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- Title
Deconstructing repression: evolving models of co-repressor action.
- Authors
Perissi, Valentina; Jepsen, Kristen; Glass, Christopher K.; Rosenfeld, Michael G.
- Abstract
A crucial aspect of development, homeostasis and prevention of disease is the strict maintenance of patterns of gene repression. Gene repression is largely achieved by the combinatorial action of various enzymatic complexes - known as co-repressor complexes - that are recruited to DNA by transcription factors and often act through enzymatic modification of histone protein tails. Our understanding of how co-repressors act has begun to change over recent years owing to the increased availability of genome-scale data. Here, we consider specific strategies that underlie repression events - for example, those mediated by the nuclear receptor co-repressor (NCoR, also known as NCOR1) and silencing mediator of retinoic acid and thyroid hormone receptor (SMRT, also known as NCOR2) co-repressor complexes - and discuss emerging themes in gene repression.
- Subjects
GENETIC regulation; GENETIC repressors; PREVENTIVE medicine; HOMEOSTASIS; TRANSCRIPTION factors; NUCLEAR receptors (Biochemistry); PROTEIN metabolism; BIOLOGICAL models; BINDING sites; PROTEINS; DNA; GENE expression; ANIMALS
- Publication
Nature Reviews Genetics, 2010, Vol 11, Issue 2, p109
- ISSN
1471-0056
- Publication type
Academic Journal
- DOI
10.1038/nrg2736