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- Title
Viral pathogenesis: Vpu puts the brakes on ADCC.
- Authors
Kåhrström, Christina Tobin
- Abstract
The article explores on the genetic mutation of the human immunodeficiency virus (HIV)-1 viral protein U (Vpu) that lead to the increase of antibody-dependent cell-mediated cytotoxicity (ADCC). It states that type I interferon (IFN) help prevent the release and the spread of viruses through tethering to the cell surface. It also notes that infected cells with Vpu mutation A14L has the higher level of antibody binding than infected cells with wild-type virus.
- Subjects
HIV; VIRAL proteins; ANTIBODY-dependent cell cytotoxicity; INTERFERON inducers; IMMUNITY
- Publication
Nature Reviews Microbiology, 2014, Vol 12, Issue 6, p397
- ISSN
1740-1526
- Publication type
Academic Journal
- DOI
10.1038/nrmicro3282