Title: Playing fast and loose with mutation.
Authors: Mather, Alison E.; Harris, Simon R.
Abstract: The article investigates the involvement of hypermutation on chronic bacterial infection and its phylogenomic analyses implication. It cites studies which showed that hypermutator isolates increased numbers of single nucleotide polymorphisms (SNPs) and is associated with bacterial resistance as well as nonsynonymous mutations in mismatch repair (MMR)-related. It also mentions the analytical problems in hypermutation and the bias results in the inclusion of hypermutating strains.
Subjects: BACTERIAL diseases; DRUG resistance in bacteria; SINGLE nucleotide polymorphisms; MICROBIAL mutation; MATHEMATICAL analysis
Publication: Nature Reviews Microbiology, 2013, Vol 11, Issue 12, p822
ISSN: 1740-1526
Publication type: Academic Journal
DOI: 10.1038/nrmicro3164

Playing fast and loose with mutation.

Mather, Alison E.; Harris, Simon R.