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- Title
Revenge of the phages: defeating bacterial defences.
- Authors
Samson, Julie E.; Magadán, Alfonso H.; Sabri, Mourad; Moineau, Sylvain
- Abstract
Bacteria and their viral predators (bacteriophages) are locked in a constant battle. In order to proliferate in phage-rich environments, bacteria have an impressive arsenal of defence mechanisms, and in response, phages have evolved counter-strategies to evade these antiviral systems. In this Review, we describe the various tactics that are used by phages to overcome bacterial resistance mechanisms, including adsorption inhibition, restriction-modification, CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins) systems and abortive infection. Furthermore, we consider how these observations have enhanced our knowledge of phage biology, evolution and phage-host interactions.
- Subjects
BACTERIOPHAGES; ANIMAL defenses; HOSTS (Biology); SYMBIOSIS; ANTIVIRAL agents
- Publication
Nature Reviews Microbiology, 2013, Vol 11, Issue 10, p675
- ISSN
1740-1526
- Publication type
Academic Journal
- DOI
10.1038/nrmicro3096