The article cites a research study by B.F.C. Kafsack and colleagues, published March 10, 2014 in the online edition of the journal "Nature Reviews Microbiology," which identifies transcription factor AP2-G as a master regulator of gametocytogenesis. The life cycle of Plasmodium spp. involves several distinct developmental stages. Kafsack and colleagues found that transcript levels and gametocyte formation were positively linked in Plasmodium falciparum.