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- Title
Innate Immunity: Getting in TRIM to fight retroviruses.
- Authors
Surridge, Christopher
- Abstract
The article discusses the TRIMa, part of the tripartite motif (TRIM) protein family needed for natural immunity of retroviruses. Accordingly, TRIM family holds RING domains, B-box domains and coiled-coil region which are necessary to identify and fight viruses. The study of Kar and Langelier with colleagues uses TRIM5a of rhesus monkey with RING domain switch to TRIM21 related human protein. The combat of TRIM5a by tearing capsids and role of oligomerization in the process is to be clarified.
- Subjects
UBIQUITIN; RETROVIRUSES; IMMUNITY; RECOMBINANT proteins; LIGASES
- Publication
Nature Reviews Microbiology, 2008, Vol 6, Issue 11, p797
- ISSN
1740-1526
- Publication type
Academic Journal
- DOI
10.1038/nrmicro2017