Title: Antiviral immunity: TRIMming the response.
Authors: Leavy, Olive
Abstract: The article highlights a study which describes a mechanism by which influenza A virus nonstructural protein 1 (NS1) inhibits the production of type I interferons (IFNs) and antiviral immunity. It indicates that NS1 inhibits the ubiquitylation of viral sensor retinoic acid-inducible gene I (RIG-I) by the ubiquitin ligase tripartite motif-containing 25 (TRIM25) with its downstream signalling partner. The results indicate the important role of NS1-mediated inhibition of the host type I IFN response.
Subjects: INFLUENZA A virus; INTERFERONS; UBIQUITIN; TRETINOIN; IMMUNITY; MICROBIOLOGY
Publication: Nature Reviews Microbiology, 2009, Vol 7, Issue 7, p480
ISSN: 1740-1526
Publication type: Academic Journal
DOI: 10.1038/nrmicro2170

Antiviral immunity: TRIMming the response.

Leavy, Olive