464
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- Publication type:
- Article
rigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration in vitro and in vivo.
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- Nucleic Acids Research, 2021, v. 49, n. 13, p. 7330, doi. 10.1093/nar/gkab514
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- Article
Factors that mold the nuclear landscape of HIV-1 integration.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 621, doi. 10.1093/nar/gkaa1207
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- Article
Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.
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- Nucleic Acids Research, 2019, v. 47, n. 9, p. 4663, doi. 10.1093/nar/gkz206
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- Article
Multiplex single-cell visualization of nucleic acids and protein during HIV infection.
- Published in:
- Nature Communications, 2017, v. 8, n. 12, p. 1, doi. 10.1038/s41467-017-01693-z
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- Article
Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model.
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- PLoS Pathogens, 2019, v. 15, n. 12, p. 1, doi. 10.1371/journal.ppat.1008154
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- Publication type:
- Article
D614G and SARS-CoV-2 replication fitness.
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- Signal Transduction & Targeted Therapy, 2021, v. 6, n. 1, p. 1, doi. 10.1038/s41392-021-00498-3
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- Article
Publisher Correction: HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.
- Published in:
- 2020
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- Publication type:
- Correction Notice