Title: An epigenetic effector.
Authors: Molloy, Sheilagh
Abstract: The article presents the study on epigenetic effector used by bacterial pathogens to interfere with host signalling pathways. An overview of the study by Arbibe and colleagues of Shigella flexneri that inhibits the transcription of nuclear factor (NF)-KB-regulated genes by preventing histone H3 phosphorylation, the interaction of S. flexneri with the host cell mitogen-activated protein kinase (MAPK) signalling pathways, and the characteristics S. flexneri OspF type III effector, is presented.
Subjects: SHIGELLA flexneri; PATHOGENIC bacteria; EFFERENT pathways; PHOSPHORYLATION; MITOGEN-activated protein kinases; HISTONES
Publication: Nature Reviews Microbiology, 2007, Vol 5, Issue 2, p87
ISSN: 1740-1526
Publication type: Academic Journal
DOI: 10.1038/nrmicro1606

An epigenetic effector.

Molloy, Sheilagh