Title: Innate immunity: Unfolding antiviral defences.
Authors: Jermy, Andrew
Abstract: The article focuses on the study which revealed that viral infection-triggered unfolded protein response (UPR) leads in the ubiquitination and degradation of IFNAR1. It references a study by J. Liu et al published in the 2009 issue of "Cell Host & Microbe." Over-expression or treatment of UPR inducers promotes the ubiquitination and degradation of IFNAR1. It notes that some viruses exploit the downregulation of the receptor leading to the inhibition of IFN signaling and anti-viral resistance.
Subjects: IMMUNITY; NATURAL immunity; IMMUNOLOGY; VIRUS diseases; VIRAL receptors; ANTIVIRAL agents; INTERFERONS
Publication: Nature Reviews Microbiology, 2009, Vol 7, Issue 3, p177
ISSN: 1740-1526
Publication type: Academic Journal
DOI: 10.1038/nrmicro2098

Innate immunity: Unfolding antiviral defences.

Jermy, Andrew