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Title

Do symbiotic bacteria subvert host immunity?

Authors

Hooper, Lora V.

Abstract

The mammalian intestine is home to dense and complex indigenous bacterial communities. Most of these bacteria establish beneficial symbiotic relationships with their hosts, making important contributions to host metabolism and digestive efficiency. The vast numbers of intestinal bacteria and their proximity to host tissues raise the question of how symbiotic host–bacterial relationships are established without eliciting potentially harmful immune responses. In light of the varied ways in which pathogenic bacteria manipulate host immunity, this Opinion article explores the role of immune suppression, subversion and evasion in the establishment of symbiotic host–bacterial associations.

Subjects

HOST-bacteria relationships; SYMBIOSIS; IMMUNITY; IMMUNOSUPPRESSION; INTESTINAL parasites

Publication

Nature Reviews Microbiology, 2009, Vol 7, Issue 5, p367

ISSN

1740-1526

Publication type

Academic Journal

DOI

10.1038/nrmicro2114

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