Results
Title

RNA decay: Stabilizing stemness through m<sup>6</sup>A.

Authors

Minton, Kirsty

Abstract

The article focuses on the findings of the study which states the requirement of N-methyladenosine as the most frequent internal modification of mRNA to keep the properties of mouse embryonic stem (ES) cells. The prediction of two mammalian M6A, METTL3 and METTL14, on the basis of sequence analysis, is mentioned. It is inferred that a direct RNA methylation assay asserts METTL3 and METTL14 to function synergistically to increase M6A modification.

Subjects

EMBRYONIC stem cells; MESSENGER RNA; NUCLEIC acids; SEQUENCE analysis; METHYLATION

Publication

Nature Reviews Molecular Cell Biology, 2014, Vol 15, Issue 2, p76

ISSN

1471-0072

Publication type

Academic Journal

DOI

10.1038/nrm3745