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Designed transcription factors as structural, functional and therapeutic probes of chromatin in vivo.
Published in:
EMBO Reports, 2002, v. 3, n. 7, p. 610, doi. 10.1093/embo-reports/kvf140
By:
- Urnov, Fyodor D.;
- Rebar, Edward J.;
- Reik, Andreas;
- Pandolfi, Pier Paolo
Publication type:
Article
Genome editing with engineered zinc finger nucleases.
Published in:
2010
By:
- Urnov, Fyodor D.;
- Rebar, Edward J.;
- Holmes, Michael C.;
- Zhang, H. Steve;
- Gregory, Philip D.
Publication type:
journal article
Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.
Published in:
Molecular Therapy, 2015, v. 23, n. 8, p. 1380, doi. 10.1038/mt.2015.71
By:
- Beane, Joal D;
- Lee, Gary;
- Zheng, Zhili;
- Mendel, Matthew;
- Abate-Daga, Daniel;
- Bharathan, Mini;
- Black, Mary;
- Gandhi, Nimisha;
- Yu, Zhiya;
- Chandran, Smita;
- Giedlin, Martin;
- Ando, Dale;
- Miller, Jeff;
- Paschon, David;
- Guschin, Dmitry;
- Rebar, Edward J;
- Reik, Andreas;
- Holmes, Michael C;
- Gregory, Philip D;
- Restifo, Nicholas P
Publication type:
Article
A Designed Zinc-finger Transcriptional Repressor of Phospholamban Improves Function of the Failing Heart.
Published in:
Molecular Therapy, 2012, v. 20, n. 8, p. 1508, doi. 10.1038/mt.2012.80
By:
- Zhang, H Steve;
- Liu, Dingang;
- Huang, Yan;
- Schmidt, Stefan;
- Hickey, Reed;
- Guschin, Dmitry;
- Su, Haili;
- Jovin, Ion S;
- Kunis, Mike;
- Hinkley, Sarah;
- Liang, Yuxin;
- Hinh, Linda;
- Spratt, S Kaye;
- Case, Casey C;
- Rebar, Edward J;
- Ehrlich, Barbara;
- Gregory, Philip D;
- Giordano, Frank J
Publication type:
Article
387. Advantageous Properties of the piggyBac Transposon System for Gene Transfer in Human Cells.
Published in:
Molecular Therapy, 2006, v. 13, p. S147, doi. 10.1016/j.ymthe.2006.08.448
By:
- Wilson, Matthew H.;
- Coates, Craig J.;
- Rebar, Edward J.;
- George, Jr., Alfred L.
Publication type:
Article
555. Large-Scale, Flow-Based Electroporation To Deliver Engineered Zinc Finger Protein Nucleases That Mediate High-Efficiency Disruption of the Human CCR5 Gene.
Published in:
Molecular Therapy, 2006, v. 13, p. S214, doi. 10.1016/j.ymthe.2006.08.627
By:
- Holmes, Michael C.;
- Liu, Linda;
- Perez, Elena;
- Linhong Li;
- Shivakumar, Rama;
- Allen, Cornell;
- Olga Liu;
- Miller, Jeffrey C.;
- Urnov, Fyodor D.;
- Kim, Kenneth;
- Rebar, Edward J.;
- Ando, Dale;
- Gregory, Philip D.;
- Riley, James;
- Peshwa, Madhusudan;
- June, Carl
Publication type:
Article
758. Towards Gene Knock out Therapy for AIDS/HIV: Targeted Disruption of CCR5 Using Engineered Zinc Finger Protein Nucleases (ZFNs).
Published in:
Molecular Therapy, 2006, v. 13, p. S293, doi. 10.1016/j.ymthe.2006.08.842
By:
- Perez, Elena;
- Jouvenot, Yann;
- Miller, Jeffrey C.;
- Olga Liu;
- Jianbin Wang;
- Guschin, Dmitry;
- Bartsevich, Victor;
- Kim, Kenneth;
- Ya-Li Lee;
- Rebar, Edward J.;
- Ando, Dale;
- Gregory, Philip D.;
- Riley, James;
- Holmes, Michael C.;
- June, Carl
Publication type:
Article
787. Engineered Fok I Heterodimers for Enhanced Zinc Finger Nuclease Specificity.
Published in:
Molecular Therapy, 2006, v. 13, p. S305, doi. 10.1016/j.ymthe.2006.08.875
By:
- Miller, Jeffrey C.;
- Holmes, Michael;
- Jianbin Wang;
- Ya-Li Lee;
- Rupniewski, Igor;
- Waite, Adam;
- Guschin, Dmitry;
- Gregory, Philip;
- Pabo, Carl O.;
- Rebar, Edward J.
Publication type:
Article
1072. Superactivation of the SRα and CMV Promoters Using Designed Zinc Finger Proteins
Published in:
2005
By:
- Bartsevich, Victor V.;
- Reik, Andreas;
- Zhou, Yuanyue;
- Kong, Michelle;
- Li, Xiao-Yong;
- Warfe, Lyndon;
- Zhang, Lei;
- Case, Casey C.;
- Collingwood, Trevor;
- Gregory, Philip D.;
- Rebar, Edward J.
Publication type:
Abstract
974. Towards Gene Knock out Therapy for AIDS/HIV: Targeted Disruption of CCR5 Using Engineered Zinc Finger Protein Nucleases (ZFNs)
Published in:
2005
By:
- Jouvenot, Yann;
- Perez, Elena;
- Urnov, Fyodor D.;
- Beausejour, Christian;
- Rock, Jeremy;
- Lee, Ya-Li;
- Miller, Jeffrey C.;
- Rebar, Edward J.;
- Holmes, Michael C.;
- Ando, Dale;
- Riley, Jim;
- Gregory, Philip D.;
- June, Carl
Publication type:
Abstract
379. New Zinc Finger Protein Nuclease Architectures for More Efficient Gene Modification Therapies
Published in:
2005
By:
- Miller, Jeffrey C.;
- Zhang, Lei;
- Urnov, Fyodor D.;
- Patterson, Sarah;
- Xia, Danny;
- Rock, Jeremy;
- Augustus, Sheldon;
- Pabo, Carl O.;
- Gregory, Philip D.;
- Rebar, Edward J.;
- Holmes, Michael C.
Publication type:
Abstract
85. Development of Zinc Finger Nucleases for Therapeutic Gene Correction of Sickle Cell Anemia
Published in:
2005
By:
- Miller, Jeffrey C.;
- Urnov, Fyodor D.;
- Lee, Ya-li;
- Rock, Jeremy;
- Sorba, Tyler;
- Patterson, Sarah;
- Gregory, Philip D.;
- Holmes, Michael C.;
- Rebar, Edward J.
Publication type:
Abstract
43. Targeting the Biology of Heart Disease: Engineered Zinc Finger Protein Repressors of Phospholamban as a Potential Therapy for Congestive Heart Failure
Published in:
2005
By:
- Zhang, H. Steve;
- Zhang, Lei;
- Huang, Yan;
- Liu, Dinggang;
- Liang, Yuxin;
- Hickey, Reed;
- Guschin, Dmitry;
- Chandler, Simon;
- Kunis, Mike;
- Hinh, Linda;
- Xia, Danny;
- Zhong, Xiaohong;
- Spratt, S. Kaye;
- Martin, J. Tyler;
- Case, Casey C.;
- Ando, Dale;
- Rebar, Edward J.;
- Gregory, Philip D.;
- Giordano, Frank
Publication type:
Abstract
Transcriptional activation of Brassica napusβ-ketoacyl-ACP synthase II with an engineered zinc finger protein transcription factor.
Published in:
Plant Biotechnology Journal, 2012, v. 10, n. 7, p. 783, doi. 10.1111/j.1467-7652.2012.00695.x
By:
- Gupta, Manju;
- DeKelver, Russell C.;
- Palta, Asha;
- Clifford, Carla;
- Gopalan, Sunita;
- Miller, Jeffrey C.;
- Novak, Stephen;
- Desloover, Daniel;
- Gachotte, Daniel;
- Connell, James;
- Flook, Josh;
- Patterson, Thomas;
- Robbins, Kelly;
- Rebar, Edward J.;
- Gregory, Philip D.;
- Urnov, Fyodor D.;
- Petolino, Joseph F.
Publication type:
Article
Enhanced protein production by engineered zinc finger proteins.
Published in:
Biotechnology & Bioengineering, 2007, v. 97, n. 5, p. 1180, doi. 10.1002/bit.21304
By:
- Reik, Andreas;
- Zhou, Yuanyue;
- Collingwood, Trevor N.;
- Warfe, Lyndon;
- Bartsevich, Victor;
- Kong, Yanhong;
- Henning, Karla A.;
- Fallentine, Barrett K.;
- Zhang, Lei;
- Zhong, Xiaohong;
- Jouvenot, Yann;
- Jamieson, Andrew C.;
- Rebar, Edward J.;
- Case, Casey C.;
- Korman, Alan;
- Li, Xiao-Yong;
- Black, Amelia;
- King, David J.;
- Gregory, Philip D.
Publication type:
Article
Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations.
Published in:
EMBO Molecular Medicine, 2014, v. 6, n. 4, p. 458, doi. 10.1002/emmm.201303672
By:
- Gammage, Payam A;
- Rorbach, Joanna;
- Vincent, Anna I;
- Rebar, Edward J;
- Minczuk, Michal
Publication type:
Article
Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases.
Published in:
PLoS Pathogens, 2011, v. 7, n. 4, p. 1, doi. 10.1371/journal.ppat.1002020
By:
- Wilen, Craig B.;
- Wang, Jianbin;
- Tilton, John C.;
- Miller, Jeffrey C.;
- Kim, Kenneth A.;
- Rebar, Edward J.;
- Sherrill-Mix, Scott A.;
- Patro, Sean C.;
- Secreto, Anthony J.;
- Jordan, Andrea P. O.;
- Lee, Gary;
- Kahn, Joshua;
- Aye, Pyone P.;
- Bunnell, Bruce A.;
- Lackner, Andrew A.;
- Hoxie, James A.;
- Danet-Desnoyers, Gwenn A.;
- Bushman, Frederic D.;
- Riley, James L.;
- Gregory, Philip D.
Publication type:
Article
Translating dosage compensation to trisomy 21.
Published in:
Nature, 2013, v. 500, n. 7462, p. 296, doi. 10.1038/nature12394
By:
- Jiang, Jun;
- Jing, Yuanchun;
- Cost, Gregory J.;
- Chiang, Jen-Chieh;
- Kolpa, Heather J.;
- Cotton, Allison M.;
- Carone, Dawn M.;
- Carone, Benjamin R.;
- Shivak, David A.;
- Guschin, Dmitry Y.;
- Pearl, Jocelynn R.;
- Rebar, Edward J.;
- Byron, Meg;
- Gregory, Philip D.;
- Brown, Carolyn J.;
- Urnov, Fyodor D.;
- Hall, Lisa L.;
- Lawrence, Jeanne B.
Publication type:
Article
In vivo genome editing restores haemostasis in a mouse model of haemophilia.
Published in:
Nature, 2011, v. 475, n. 7355, p. 217, doi. 10.1038/nature10177
By:
- Hojun Li;
- Haurigot, Virginia;
- Doyon, Yannick;
- Tianjian Li;
- Wong, Sunnie Y.;
- Bhagwat, Anand S.;
- Malani, Nirav;
- Anguela, Xavier M.;
- Sharma, Rajiv;
- Ivanciu, Lacramiora;
- Murphy, Samuel L.;
- Finn, Jonathan D.;
- Khazi, Fayaz R.;
- Shangzhen Zhou;
- Paschon, David E.;
- Rebar, Edward J.;
- Bushman, Frederic D.;
- Gregory, Philip D.;
- Holmes, Michael C.;
- High, Katherine A.
Publication type:
Article
Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing.
Published in:
Nature Communications, 2016, v. 7, n. 1, p. 10194, doi. 10.1038/ncomms10194
By:
- Oakes, Benjamin L.;
- Xia, Danny F.;
- Rowland, Elizabeth F.;
- Xu, Denise J.;
- Ankoudinova, Irina;
- Borchardt, Jennifer S.;
- Zhang, Lei;
- Li, Patrick;
- Miller, Jeffrey C.;
- Rebar, Edward J.;
- Noyes, Marcus B.
Publication type:
Article
Enhancing gene editing specificity by attenuating DNA cleavage kinetics.
Published in:
Nature Biotechnology, 2019, v. 37, n. 8, p. 945, doi. 10.1038/s41587-019-0186-z
By:
- Miller, Jeffrey C.;
- Patil, Deepak P.;
- Xia, Danny F.;
- Paine, Charles B.;
- Fauser, Friedrich;
- Richards, Hunter W.;
- Shivak, David A.;
- Bendaña, Yuri R.;
- Hinkley, Sarah J.;
- Scarlott, Nicholas A.;
- Lam, Stephen C.;
- Reik, Andreas;
- Zhou, Yuanyue;
- Paschon, David E.;
- Li, Patrick;
- Wangzor, Tenzin;
- Lee, Gary;
- Zhang, Lei;
- Rebar, Edward J.
Publication type:
Article
Induction of angiogenesis in a mouse model using engineered transcription factors.
Published in:
Nature Medicine, 2002, v. 8, n. 12, p. 1427, doi. 10.1038/nm1202-795
By:
- Rebar, Edward J.;
- Huang, Yan;
- Hickey, Reed;
- Nath, Anjali K.;
- Meoli, David;
- Nath, Sameer;
- Chen, Bingliang;
- Xu, Lei;
- Liang, Yuxin;
- Jamieson, Andrew C.;
- Zhang, Lei;
- Spratt, S Kaye;
- Case, Casey C.;
- Wolffe, Alan;
- Giordano, Frank J.
Publication type:
Article
An Engineered Zinc Finger Protein Activator of the Endogenous Glial Cell Line-Derived Neurotrophic Factor Gene Provides Functional Neuroprotection in a Rat Model of Parkinson's Disease.
Published in:
Journal of Neuroscience, 2010, v. 30, n. 49, p. 16469, doi. 10.1523/JNEUROSCI.2440-10.2010
By:
- Laganiere, Josee;
- Keils, Adrian P.;
- Lai, Jeffrey T.;
- Guschin, Dmitry;
- Paschon, David E.;
- Xiangdong Meng;
- Fong, Lauren K.;
- Qi Yu;
- Rebar, Edward J.;
- Gregory, Philip D.;
- Bankiewicz, Krystof S.;
- Forsayeth, John;
- Zhang, H. Steve
Publication type:
Article
An Engineered Zinc Finger Protein Activator of the Endogenous Glial Cell Line-Derived Neurotrophic Factor Gene Provides Functional Neuroprotection in a Rat Model of Parkinson's Disease.
Published in:
Journal of Neuroscience, 2010, v. 30, n. 48, p. 16469, doi. 10.1523/JNEUROSCI.2440-10.2010
By:
- Laganiere, Josee;
- Kells, Adrian P.;
- Lai, Jeffrey T.;
- Guschin, Dmitry;
- Paschon, David E.;
- Xiangdong Meng;
- Fong, Lauren K.;
- Qi Yu;
- Rebar, Edward J.;
- Gregory, Philip D.;
- Bankiewicz, Krystof S.;
- Forsayeth, John;
- Zhang, H. Steve
Publication type:
Article
Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases.
Published in:
Nature Methods, 2012, v. 9, n. 10, p. 993, doi. 10.1038/nmeth.2143
By:
- Straimer, Judith;
- Lee, Marcus C S;
- Lee, Andrew H;
- Zeitler, Bryan;
- Williams, April E;
- Pearl, Jocelynn R;
- Zhang, Lei;
- Rebar, Edward J;
- Gregory, Philip D;
- Llinás, Manuel;
- Urnov, Fyodor D;
- Fidock, David A
Publication type:
Article
DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation.
Published in:
PLoS Genetics, 2011, v. 7, n. 6, p. 1, doi. 10.1371/journal.pgen.1002080
By:
- Simsek, Deniz;
- Brunet, Erika;
- Sunnie Yan-Wai Wong;
- Katyal, Sachin;
- Yankun Gao;
- McKinnon, Peter J.;
- Lou, Jacqueline;
- Lei Zhang;
- Li, James;
- Rebar, Edward J.;
- Gregory, Philip D.;
- Holmes, Michael C.;
- Jasin, Maria
Publication type:
Article
Gene Transfer of an Engineered Transcription Factor Promoting Expression of VEGF-A Protects Against Experimental Diabetic Neuropathy.
Published in:
Diabetes, 2006, v. 55, n. 6, p. 1847, doi. 10.2337/db05-1060
By:
- Price, Sally A.;
- Dent, Carolyn;
- Duran-Jimenez, Beatriz;
- Liang, Yuxin;
- Zhang, Lei;
- Rebar, Edward J.;
- Case, Casey C.;
- Gregory, Philip D.;
- Martin, Tyler J.;
- Spratt, S. Kaye;
- Tomlinson, David R.
Publication type:
Article
Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells.
Published in:
Nature Cell Biology, 2011, v. 13, n. 3, p. 331, doi. 10.1038/ncb2175
By:
- Doyon, Jeffrey B.;
- Zeitler, Bryan;
- Cheng, Jackie;
- Cheng, Aaron T.;
- Cherone, Jennifer M.;
- Santiago, Yolanda;
- Lee, Andrew H.;
- Vo, Thuy D.;
- Doyon, Yannick;
- Miller, Jeffrey C.;
- Paschon, David E.;
- Lei Zhang;
- Rebar, Edward J.;
- Gregory, Philip D.;
- Urnov, Fyodor D.;
- Drubin, David G.
Publication type:
Article
Genetic engineering of human pluripotent cells using TALE nucleases.
Published in:
Nature Biotechnology, 2011, v. 29, n. 8, p. 731, doi. 10.1038/nbt.1927
By:
- Hockemeyer, Dirk;
- Wang, Haoyi;
- Kiani, Samira;
- Lai, Christine S;
- Gao, Qing;
- Cassady, John P;
- Cost, Gregory J;
- Zhang, Lei;
- Santiago, Yolanda;
- Miller, Jeffrey C;
- Zeitler, Bryan;
- Cherone, Jennifer M;
- Meng, Xiangdong;
- Hinkley, Sarah J;
- Rebar, Edward J;
- Gregory, Philip D;
- Urnov, Fyodor D;
- Jaenisch, Rudolf
Publication type:
Article
A TALE nuclease architecture for efficient genome editing.
Published in:
Nature Biotechnology, 2011, v. 29, n. 2, p. 143, doi. 10.1038/nbt.1755
By:
- Miller, Jeffrey C.;
- Siyuan Tan;
- Guijuan Qiao;
- Barlow, Kyle A.;
- Jianbin Wang;
- Xia, Danny F.;
- Xiangdong Meng;
- Paschon, David E.;
- Elo Leung;
- Hinkley, Sarah J.;
- Dulay, Gladys P.;
- Hua, Kevin L.;
- Ankoudinova, Irina;
- Cost, Gregory J.;
- Urnov, Fyodor D.;
- Zhang, H. Steve;
- Holmes, Michael C.;
- Lei Zhang;
- Gregory, Philip D.;
- Rebar, Edward J.
Publication type:
Article
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases.
Published in:
Nature Biotechnology, 2009, v. 27, n. 9, p. 851, doi. 10.1038/nbt.1562
By:
- Hockemeyer, Dirk;
- Soldner, Frank;
- Beard, Caroline;
- Qing Gao;
- Mitalipova, Maisam;
- DeKelver, Russell C.;
- Katibah, George E.;
- Amora, Ranier;
- Boydston, Elizabeth A.;
- Zeitler, Bryan;
- Xiangdong Meng;
- Miller, Jeffrey C.;
- Lei Zhang;
- Rebar, Edward J.;
- Gregory, Philip D.;
- Urnov, Fyodor D.;
- Jaenisch, Rudolf
Publication type:
Article
Establishment of HIV-1 resistance in CD4<sup>+</sup> T cells by genome editing using zinc-finger nucleases.
Published in:
Nature Biotechnology, 2008, v. 26, n. 7, p. 808, doi. 10.1038/nbt1410
By:
- Perez, Elena E;
- Wang, Jianbin;
- Miller, Jeffrey C;
- Jouvenot, Yann;
- Kim, Kenneth A;
- Liu, Olga;
- Wang, Nathaniel;
- Lee, Gary;
- Bartsevich, Victor V;
- Lee, Ya-Li;
- Guschin, Dmitry Y;
- Rupniewski, Igor;
- Waite, Adam J;
- Carpenito, Carmine;
- Carroll, Richard G;
- S Orange, Jordan;
- Urnov, Fyodor D;
- Rebar, Edward J;
- Ando, Dale;
- Gregory, Philip D
Publication type:
Article
Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases.
Published in:
Nature Biotechnology, 2008, v. 26, n. 6, p. 702, doi. 10.1038/nbt1409
By:
- Doyon, Yannick;
- McCammon, Jasmine M;
- Miller, Jeffrey C;
- Faraji, Farhoud;
- Ngo, Catherine;
- Katibah, George E;
- Amora, Rainier;
- Hocking, Toby D;
- Zhang, Lei;
- Rebar, Edward J;
- Gregory, Philip D;
- Urnov, Fyodor D;
- Amacher, Sharon L
Publication type:
Article
An improved zinc-finger nuclease architecture for highly specific genome editing.
Published in:
Nature Biotechnology, 2007, v. 25, n. 7, p. 778, doi. 10.1038/nbt1319
By:
- Miller, Jeffrey C.;
- Holmes, Michael C.;
- Jianbin Wang;
- Guschin, Dmitry Y.;
- Ya-Li Lee;
- Rupniewski, Igor;
- Beausejour, Christian M.;
- Waite, Adam J.;
- Wang, Nathaniel S.;
- Kim, Kenneth A.;
- Gregory, Philip D.;
- Pabo, Carl O.;
- Rebar, Edward J.
Publication type:
Article
Genetic editing of HLA expression in hematopoietic stem cells to broaden their human application.
Published in:
Scientific Reports, 2016, p. 21757, doi. 10.1038/srep21757
By:
- Torikai, Hiroki;
- Mi, Tiejuan;
- Gragert, Loren;
- Maiers, Martin;
- Najjar, Amer;
- Ang, Sonny;
- Maiti, Sourindra;
- Dai, Jianliang;
- Switzer, Kirsten C.;
- Huls, Helen;
- Dulay, Gladys P.;
- Reik, Andreas;
- Rebar, Edward J.;
- Holmes, Michael C.;
- Gregory, Philip D.;
- Champlin, Richard E.;
- Shpall, Elizabeth J.;
- Cooper, Laurence J. N.
Publication type:
Article
Mammalian interspecies substitution of immune modulatory alleles by genome editing.
Published in:
Scientific Reports, 2016, p. 21645, doi. 10.1038/srep21645
By:
- Lillico, Simon G.;
- Proudfoot, Chris;
- King, Tim J.;
- Tan, Wenfang;
- Zhang, Lei;
- Mardjuki, Rachel;
- Paschon, David E.;
- Rebar, Edward J.;
- Urnov, Fyodor D.;
- Mileham, Alan J.;
- McLaren, David G.;
- Whitelaw, C. Bruce A.
Publication type:
Article
Diversifying the structure of zinc finger nucleases for high-precision genome editing.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-08867-x
By:
- Paschon, David E.;
- Lussier, Stephanie;
- Wangzor, Tenzin;
- Xia, Danny F.;
- Li, Patrick W.;
- Hinkley, Sarah J.;
- Scarlott, Nicholas A.;
- Lam, Stephen C.;
- Waite, Adam J.;
- Truong, Lynn N.;
- Gandhi, Nimisha;
- Kadam, Bhakti N.;
- Patil, Deepak P.;
- Shivak, David A.;
- Lee, Gary K.;
- Holmes, Michael C.;
- Zhang, Lei;
- Miller, Jeffrey C.;
- Rebar, Edward J.
Publication type:
Article

Found: 37