Title: Keeping it quiet: chromatin control of gammaherpesvirus latency.
Authors: Lieberman, Paul M.
Abstract: The human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) establish long-term latent infections associated with diverse human cancers. Viral oncogenesis depends on the ability of the latent viral genome to persist in host nuclei as episomes that express a restricted yet dynamic pattern of viral genes. Multiple epigenetic events control viral episome generation and maintenance. This Review highlights some of the recent findings on the role of chromatin assembly, histone and DNA modifications, and higher-order chromosome structures that enable gammaherpesviruses to establish stable latent infections that mediate viral pathogenesis.
Subjects: CHROMATIN; EPSTEIN-Barr virus; KAPOSI'S sarcoma-associated herpesvirus; CANCER; GENE expression
Publication: Nature Reviews Microbiology, 2013, Vol 11, Issue 12, p863
ISSN: 1740-1526
Publication type: Academic Journal
DOI: 10.1038/nrmicro3135

Keeping it quiet: chromatin control of gammaherpesvirus latency.

Lieberman, Paul M.