Title: Antimicrobials: Silencing bacterial communication.
Authors: Kåhrström, Christina Tobin
Abstract: The article discusses the study conducted by C. T. O'Loughlin and colleagues which describes the use of a synthetic compound meta-bromo-thiolactone (mBTL) for inhibition of the quorum-sensing receptors LasR and RhlR of the bacteria Pseudomonas aeruginosa. The authors of the study observed that mBTL is a potent inhibitor of both the production of the virulence factor pyocyanin and biofilm formation. They conclude that mBTL attenuates virulence and has potential as an antimicrobial drug.
Subjects: QUORUM sensing; PSEUDOMONAS aeruginosa; VIRULENCE of bacteria; ANTI-infective agents; MICROBIAL virulence
Publication: Nature Reviews Microbiology, 2013, Vol 11, Issue 12, p820
ISSN: 1740-1526
Publication type: Academic Journal
DOI: 10.1038/nrmicro3163

Antimicrobials: Silencing bacterial communication.

Kåhrström, Christina Tobin