Results
Title

Architects of assembly: roles of Flaviviridae non-structural proteins in virion morphogenesis.

Authors

Murray, Catherine L.; Jones, Christopher T.; Rice, Charles M.

Abstract

Viruses of the Flaviviridae family, including hepatitis C, dengue and bovine viral diarrhoea, are responsible for considerable morbidity and mortality worldwide. Recent advances in our understanding of virion assembly have uncovered commonalities among distantly related members of this family. We discuss the emerging hypothesis that physical virion components are not alone in forming the infectious particle, but that non-structural proteins are intimately involved in orchestrating morphogenesis. Pinpointing the roles of Flaviviridae proteins in virion production could reveal new avenues for antiviral therapeutics.

Subjects

FLAVIVIRUSES; MORPHOGENESIS; MORTALITY; ETIOLOGY of diseases; ANTIVIRAL agents

Publication

Nature Reviews Microbiology, 2008, Vol 6, Issue 9, p699

ISSN

1740-1526

Publication type

Academic Journal

DOI

10.1038/nrmicro1928