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Title

The ins and outs of hepatitis C virus entry and assembly.

Authors

Lindenbach, Brett D.; Rice, Charles M.

Abstract

Hepatitis C virus, a major human pathogen, produces infectious virus particles with several unique features, such as an ability to interact with serum lipoproteins, a dizzyingly complicated process of virus entry, and a pathway of virus assembly and release that is closely linked to lipoprotein secretion. Here, we review these unique features, with an emphasis on recent discoveries concerning virus particle structure, virus entry and virus particle assembly and release.

Subjects

BLOOD lipoproteins; LIVER diseases; HEPATITIS C transmission; LIVER cancer; CANCER risk factors

Publication

Nature Reviews Microbiology, 2013, Vol 11, Issue 10, p688

ISSN

1740-1526

Publication type

Academic Journal

DOI

10.1038/nrmicro3098

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