Title: Bacterial pathogenesis: CXCRs mark the spot.
Authors: Hofer, Ursula
Abstract: The article reports on the results of a study which explain LukED-mediated killing of neutrophils. The study revealed that leukotoxin ED (LukED) targets CXC-chemokine receptor 1 (CXCR1) and CXCR2 and efficiently kills neutrophils, which are the most important cell type for Staphylococcus aureus infection control. The study found that DR4- nor DR5- mutated LukE combined with LukD could kill neutrophils while killing of CCR5-positive cells was abolished by DR5-mutated LukE.
Subjects: LEUKOTOXINS; CHEMOKINE receptors; NEUTROPHILS; STAPHYLOCOCCUS aureus infections; CELL-mediated cytotoxicity
Publication: Nature Reviews Microbiology, 2013, Vol 11, Issue 12, p819
ISSN: 1740-1526
Publication type: Academic Journal
DOI: 10.1038/nrmicro3162

Bacterial pathogenesis: CXCRs mark the spot.

Hofer, Ursula