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- Title
Regulation of IL4 gene expression by T cells and therapeutic perspectives.
- Authors
Li-Weber, Min; Krammer, Peter H.
- Abstract
Interleukin-4 (IL-4) is crucial for the differentiation of naive T helper (TH) cells into the TH2 effector cells that promote humoral (antibody) immunity and provide protection against intestinal helminths. IL-4 also has a central role in the pathogenesis of allergic inflammation. Many transcription factors are involved in the regulation of expression of the gene encoding IL-4. Initiation of transcription of the gene encoding IL-4 in naive TH cells is regulated by the TH2-specific transcription factor GATA3, whereas acute expression of the gene encoding IL-4 in TH2 cells is mediated by inducible, ubiquitous transcription factors after antigen encounter. This review focuses on acute activation of the gene encoding IL-4 in T cells and discusses therapeutic perspectives at the transcriptional level.
- Subjects
INTERLEUKIN-4; T cells; GENES; THERAPEUTICS; CELLS
- Publication
Nature Reviews Immunology, 2003, Vol 3, Issue 7, p534
- ISSN
1474-1733
- Publication type
Academic Journal
- DOI
10.1038/nri1128