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- Title
Antimicrobials: Silencing bacterial communication.
- Authors
Kåhrström, Christina Tobin
- Abstract
The article discusses the study conducted by C. T. O'Loughlin and colleagues which describes the use of a synthetic compound meta-bromo-thiolactone (mBTL) for inhibition of the quorum-sensing receptors LasR and RhlR of the bacteria Pseudomonas aeruginosa. The authors of the study observed that mBTL is a potent inhibitor of both the production of the virulence factor pyocyanin and biofilm formation. They conclude that mBTL attenuates virulence and has potential as an antimicrobial drug.
- Subjects
QUORUM sensing; PSEUDOMONAS aeruginosa; VIRULENCE of bacteria; ANTI-infective agents; MICROBIAL virulence
- Publication
Nature Reviews Microbiology, 2013, Vol 11, Issue 12, p820
- ISSN
1740-1526
- Publication type
Academic Journal
- DOI
10.1038/nrmicro3163