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- Title
Bacterial pathogenesis: CXCRs mark the spot.
- Authors
Hofer, Ursula
- Abstract
The article reports on the results of a study which explain LukED-mediated killing of neutrophils. The study revealed that leukotoxin ED (LukED) targets CXC-chemokine receptor 1 (CXCR1) and CXCR2 and efficiently kills neutrophils, which are the most important cell type for Staphylococcus aureus infection control. The study found that DR4- nor DR5- mutated LukE combined with LukD could kill neutrophils while killing of CCR5-positive cells was abolished by DR5-mutated LukE.
- Subjects
LEUKOTOXINS; CHEMOKINE receptors; NEUTROPHILS; STAPHYLOCOCCUS aureus infections; CELL-mediated cytotoxicity
- Publication
Nature Reviews Microbiology, 2013, Vol 11, Issue 12, p819
- ISSN
1740-1526
- Publication type
Academic Journal
- DOI
10.1038/nrmicro3162