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- Title
Host response: Salmonella triumphs over autophagy.
- Authors
Kåhrström, Christina Tobin
- Abstract
The article presents a study which identifies the pathogen-induced amino acid starvation response that activates the autophagic degradation of intracellular bacteria called xenophagy. The researchers have discovered the important host defense pathway and triggers responsible for the induction of xenophagy. The study indicates that intracellular bacteria could perturb other cellular processes regulated by cytosolic amino acid concentrations.
- Subjects
AMINO acids; PATHOGENIC microorganisms; AUTOPHAGY; GROWTH factors; INTRACELLULAR pathogens
- Publication
Nature Reviews Microbiology, 2012, Vol 10, Issue 8, p519
- ISSN
1740-1526
- Publication type
Academic Journal
- DOI
10.1038/nrmicro2835