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- Title
An epigenetic effector.
- Authors
Molloy, Sheilagh
- Abstract
The article presents the study on epigenetic effector used by bacterial pathogens to interfere with host signalling pathways. An overview of the study by Arbibe and colleagues of Shigella flexneri that inhibits the transcription of nuclear factor (NF)-KB-regulated genes by preventing histone H3 phosphorylation, the interaction of S. flexneri with the host cell mitogen-activated protein kinase (MAPK) signalling pathways, and the characteristics S. flexneri OspF type III effector, is presented.
- Subjects
SHIGELLA flexneri; PATHOGENIC bacteria; EFFERENT pathways; PHOSPHORYLATION; MITOGEN-activated protein kinases; HISTONES
- Publication
Nature Reviews Microbiology, 2007, Vol 5, Issue 2, p87
- ISSN
1740-1526
- Publication type
Academic Journal
- DOI
10.1038/nrmicro1606