Title: Viral pathogenesis: Vpu puts the brakes on ADCC.
Authors: Kåhrström, Christina Tobin
Abstract: The article explores on the genetic mutation of the human immunodeficiency virus (HIV)-1 viral protein U (Vpu) that lead to the increase of antibody-dependent cell-mediated cytotoxicity (ADCC). It states that type I interferon (IFN) help prevent the release and the spread of viruses through tethering to the cell surface. It also notes that infected cells with Vpu mutation A14L has the higher level of antibody binding than infected cells with wild-type virus.
Subjects: HIV; VIRAL proteins; ANTIBODY-dependent cell cytotoxicity; INTERFERON inducers; IMMUNITY
Publication: Nature Reviews Microbiology, 2014, Vol 12, Issue 6, p397
ISSN: 1740-1526
Publication type: Academic Journal
DOI: 10.1038/nrmicro3282

Viral pathogenesis: Vpu puts the brakes on ADCC.

Kåhrström, Christina Tobin