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- Title
Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling.
- Authors
Rudd, Christopher E.; Schneider, Helga
- Abstract
Many studies have shown the central importance of the co-receptors CD28, inducible costimulatory molecule (ICOS) and cytotoxic T lymphocyte antigen 4 (CTLA4) in the regulation of many aspects of T-cell function. CD28 and ICOS have both overlapping and distinct functions in the positive regulation of T-cell responses, whereas CTLA4 negatively regulates the response. The signalling pathways that underlie the function of each of the co-receptors indicate their shared and unique properties and provide compelling hints of functions that are as yet uncovered. Here, we outline the shared and distinct signalling events that are associated with each of the co-receptors and provide unifying concepts that are related to signalling functions of these co-receptors.
- Subjects
CELL receptors; T cells; ANTIGENS; CELL death; CELLS
- Publication
Nature Reviews Immunology, 2003, Vol 3, Issue 7, p544
- ISSN
1474-1733
- Publication type
Academic Journal
- DOI
10.1038/nri1131