Results
Title

Structural and mechanistic insights into hepatitis C viral translation initiation.

Authors

Fraser, Christopher S.; Doudna, Jennifer A.

Abstract

Hepatitis C virus uses an internal ribosome entry site (IRES) to control viral protein synthesis by directly recruiting ribosomes to the translation-start site in the viral mRNA. Structural insights coupled with biochemical studies have revealed that the IRES substitutes for the activities of translation-initiation factors by binding and inducing conformational changes in the 40S ribosomal subunit. Direct interactions of the IRES with initiation factor eIF3 are also crucial for efficient translation initiation, providing clues to the role of eIF3 in protein synthesis.

Subjects

HEPATITIS C; VIRAL hepatitis; RIBOSOMES; ORGANELLES; VIRAL proteins; MICROBIAL proteins; MESSENGER RNA; MICROBIOLOGY

Publication

Nature Reviews Microbiology, 2007, Vol 5, Issue 1, p29

ISSN

1740-1526

Publication type

Academic Journal

DOI

10.1038/nrmicro1558