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- Title
Innate immunity: Unfolding antiviral defences.
- Authors
Jermy, Andrew
- Abstract
The article focuses on the study which revealed that viral infection-triggered unfolded protein response (UPR) leads in the ubiquitination and degradation of IFNAR1. It references a study by J. Liu et al published in the 2009 issue of "Cell Host & Microbe." Over-expression or treatment of UPR inducers promotes the ubiquitination and degradation of IFNAR1. It notes that some viruses exploit the downregulation of the receptor leading to the inhibition of IFN signaling and anti-viral resistance.
- Subjects
IMMUNITY; NATURAL immunity; IMMUNOLOGY; VIRUS diseases; VIRAL receptors; ANTIVIRAL agents; INTERFERONS
- Publication
Nature Reviews Microbiology, 2009, Vol 7, Issue 3, p177
- ISSN
1740-1526
- Publication type
Academic Journal
- DOI
10.1038/nrmicro2098