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- Title
Pathogenic epitopes, heterologous immunity and vaccine design.
- Authors
Welsh, Raymond M.; Fujinami, Robert S.
- Abstract
Substantial research has been directed towards the development of a new generation of vaccines that are based on the inclusion of immunogenic epitopes in recombinant vectors. Here we examine the evidence that under certain conditions immunogenic epitopes can do more harm than good and might therefore be considered pathogenic. We suggest that the specific removal of such pathogenic epitopes from vaccines might increase their prophylactic potential, while minimizing the risk of side-effects from vaccine use.
- Subjects
VACCINES; BIOLOGICALS; IMMUNITY; PREVENTIVE medicine; IMMUNOLOGY
- Publication
Nature Reviews Microbiology, 2007, Vol 5, Issue 7, p555
- ISSN
1740-1526
- Publication type
Academic Journal
- DOI
10.1038/nrmicro1709