Title: Viral pathogenesis: Virus SETs host transcription to off.
Authors: Jermy, Andrew
Abstract: The article discusses the Paramecium bursaria Chlorella virus 1 (PBCV1) that causes the host transcription to off. It presents the study conducted by Zhou and his colleagues, which proposes that the factors that underlie this mechanism are packaged in the PBCV1 virion. VSET was discovered through immunoprecipitation and mass spectrometry. It reveals that expression of vSET was sufficient to repress gene transcription, which confirmed that vSET methylates H3K27 within a living organism.
Subjects: VIRUS research; VIRUS identification; HOST-virus relationships; GENETIC transcription; MASS spectrometry
Publication: Nature Reviews Microbiology, 2008, Vol 6, Issue 10, p713
ISSN: 1740-1526
Publication type: Academic Journal
DOI: 10.1038/nrmicro1993

Viral pathogenesis: Virus SETs host transcription to off.

Jermy, Andrew