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- Title
In situ to in silico and back: elucidating the physiology and ecology of Geobacter spp. using genome-scale modelling.
- Authors
Mahadevan, Radhakrishnan; Palsson, Bernhard Ø.; Lovley, Derek R.
- Abstract
There is a wide diversity of unexplored metabolism encoded in the genomes of microorganisms that have an important environmental role. Genome-scale metabolic modelling enables the individual reactions that are encoded in annotated genomes to be organized into a coherent whole, which can then be used to predict metabolic fluxes that will optimize cell function under a range of conditions. In this Review, we summarize a series of studies in which genome-scale metabolic modelling of Geobacter spp. has resulted in an in-depth understanding of their central metabolism and ecology. A similar iterative modelling and experimental approach could accelerate elucidation of the physiology and ecology of other microorganisms inhabiting a diversity of environments, and could guide optimization of the practical applications of these species.
- Subjects
BACTERIAL physiology; BACTERIAL metabolism; MICROBIAL ecology; CELL culture; MOTILITY of bacteria; OXIDATION
- Publication
Nature Reviews Microbiology, 2011, Vol 9, Issue 1, p39
- ISSN
1740-1526
- Publication type
Academic Journal
- DOI
10.1038/nrmicro2456