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- Title
Antimicrobials: Z-ring Achilles' heel for MRSA.
- Authors
van Ooij, Christiaan
- Abstract
The article reports on the study on PCI90723 compound to defeat meticillin resistant Staphylococcus aureus (MRSA) through aiming at cell division protein FtsZ by Haydon and colleagues. Accordingly, PCI90723 is distinguish by screening more than 500 derivatives of 3-methoxybenzamide, an inhibitor of FtsZ. Moreover, sequence analysis shows bacteria unaffected by PC190723 replace valine 307 of FtsZ with big histidine or arginine residue. PC190723 also suppress cell division of S. aureus.
- Subjects
STAPHYLOCOCCUS aureus; CELL division; ARGININE; ANTIBIOTICS; BACILLUS subtilis
- Publication
Nature Reviews Microbiology, 2008, Vol 6, Issue 11, p799
- ISSN
1740-1526
- Publication type
Academic Journal
- DOI
10.1038/nrmicro2016