We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Playing fast and loose with mutation.
- Authors
Mather, Alison E.; Harris, Simon R.
- Abstract
The article investigates the involvement of hypermutation on chronic bacterial infection and its phylogenomic analyses implication. It cites studies which showed that hypermutator isolates increased numbers of single nucleotide polymorphisms (SNPs) and is associated with bacterial resistance as well as nonsynonymous mutations in mismatch repair (MMR)-related. It also mentions the analytical problems in hypermutation and the bias results in the inclusion of hypermutating strains.
- Subjects
BACTERIAL diseases; DRUG resistance in bacteria; SINGLE nucleotide polymorphisms; MICROBIAL mutation; MATHEMATICAL analysis
- Publication
Nature Reviews Microbiology, 2013, Vol 11, Issue 12, p822
- ISSN
1740-1526
- Publication type
Academic Journal
- DOI
10.1038/nrmicro3164