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- Title
Antiviral immunity: TRIMming the response.
- Authors
Leavy, Olive
- Abstract
The article highlights a study which describes a mechanism by which influenza A virus nonstructural protein 1 (NS1) inhibits the production of type I interferons (IFNs) and antiviral immunity. It indicates that NS1 inhibits the ubiquitylation of viral sensor retinoic acid-inducible gene I (RIG-I) by the ubiquitin ligase tripartite motif-containing 25 (TRIM25) with its downstream signalling partner. The results indicate the important role of NS1-mediated inhibition of the host type I IFN response.
- Subjects
INFLUENZA A virus; INTERFERONS; UBIQUITIN; TRETINOIN; IMMUNITY; MICROBIOLOGY
- Publication
Nature Reviews Microbiology, 2009, Vol 7, Issue 7, p480
- ISSN
1740-1526
- Publication type
Academic Journal
- DOI
10.1038/nrmicro2170