Title: Viral pathogenesis: MicroRNA rides tandem.
Authors: Jermy, Andrew
Abstract: The article provides information on a study by P. Sarnow and colleagues on the interaction of a liver-specific miRNA (miR-122) with a target sequence on the 5' noncoding region (NCR) of the hepatitis C virus (HCV) RNA genome and promote viral replication. The region of the HCV RNA was inserted with miR-122 binding site into either the 5' or the 3' NCR of a luciferace reporter in liver cells to address the importance of the 5' position for the miR-122 binding site for stimulating replication.
Subjects: VIRAL replication; HEPATITIS C virus; GENOMICS; SARNOW, P.
Publication: Nature Reviews Microbiology, 2008, Vol 6, Issue 9, p648
ISSN: 1740-1526
Publication type: Academic Journal
DOI: 10.1038/nrmicro1977

Viral pathogenesis: MicroRNA rides tandem.

Jermy, Andrew