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- Title
Architects of assembly: roles of Flaviviridae non-structural proteins in virion morphogenesis.
- Authors
Murray, Catherine L.; Jones, Christopher T.; Rice, Charles M.
- Abstract
Viruses of the Flaviviridae family, including hepatitis C, dengue and bovine viral diarrhoea, are responsible for considerable morbidity and mortality worldwide. Recent advances in our understanding of virion assembly have uncovered commonalities among distantly related members of this family. We discuss the emerging hypothesis that physical virion components are not alone in forming the infectious particle, but that non-structural proteins are intimately involved in orchestrating morphogenesis. Pinpointing the roles of Flaviviridae proteins in virion production could reveal new avenues for antiviral therapeutics.
- Subjects
FLAVIVIRUSES; MORPHOGENESIS; MORTALITY; ETIOLOGY of diseases; ANTIVIRAL agents
- Publication
Nature Reviews Microbiology, 2008, Vol 6, Issue 9, p699
- ISSN
1740-1526
- Publication type
Academic Journal
- DOI
10.1038/nrmicro1928