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- Title
N<sup>6</sup>-methyl-adenine: an epigenetic signal for DNA–protein interactions.
- Authors
Wion, Didier; Casadesús, Josep
- Abstract
N6-methyl-adenine is found in the genomes of bacteria, archaea, protists and fungi. Most bacterial DNA adenine methyltransferases are part of restriction–modification systems. Certain groups of Proteobacteria also harbour solitary DNA adenine methyltransferases that provide signals for DNA–protein interactions. In γ-proteobacteria, Dam methylation regulates chromosome replication, nucleoid segregation, DNA repair, transposition of insertion elements and transcription of specific genes. In Salmonella, Haemophilus, Yersinia and Vibrio species and in pathogenic Escherichia coli, Dam methylation is required for virulence. In α-proteobacteria, CcrM methylation regulates the cell cycle in Caulobacter, Rhizobium and Agrobacterium, and has a role in Brucella abortus infection.
- Subjects
ADENINE; METHYLATION; DNA-protein interactions; GENOMES; BACTERIA; CELL cycle regulation; MICROBIOLOGY
- Publication
Nature Reviews Microbiology, 2006, Vol 4, Issue 3, p183
- ISSN
1740-1526
- Publication type
Academic Journal
- DOI
10.1038/nrmicro1350