Works matching DE "TUMOR suppressor proteins"

Results: 3271

PTEN is a protein tyrosine phosphatase for IRS1.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 6, p. 522, doi. 10.1038/nsmb.2828

By:

Shi, Yuji;
Wang, Junru;
Chandarlapaty, Sarat;
Cross, Justin;
Thompson, Craig;
Rosen, Neal;
Jiang, Xuejun

Publication type:

Article

PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 9, p. 916, doi. 10.1038/nsmb.2353

By:

Cui, Gaofeng;
Park, Sungman;
Badeaux, Aimee I;
Kim, Donghwa;
Lee, Joseph;
Thompson, James R;
Yan, Fei;
Kaneko, Satoshi;
Yuan, Zengqiang;
Botuyan, Maria Victoria;
Bedford, Mark T;
Cheng, Jin Q;
Mer, Georges

Publication type:

Article

A glutamate switch controls voltage-sensitive phosphatase function.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 6, p. 633, doi. 10.1038/nsmb.2289

By:

Liu, Lijun;
Kohout, Susy C;
Xu, Qiang;
Müller, Simone;
Kimberlin, Christopher R;
Isacoff, Ehud Y;
Minor, Daniel L

Publication type:

Article

Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 10, p. 1086, doi. 10.1038/nsmb.2114

By:

Hagn, Franz;
Lagleder, Stephan;
Retzlaff, Marco;
Rohrberg, Julia;
Demmer, Oliver;
Richter, Klaus;
Buchner, Johannes;
Kessler, Horst

Publication type:

Article

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 12, p. 1461, doi. 10.1038/nsmb.1943

By:

Badie, Sophie;
Escandell, Jose M.;
Bouwman, Peter;
Carlos, Ana Rita;
Thanasoula, Maria;
Gallardo, Maria M.;
Suram, Anitha;
Jaco, Isabel;
Benitez, Javier;
Herbig, Utz;
Blasco, Maria A.;
Jonkers, Jos;
Tarsounas, Madalena

Publication type:

Article

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 10, p. 1263, doi. 10.1038/nsmb.1905

By:

Thorslund, Tina;
McIlwraith, Michael J.;
Compton, Sarah A.;
Lekomtsev, Sergey;
Petronczki, Mark;
Griffith, Jack D.;
West, Stephen C.

Publication type:

Article

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 10, p. 1260, doi. 10.1038/nsmb.1904

By:

Jie Liu;
Doty, Tammy;
Gibson, Bryan;
Heyer, Wolf-Dietrich

Publication type:

Article

An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 9, p. 1051, doi. 10.1038/nsmb.1868

By:

Hirschi, Alexander;
Cecchini, Matthew;
Steinhardt, Rachel C;
Schamber, Michael R;
Dick, Frederick A;
Rubin, Seth M

Publication type:

Article

The C terminus of p53 binds the N-terminal domain of MDM2.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 8, p. 982, doi. 10.1038/nsmb.1872

By:

Poyurovsky, Masha V.;
Katz, Chen;
Laptenko, Oleg;
Beckerman, Rachel;
Lokshin, Maria;
Jinwoo Ahn;
Byeon, In-Ja L.;
Gabizon, Ronen;
Mattia, Melissa;
Zupnick, Andrew;
Brown, Lewis M.;
Friedler, Assaf;
Prives, Carol

Publication type:

Article

Research highlights.

Published in:: Nature Structural & Molecular Biology, 2010, v. 17, n. 6, p. 678, doi. 10.1038/nsmb0610-678
Publication type:: Article

Four p(53)s in a pod.

Published in:

2010

By:

Chitayat, Seth;
Arrowsmith, Cheryl H.

Publication type:

Opinion

Cabin1 restrains p53 activity on chromatin.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 9, p. 910, doi. 10.1038/nsmb.1657

By:

Hyonchol Jang;
Soo-Youn Choi;
Eun-Jung Cho;
Hong-Duk Youn

Publication type:

Article

Molecular basis of Pirh2-mediated p53 ubiquitylation.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 12, p. 1334, doi. 10.1038/nsmb.1521

By:

Sheng, Yi;
Laister, Rob C.;
Lemak, Alexander;
Wu, Bin;
Tai, Elizabeth;
Duan, Shili;
Lukin, Jonathan;
Sunnerhagen, Maria;
Srisailam, Sampath;
Karra, Murthy;
Benchimol, Sam;
Arrowsmith, Cheryl H.

Publication type:

Article

When loose ends finally meet.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 12, p. 1241, doi. 10.1038/nsmb1208-1241

By:

Huen, Michael S. Y.;
Chen, Junjie

Publication type:

Article

Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 3, p. 215, doi. 10.1038/nsmb1208

By:

Xia, Mingxuan;
Land, Hartmut

Publication type:

Article

Research highlights.

Published in:: Nature Structural & Molecular Biology, 2007, v. 14, n. 2, p. 102, doi. 10.1038/nsmb0207-102
Publication type:: Article

The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 9, p. 763, doi. 10.1038/nsmb981

By:

Mosedale, Georgina;
Niedzwiedz, Wojciech;
Alpi, Arno;
Perrina, Franco;
Pereira-Leal, Jose B;
Johnson, Mark;
Langevin, Frederic;
Pace, Paul;
Patel, Ketan J

Publication type:

Article

The tumor suppressor p16<sup>INK4a</sup> prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 8, p. 699, doi. 10.1038/nsmb960

By:

Bu Young Choi;
Hong Seok Choi;
Kwangseok Ko;
Yong-Yeon Cho;
Feng Zhu;
Bong Seok Kang;
Ermakova, Svetlana P.;
Wei-Ya Ma;
Bode, Ann M.;
Zigang Dong

Publication type:

Article

Mediating repair.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 3, p. 213, doi. 10.1038/nsmb0305-213

By:

Sung, Patrick

Publication type:

Article

Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth.

Published in:

PLoS Biology, 2018, v. 16, n. 5, p. 1, doi. 10.1371/journal.pbio.2002912

By:

Ménard, Marie;
Costechareyre, Clélia;
Ichim, Gabriel;
Blachier, Jonathan;
Neves, David;
Jarrosson-Wuilleme, Loraine;
Depping, Reinhard;
Koster, Jan;
Saintigny, Pierre;
Mehlen, Patrick;
Tauszig-Delamasure, Servane

Publication type:

Article

The phosphorylation status of merlin in sporadic vestibular Schwannomas.

Published in:

Molecular & Cellular Biochemistry, 2009, v. 324, n. 1/2, p. 201, doi. 10.1007/s11010-008-0014-0

By:

Zhaoyan Wang;
Yanjun Lu;
Juanjuan Tang;
Haojie Wang;
Hao Wu

Publication type:

Article

Prohibitin suppresses renal interstitial fibroblasts proliferation and phenotypic change induced by transforming growth factor-Î²1.

Published in:

Molecular & Cellular Biochemistry, 2007, v. 295, n. 1, p. 167, doi. 10.1007/s11010-006-9286-4

By:

Wei Guo;
Hong Xu;
Jing Chen;
Yong Yang;
Jia Jin;
Rui Fu;
Hai Liu;
Xi Zha;
Zhi Zhang;
Wen Huang

Publication type:

Article

Molecular dynamics simulation of S100B protein to explore ligand blockage of the interaction with p53 protein.

Published in:

Journal of Computer-Aided Molecular Design, 2009, v. 23, n. 10, p. 705, doi. 10.1007/s10822-009-9294-z

By:

Zhigang Zhou;
Yumin Li

Publication type:

Article

From modulation of cellular plasticity to potentiation of therapeutic resistance: new and emerging roles of MYB transcription factors in human malignancies.

Published in:

Cancer & Metastasis Reviews, 2024, v. 43, n. 1, p. 409, doi. 10.1007/s10555-023-10153-8

By:

Anand, Shashi;
Vikramdeo, Kunwar Somesh;
Sudan, Sarabjeet Kour;
Sharma, Amod;
Acharya, Srijan;
Khan, Mohammad Aslam;
Singh, Seema;
Singh, Ajay Pratap

Publication type:

Article

Caveolin-1 function at the plasma membrane and in intracellular compartments in cancer.

Published in:

Cancer & Metastasis Reviews, 2020, v. 39, n. 2, p. 435, doi. 10.1007/s10555-020-09890-x

By:

Simón, L.;
Campos, A.;
Leyton, L.;
Quest, A. F. G.

Publication type:

Article

KISS1 in breast cancer progression and autophagy.

Published in:

Cancer & Metastasis Reviews, 2019, v. 38, n. 3, p. 493, doi. 10.1007/s10555-019-09814-4

By:

Ulasov, Ilya V.;
Borovjagin, Anton V.;
Timashev, Peter;
Cristofanili, Massimo;
Welch, Danny R.

Publication type:

Article

Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting.

Published in:

Cancer & Metastasis Reviews, 2018, v. 37, n. 1, p. 159, doi. 10.1007/s10555-017-9725-6

By:

Hankey, William;
Frankel, Wendy L.;
Groden, Joanna

Publication type:

Article

E3 ubiquitin ligases in cancer and implications for therapies.

Published in:

Cancer & Metastasis Reviews, 2017, v. 36, n. 4, p. 683, doi. 10.1007/s10555-017-9703-z

By:

Wang, Dong;
Ma, Leina;
Wang, Bin;
Liu, Jia;
Wei, Wenyi

Publication type:

Article

Ubiquitin carboxyl-terminal hydrolases: involvement in cancer progression and clinical implications.

Published in:

Cancer & Metastasis Reviews, 2017, v. 36, n. 4, p. 669, doi. 10.1007/s10555-017-9702-0

By:

Fang, Ying;
Shen, Xizhong

Publication type:

Article

The role of deubiquitinases in breast cancer.

Published in:

Cancer & Metastasis Reviews, 2016, v. 35, n. 4, p. 589, doi. 10.1007/s10555-016-9640-2

By:

Xiao, Zhenna;
Zhang, Peijing;
Ma, Li

Publication type:

Article

p53 expression status is a significant molecular marker in predicting the time to endocrine therapy failure in recurrent breast cancer: a cohort study.

Published in:

International Journal of Clinical Oncology, 2006, v. 11, n. 6, p. 426, doi. 10.1007/s10147-006-0601-6

By:

Kai, Kazuharu;
Nishimura, Reiki;
Arima, Nobuyuki;
Miyayama, Haruhiko;
Iwase, Hirotaka

Publication type:

Article

Recent advances in ideas on the molecular pathology and clinical aspects of Von Hippel-Lindau disease.

Published in:

International Journal of Clinical Oncology, 2004, v. 9, n. 4, p. 283, doi. 10.1007/s10147-004-0415-3

By:

Shuin, Taro;
Yamazaki, Ichiro;
Tamura, Kenji;
Kamada, Masayuki;
Ashida, Shingo

Publication type:

Article

PTEN expression in endometrial hyperplasia and risk of cancer: a systematic review and meta-analysis.

Published in:

2019

By:

Raffone, Antonio;
Travaglino, Antonio;
Saccone, Gabriele;
Viggiani, Martina;
Giampaolino, Pierluigi;
Insabato, Luigi;
Mollo, Antonio;
De Placido, Giuseppe;
Zullo, Fulvio

Publication type:

journal article

Expression and methylation status of the Syk gene in cervical carcinoma.

Published in:

2011

By:

Zhao, Shuping;
Sun, Guixia;
Tony, Parks;
Ma, Dehua;
Zhao, Chengquan;
Tony, Parks W

Publication type:

journal article

Role of cdk4, p16, and Rb Expression in the Prognosis of Bronchioloalveolar Carcinomas.

Published in:

Respiration, 2005, v. 72, n. 1, p. 68, doi. 10.1159/000083403

By:

M. Ghazizadeh;
E. Jin;
H. Shimizu;
M. Fujiwara;
S. Arai;
Y. Ohaki;
T. Takemura;
O. Kawanami

Publication type:

Article

Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment.

Published in:

Nature, 2015, v. 523, n. 7560, p. 352, doi. 10.1038/nature14430

By:

Alexandrova, E. M.;
Yallowitz, A. R.;
Li, D.;
Xu, S.;
Schulz, R.;
Proia, D. A.;
Lozano, G.;
Dobbelstein, M.;
Moll, U. M.

Publication type:

Article

Cancer: Precise control of localized signals.

Published in:

Nature, 2015, v. 522, n. 7554, p. 38, doi. 10.1038/nature14531

By:

Stambolic, Vuk

Publication type:

Article

IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo.

Published in:

Nature, 2015, v. 517, n. 7536, p. 626, doi. 10.1038/nature13910

By:

Venkatanarayan, Avinashnarayan;
Raulji, Payal;
Norton, William;
Chakravarti, Deepavali;
Coarfa, Cristian;
Su, Xiaohua;
Sandur, Santosh K.;
Ramirez, Marc S.;
Lee, Jaehuk;
Kingsley, Charles V.;
Sananikone, Eliot F.;
Rajapakshe, Kimal;
Naff, Katherine;
Parker-Thornburg, Jan;
Bankson, James A.;
Tsai, Kenneth Y.;
Gunaratne, Preethi H.;
Flores, Elsa R.

Publication type:

Article

Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway.

Published in:

Nature, 2014, v. 514, n. 7521, p. 252, doi. 10.1038/nature13553

By:

Faehnle, Christopher R.;
Walleshauser, Jack;
Joshua-Tor, Leemor

Publication type:

Article

Fructose-1,6-bisphosphatase opposes renal carcinoma progression.

Published in:

Nature, 2014, v. 513, n. 7517, p. 251, doi. 10.1038/nature13557

By:

Li, Bo;
Qiu, Bo;
Ochocki, Joshua D.;
Lee, David S. M.;
Mathew, Lijoy K.;
Walton, Zandra E.;
Keith, Brian;
Mancuso, Anthony;
Gade, Terence P. F.;
Nissim, Itzhak;
Simon, M. Celeste

Publication type:

Article

Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins.

Published in:

Nature, 2014, v. 513, n. 7517, p. 256, doi. 10.1038/nature13466

By:

Goodarzi, Hani;
Zhang, Steven;
Buss, Colin G.;
Fish, Lisa;
Tavazoie, Sohail F.;
Tavazoie, Saeed

Publication type:

Article

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.

Published in:

Nature, 2014, v. 508, n. 7495, p. 222, doi. 10.1038/nature13194

By:

Huber, Kilian V. M.;
Salah, Eidarus;
Radic, Branka;
Gridling, Manuela;
Elkins, Jonathan M.;
Stukalov, Alexey;
Jemth, Ann-Sofie;
Göktürk, Camilla;
Sanjiv, Kumar;
Strömberg, Kia;
Pham, Therese;
Berglund, Ulrika Warpman;
Colinge, Jacques;
Bennett, Keiryn L.;
Loizou, Joanna I.;
Helleday, Thomas;
Knapp, Stefan;
Superti-Furga, Giulio

Publication type:

Article

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.

Published in:

Nature, 2014, v. 508, n. 7495, p. 215, doi. 10.1038/nature13181

By:

Gad, Helge;
Koolmeister, Tobias;
Jemth, Ann-Sofie;
Eshtad, Saeed;
Jacques, Sylvain A.;
Ström, Cecilia E.;
Svensson, Linda M.;
Schultz, Niklas;
Lundbäck, Thomas;
Einarsdottir, Berglind Osk;
Saleh, Aljona;
Göktürk, Camilla;
Baranczewski, Pawel;
Svensson, Richard;
Berntsson, Ronnie P.-A.;
Gustafsson, Robert;
Strömberg, Kia;
Sanjiv, Kumar;
Jacques-Cordonnier, Marie-Caroline;
Desroses, Matthieu

Publication type:

Article

ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression.

Published in:

Nature, 2014, v. 508, n. 7495, p. 263, doi. 10.1038/nature13045

By:

Wen, Hong;
Li, Yuanyuan;
Xi, Yuanxin;
Jiang, Shiming;
Stratton, Sabrina;
Peng, Danni;
Tanaka, Kaori;
Ren, Yongfeng;
Xia, Zheng;
Wu, Jun;
Li, Bing;
Barton, Michelle C.;
Li, Wei;
Li, Haitao;
Shi, Xiaobing

Publication type:

Article

Cancer: Switching p53 back on.

Published in:: Nature, 2012, v. 485, n. 7400, p. 550, doi. 10.1038/485550b
Publication type:: Article

Modulation of immune responses by the tumor suppressor p53.

Published in:

BioDiscovery, 2017, p. 1, doi. 10.7750/BioDiscovery.2013.8.2

By:

Lowe, Julie;
Shatz, Maria;
Resnick, Michael A.;
Menendez, Daniel

Publication type:

Article

Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability in mice.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-07312-0

By:

Gioulbasani, Marianthi;
Äijö, Tarmo;
Liu, Siyao;
Montgomery, Stephanie A.;
Montgomery, Nathan D.;
Corcoran, David;
Tsagaratou, Ageliki

Publication type:

Article

Erratum: TET1 is a tumor suppressor of hematopoietic malignancy.

Published in:

Nature Immunology, 2015, v. 16, n. 8, p. 889, doi. 10.1038/ni0815-889a

By:

Cimmino, Luisa;
Dawlaty, Meelad M;
Ndiaye-Lobry, Delphine;
Yap, Yoon Sing;
Bakogianni, Sofia;
Yu, Yiting;
Bhattacharyya, Sanchari;
Shaknovich, Rita;
Geng, Huimin;
Lobry, Camille;
Mullenders, Jasper;
King, Bryan;
Trimarchi, Thomas;
Aranda-Orgilles, Beatriz;
Liu, Cynthia;
Shen, Steven;
Verma, Amit K;
Jaenisch, Rudolf;
Aifantis, Iannis

Publication type:

Article

Corrigendum: The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation.

Published in:

Nature Immunology, 2015, v. 16, n. 7, p. 785, doi. 10.1038/ni0715-785b

By:

Zhang, Qiao;
Kuang, Hong;
Chen, Cong;
Yan, Jie;
Do-Umehara, Hanh Chi;
Liu, Xin-yuan;
Dada, Laura;
Ridge, Karen M;
Chandel, Navdeep S;
Liu, Jing

Publication type:

Article

A 'Tsc, Tsc' keeps the kids quie(scen)t and holds down ROS.

Published in:

Nature Immunology, 2011, v. 12, n. 9, p. 811, doi. 10.1038/ni.2092

By:

Boothby, Mark;
Lee, Keunwook

Publication type:

Article