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- Title
Structure, function and biosynthesis of O<sub>2</sub>-tolerant hydrogenases.
- Authors
Fritsch, Johannes; Lenz, Oliver; Friedrich, Bärbel
- Abstract
Molecular hydrogen (H2) is used as an energy source or a way to deposit excess reducing power by a wide range of microorganisms. Both H2 oxidation and production are catalysed by hydrogenases. As these metalloenzymes are usually exquisitely O2 sensitive, H2 metabolism under aerobic conditions, which is known as O2-tolerant H2 cycling, involves hydrogenases that have undergone structural and catalytic adaptations and requires a dedicated biosynthetic machinery. Here, we discuss recent high-resolution crystal structure analyses of a particular subtype of [NiFe]-hydrogenase that is predominantly found in aerobic or facultative aerobic H2-oxidizing bacteria. These data have provided insights into the underlying molecular strategies that allow sustained biological conversion of H2 in the presence of O2.
- Subjects
BIOSYNTHESIS; HYDROGENASE; MICROBIAL biotechnology; CATALYSTS; METALLOENZYMES; MICROORGANISMS; OXIDATION; BEHAVIOR; PHYSIOLOGY
- Publication
Nature Reviews Microbiology, 2013, Vol 11, Issue 2, p106
- ISSN
1740-1526
- Publication type
Academic Journal
- DOI
10.1038/nrmicro2940