Works matching AU Seal, Sheila

Results: 35

IgE secretion is attenuated by an inhibitor of proteolytic processing of CD23 (FcεRII).

Published in:

European Journal of Immunology, 1997, v. 27, n. 12, p. 3228, doi. 10.1002/eji.1830271221

By:

Christie, Gary;
Barton, Aisling;
Bolognese, Brian;
Buckle, Derek R.;
Cook, Richard M.;
Hansbury, Michael J.;
Harper, Gregory P.;
Marshall, Lisa A.;
McCord, Mark E.;
Moulder, Kevin;
Murdock, Paul R.;
Seal, Sheila M.;
Spackman, Vivienne M.;
Weston, Beverley J.;
Mayer, Ruth J.

Publication type:

Article

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer.

Published in:

Nature, 2013, v. 493, n. 7432, p. 406, doi. 10.1038/nature11725

By:

Ruark, Elise;
Snape, Katie;
Humburg, Peter;
Loveday, Chey;
Bajrami, Ilirjana;
Brough, Rachel;
Rodrigues, Daniel Nava;
Renwick, Anthony;
Seal, Sheila;
Ramsay, Emma;
Duarte, Silvana Del Vecchio;
Rivas, Manuel A.;
Warren-Perry, Margaret;
Zachariou, Anna;
Campion-Flora, Adriana;
Hanks, Sandra;
Murray, Anne;
Pour, Naser Ansari;
Douglas, Jenny;
Gregory, Lorna

Publication type:

Article

Evaluation of Cancer-Based Criteria for Use in Mainstream BRCA1 and BRCA2 Genetic Testing in Patients With Breast Cancer.

Published in:

JAMA Network Open, 2019, v. 2, n. 5, p. e194428, doi. 10.1001/jamanetworkopen.2019.4428

By:

Kemp, Zoe;
Turnbull, Alice;
Yost, Shawn;
Seal, Sheila;
Mahamdallie, Shazia;
Poyastro-Pearson, Emma;
Warren-Perry, Margaret;
Eccleston, Anthony;
Tan, Min-Min;
Teo, Soo Hwang;
Turner, Nicholas;
Strydom, Ann;
George, Angela;
Rahman, Nazneen

Publication type:

Article

Absence of evidence for a familial breast cancer susceptibility gene at chromosome 8p12-p22.

Published in:

Oncogene, 2000, v. 19, n. 36, p. 4170, doi. 10.1038/sj.onc.1203735

By:

Rahman, Nazneen;
Teare, M Dawn;
Seal, Sheila;
Renard, Helene;
Mangion, Jon;
Cour, Chantal;
Thompson, Deborah;
Shugart, Yin;
Eccles, Diana;
Devilee, Peter;
Meijers, Hanne;
Nathanson, Katherine L;
Neuhausen, Susan L;
Weber, Barbara;
Chang-Claude, Jenny;
Easton, Douglas F;
Goldgar, David;
Stratton, Michael R

Publication type:

Article

Evaluation of RAD50 in familial breast cancer predisposition.

Published in:

International Journal of Cancer, 2006, v. 118, n. 11, p. 2911, doi. 10.1002/ijc.21738

By:

Tommiska, Johanna;
Seal, Sheila;
Renwick, Anthony;
Barfoot, Rita;
Baskcomb, Linda;
Jayatilake, Hiran;
Bartkova, Jirina;
Tallila, Jonna;
Kaare, Milja;
Tamminen, Anitta;
Heikkilä, Päivi;
Evans, D. Gareth;
Eccles, Diana;
Aittomäki, Kristiina;
Blomqvist, Carl;
Bartek, Jiri;
Stratton, Michael R.;
Nevanlinna, Heli;
Rahman, Nazneen

Publication type:

Article

Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer.

Published in:

Nature Genetics, 2007, v. 39, n. 2, p. 162, doi. 10.1038/ng1947

By:

Reid, Sarah;
Schindler, Detlev;
Hanenberg, Helmut;
Barker, Karen;
Hanks, Sandra;
Kalb, Reinhard;
Neveling, Kornelia;
Kelly, Patrick;
Seal, Sheila;
Freund, Marcel;
Wurm, Melanie;
Batish, Sat Dev;
Lach, Francis P.;
Yetgin, Sevgi;
Neitzel, Heidemarie;
Ariffin, Hany;
Tischkowitz, Marc;
Mathew, Christopher G.;
Auerbach, Arleen D.;
Rahman, Nazneen

Publication type:

Article

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene.

Published in:

Nature Genetics, 2007, v. 39, n. 2, p. 165, doi. 10.1038/ng1959

By:

Rahman, Nazneen;
Seal, Sheila;
Thompson, Deborah;
Kelly, Patrick;
Renwick, Anthony;
Elliott, Anna;
Reid, Sarah;
Spanova, Katarina;
Barfoot, Rita;
Chagtai, Tasnim;
Jayatilake, Hiran;
McGuffog, Lesley;
Hanks, Sandra;
Evans, D. Gareth;
Eccles, Diana;
Easton, Douglas F.;
Stratton, Michael R.

Publication type:

Article

Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles.

Published in:

Nature Genetics, 2006, v. 38, n. 11, p. 1239, doi. 10.1038/ng1902

By:

Seal, Sheila;
Thompson, Deborah;
Renwick, Anthony;
Elliott, Anna;
Kelly, Patrick;
Barfoot, Rita;
Chagtai, Tasnim;
Jayatilake, Hiran;
Ahmed, Munaza;
Spanova, Katarina;
North, Bernard;
McGuffog, Lesley;
Evans, D. Gareth;
Eccles, Diana;
Easton, Douglas F.;
Stratton, Michael R.;
Rahman, Nazneen

Publication type:

Article

ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles.

Published in:

Nature Genetics, 2006, v. 38, n. 8, p. 873, doi. 10.1038/ng1837

By:

Renwick, Anthony;
Thompson, Deborah;
Seal, Sheila;
Kelly, Patrick;
Chagtai, Tasnim;
Ahmed, Munaza;
North, Bernard;
Jayatilake, Hiran;
Barfoot, Rita;
Spanova, Katarina;
McGuffog, Lesley;
Evans, D. Gareth;
Eccles, Diana;
Easton, Douglas F.;
Stratton, Michael R.;
Rahman, Nazneen

Publication type:

Article

Identification of the familial cylindromatosis tumour-suppressor gene.

Published in:

Nature Genetics, 2000, v. 25, n. 2, p. 160, doi. 10.1038/76006

By:

Bignell, Graham R.;
Warren, William;
Seal, Sheila;
Takahashi, Meiko;
Rapley, Elizabeth;
Barfoot, Rita;
Green, Helen;
Brown, Carolanne;
Biggs, Patrick J.;
Lakhani, Sunil R.;
Jones, Christopher;
Hansen, Juliana;
Blair, Edward;
Hofmann, Benedikt;
Siebert, Reiner;
Turner, Gwen;
Evans, D. Gareth;
Schrander-Stumpel, Connie;
Beemer, Frits A.

Publication type:

Article

Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours.

Published in:

Nature Genetics, 2000, v. 24, n. 2, p. 197, doi. 10.1038/72877

By:

Rapley, Elizabeth A.;
Crockford, Gillian P.;
Teare, Dawn;
Biggs, Patrick;
Seal, Sheila;
Barfoot, Rita;
Edwards, Sandra;
Hamoudi, Rifat;
Heimdal, Ketil;
Fosså, Sophie D.;
Tucker, Kathy;
Donald, Jenny;
Collins, Felicity;
Friedlander, Michael;
Hogg, David;
Goss, Paul;
Heidenreich, Axel;
Ormiston, Wilma;
Daly, Peter A.

Publication type:

Article

A pilot study investigating feasibility of mainstreaming germline BRCA1 and BRCA2 testing in high-risk patients with breast and/or ovarian cancer in three tertiary Cancer Centres in Ireland.

Published in:

Familial Cancer, 2023, v. 22, n. 2, p. 135, doi. 10.1007/s10689-022-00313-0

By:

McVeigh, Terri Patricia;
Sweeney, Karl J.;
Brennan, Donal J.;
McVeigh, Una M.;
Ward, Simon;
Strydom, Ann;
Seal, Sheila;
Astbury, Katherine;
Donnellan, Paul;
Higgins, Joanne;
Keane, Maccon;
Kerin, Michael J.;
Malone, Carmel;
McGough, Pauline;
McLaughlin, Ray;
O'Leary, Michael;
Rushe, Margaret;
Barry, Michael Kevin;
MacGregor, Geraldine;
Sugrue, Michael

Publication type:

Article

Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer.

Published in:

1999

By:

Peto, Julian;
Collins, Nadine;
Barfoot, Rita;
Seal, Sheila;
Warren, William;
Rahman, Nazneen;
Easton, Douglas F.;
Evans, Christopher;
Deacon, Judith;
Stratton, Michael R.;
Peto, J;
Collins, N;
Barfoot, R;
Seal, S;
Warren, W;
Rahman, N;
Easton, D F;
Evans, C;
Deacon, J;
Stratton, M R

Publication type:

journal article

Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours.

Published in:

Nature Communications, 2015, v. 6, n. 1, p. 5973, doi. 10.1038/ncomms6973

By:

Litchfield, Kevin;
Summersgill, Brenda;
Yost, Shawn;
Sultana, Razvan;
Labreche, Karim;
Dudakia, Darshna;
Renwick, Anthony;
Seal, Sheila;
Al-Saadi, Reem;
Broderick, Peter;
Turner, Nicholas C.;
Houlston, Richard S.;
Huddart, Robert;
Shipley, Janet;
Turnbull, Clare

Publication type:

Article

Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour.

Published in:

Nature Communications, 2014, v. 5, n. 8, p. 4398, doi. 10.1038/ncomms5398

By:

Hanks, Sandra;
Perdeaux, Elizabeth R.;
Seal, Sheila;
Ruark, Elise;
Mahamdallie, Shazia S.;
Murray, Anne;
Ramsay, Emma;
Del Vecchio Duarte, Silvana;
Zachariou, Anna;
de Souza, Bianca;
Warren-Perry, Margaret;
Elliott, Anna;
Davidson, Alan;
Price, Helen;
Stiller, Charles;
Pritchard-Jones, Kathy;
Rahman, Nazneen

Publication type:

Article

OpEx - a validated, automated pipeline optimised for clinical exome sequence analysis.

Published in:

Scientific Reports, 2016, p. 31029, doi. 10.1038/srep31029

By:

Ruark, Elise;
Münz, Márton;
Clarke, Matthew;
Renwick, Anthony;
Ramsay, Emma;
Elliott, Anna;
Seal, Sheila;
Lunter, Gerton;
Rahman, Nazneen

Publication type:

Article

Implementing rapid, robust, cost-effective, patient-centred, routine genetic testing in ovarian cancer patients.

Published in:

Scientific Reports, 2016, p. 29506, doi. 10.1038/srep29506

By:

George, Angela;
Riddell, Daniel;
Seal, Sheila;
Talukdar, Sabrina;
Mahamdallie, Shazia;
Ruark, Elise;
Cloke, Victoria;
Slade, Ingrid;
Kemp, Zoe;
Gore, Martin;
Strydom, Ann;
Banerjee, Susana;
Hanson, Helen;
Rahman, Nazneen

Publication type:

Article

Multi-stage genome-wide association study identifies new susceptibility locus for testicular germ cell tumour on chromosome 3q25.

Published in:

Human Molecular Genetics, 2015, v. 24, n. 4, p. 1169, doi. 10.1093/hmg/ddu511

By:

Litchfield, Kevin;
Sultana, Razvan;
Renwick, Anthony;
Dudakia, Darshna;
Seal, Sheila;
Ramsay, Emma;
Powell, Silvana;
Elliott, Anna;
Warren-Perry, Margaret;
Eeles, Rosalind;
Peto, Julian;
Kote-Jarai, Zsofia;
Muir, Kenneth;
Nsengimana, Jeremie;
Stratton, Michael R.;
Easton, Douglas F.;
Bishop, D. Timothy;
Huddart, Robert A.;
Rahman, Nazneen;
Turnbull, Clare

Publication type:

Article

Gene–gene interactions in breast cancer susceptibility.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 4, p. 958

By:

Turnbull, Clare;
Seal, Sheila;
Renwick, Anthony;
Warren-Perry, Margaret;
Hughes, Deborah;
Elliott, Anna;
Pernet, David;
Peock, Susan;
Adlard, Julian W.;
Barwell, Julian;
Berg, Jonathan;
Brady, Angela F.;
Brewer, Carole;
Brice, Glen;
Chapman, Cyril;
Cook, Jackie;
Davidson, Rosemarie;
Donaldson, Alan;
Douglas, Fiona;
Greenhalgh, Lynn

Publication type:

Article

CSN and CAVA: variant annotation tools for rapid, robust next-generation sequencing analysis in the clinical setting.

Published in:

Genome Medicine, 2015, v. 7, n. 1, p. 1, doi. 10.1186/s13073-015-0195-6

By:

Münz, Márton;
Ruark, Elise;
Renwick, Anthony;
Ramsay, Emma;
Clarke, Matthew;
Mahamdallie, Shazia;
Cloke, Victoria;
Seal, Sheila;
Strydom, Ann;
Lunter, Gerton;
Rahman, Nazneen

Publication type:

Article

Corrigendum: Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability.

Published in:

Nature Genetics, 2014, v. 46, n. 6, p. 657, doi. 10.1038/ng0614-657c

By:

Tatton-Brown, Katrina;
Seal, Sheila;
Ruark, Elise;
Harmer, Jenny;
Ramsay, Emma;
del Vecchio Duarte, Silvana;
Zachariou, Anna;
Hanks, Sandra;
O'Brien, Eleanor;
Aksglaede, Lise;
Baralle, Diana;
Dabir, Tabib;
Gener, Blanca;
Goudie, David;
Homfray, Tessa;
Kumar, Ajith;
Pilz, Daniela T;
Selicorni, Angelo;
Temple, I Karen;
Van Maldergem, Lionel

Publication type:

Article

Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability.

Published in:

Nature Genetics, 2014, v. 46, n. 4, p. 385, doi. 10.1038/ng.2917

By:

Tatton-Brown, Katrina;
Seal, Sheila;
Ruark, Elise;
Harmer, Jenny;
Ramsay, Emma;
del Vecchio Duarte, Silvana;
Zachariou, Anna;
Hanks, Sandra;
O'Brien, Eleanor;
Aksglaede, Lise;
Baralle, Diana;
Dabir, Tabib;
Gener, Blanca;
Goudie, David;
Homfray, Tessa;
Kumar, Ajith;
Pilz, Daniela T;
Selicorni, Angelo;
Temple, I Karen;
Van Maldergem, Lionel

Publication type:

Article

A genome-wide association study identifies susceptibility loci for Wilms tumor.

Published in:

Nature Genetics, 2013, v. 45, n. 8, p. 962, doi. 10.1038/ng0813-962a

By:

Turnbull, Clare;
Perdeaux, Elizabeth R;
Pernet, David;
Naranjo, Arlene;
Renwick, Anthony;
Seal, Sheila;
Munoz-Xicola, Rosa Maria;
Hanks, Sandra;
Slade, Ingrid;
Zachariou, Anna;
Warren-Perry, Margaret;
Ruark, Elise;
Gerrard, Mary;
Hale, Juliet;
Hewitt, Martin;
Kohler, Janice;
Lane, Sheila;
Levitt, Gill;
Madi, Mabrook;
Morland, Bruce

Publication type:

Article

Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.

Published in:

Nature Genetics, 2013, v. 45, n. 6, p. 686, doi. 10.1038/ng.2635

By:

Ruark, Elise;
Seal, Sheila;
McDonald, Heather;
Zhang, Feng;
Elliot, Anna;
Lau, KingWai;
Perdeaux, Elizabeth;
Rapley, Elizabeth;
Eeles, Rosalind;
Peto, Julian;
Kote-Jarai, Zsofia;
Muir, Kenneth;
Nsengimana, Jeremie;
Shipley, Janet;
Bishop, D Timothy;
Stratton, Michael R;
Easton, Douglas F;
Huddart, Robert A;
Rahman, Nazneen;
Turnbull, Clare

Publication type:

Article

A genome-wide association study identifies susceptibility loci for Wilms tumor.

Published in:

Nature Genetics, 2012, v. 44, n. 7, p. 831, doi. 10.1038/ng0712-831c

By:

Turnbull, Clare;
Perdeaux, Elizabeth R;
Pernet, David;
Naranjo, Arlene;
Renwick, Anthony;
Seal, Sheila;
Munoz-Xicola, Rosa Maria;
Hanks, Sandra;
Slade, Ingrid;
Zachariou, Anna;
Warren-Perry, Margaret;
Ruark, Elise;
Gerrard, Mary;
Hale, Juliet;
Hewitt, Martin;
Kohler, Janice;
Lane, Sheila;
Levitt, Gill;
Madi, Mabrook;
Morland, Bruce

Publication type:

Article

A genome-wide association study identifies susceptibility loci for Wilms tumor.

Published in:

Nature Genetics, 2012, v. 44, n. 6, p. 681, doi. 10.1038/ng.2251

By:

Turnbull, Clare;
Perdeaux, Elizabeth R;
Pernet, David;
Naranjo, Arlene;
Renwick, Anthony;
Seal, Sheila;
Munoz-Xicola, Rosa Maria;
Hanks, Sandra;
Slade, Ingrid;
Zachariou, Anna;
Warren-Perry, Margaret;
Ruark, Elise;
Gerrard, Mary;
Hale, Juliet;
Hewitt, Martin;
Kohler, Janice;
Lane, Sheila;
Levitt, Gill;
Madi, Mabrook;
Morland, Bruce

Publication type:

Article

Germline RAD51C mutations confer susceptibility to ovarian cancer.

Published in:

Nature Genetics, 2012, v. 44, n. 5, p. 475, doi. 10.1038/ng.2224

By:

Loveday, Chey;
Turnbull, Clare;
Ruark, Elise;
Xicola, Rosa Maria Munoz;
Ramsay, Emma;
Hughes, Deborah;
Warren-Perry, Margaret;
Snape, Katie;
Eccles, Diana;
Evans, D Gareth;
Gore, Martin;
Renwick, Anthony;
Seal, Sheila;
Antoniou, Antonis C;
Rahman, Nazneen

Publication type:

Article

Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.

Published in:

Nature Genetics, 2010, v. 42, n. 7, p. 604, doi. 10.1038/ng.607

By:

Turnbull, Clare;
Rapley, Elizabeth A;
Seal, Sheila;
Pernet, David;
Renwick, Anthony;
Hughes, Deborah;
Ricketts, Michelle;
Linger, Rachel;
Nsengimana, Jeremie;
Deloukas, Panagiotis;
Collaboration, UK Testicular Cancer;
Huddart, Robert A;
Bishop, D Timothy;
Easton, Douglas F;
Stratton, Michael R;
Rahman, Nazneen

Publication type:

Article

Genome-wide association study identifies five new breast cancer susceptibility loci.

Published in:

Nature Genetics, 2010, v. 42, n. 6, p. 504, doi. 10.1038/ng.586

By:

Turnbull, Clare;
Ahmed, Shahana;
Morrison, Jonathan;
Pernet, David;
Renwick, Anthony;
Maranian, Mel;
Seal, Sheila;
Ghoussaini, Maya;
Hines, Sarah;
Healey, Catherine S.;
Hughes, Deborah;
Warren-Perry, Margaret;
Tapper, William;
Eccles, Diana;
Evans, D. Gareth;
Hooning, Maartje;
Schutte, Mieke;
van den Ouweland, Ans;
Houlston, Richard;
Ross, Gillian

Publication type:

Article

A genome-wide association study of testicular germ cell tumor.

Published in:

Nature Genetics, 2009, v. 41, n. 7, p. 807, doi. 10.1038/ng.394

By:

Rapley, Elizabeth A.;
Turnbull, Clare;
Al Olama, Ali Amin;
Dermitzakis, Emmanouil T.;
Linger, Rachel;
Huddart, Robert A.;
Renwick, Anthony;
Hughes, Deborah;
Hines, Sarah;
Seal, Sheila;
Morrison, Jonathan;
Nsengimana, Jeremie;
Deloukas, Panagiotis;
Rahman, Nazneen;
Bishop, D. Timothy;
Easton, Douglas F;
Stratton, Michael R.

Publication type:

Article

Predisposition gene identification in common cancers by exome sequencing: insights from familial breast cancer.

Published in:

2012

By:

Snape, Katie;
Ruark, Elise;
Tarpey, Patrick;
Renwick, Anthony;
Turnbull, Clare;
Seal, Sheila;
Murray, Anne;
Hanks, Sandra;
Douglas, Jenny;
Stratton, Michael;
Rahman, Nazneen

Publication type:

Report

Mutation and association analysis of GEN1 in breast cancer susceptibility.

Published in:

2011

By:

Turnbull, Clare;
Hines, Sarah;
Renwick, Anthony;
Hughes, Deborah;
Pernet, David;
Elliott, Anna;
Seal, Sheila;
Warren-Perry, Margaret;
Gareth Evans, D.;
Eccles, Diana;
Stratton, Michael;
Rahman, Nazneen

Publication type:

Report

Exploring the link between MORF4L1 and risk of breast cancer.

Published in:

Breast Cancer Research, 2011, v. 13, n. 3, p. 1, doi. 10.1186/bcr2862

By:

Martrat, Griselda;
Maxwell, Christopher A.;
Tominaga, Emiko;
Porta-de-la-Riva, Montserrat;
Bonifaci, Núria;
Gómez-Baldó, Laia;
Bogliolo, Massimo;
Lázaro, Conxi;
Blanco, Ignacio;
Brunet, Joan;
Aguilar, Helena;
Fernández-Rodríguez, Juana;
Seal, Sheila;
Renwick, Anthony;
Rahman, Nazneen;
Kühl, Julia;
Neveling, Kornelia;
Schindler, Detlev;
Ramírez, María J.;
Castellà, María

Publication type:

Article

Exploring the link between MORF4L1 and risk of breast cancer.

Published in:

Breast Cancer Research, 2011, v. 13, n. 1, p. 1, doi. 10.1186/bcr2862

By:

Martrat, Griselda;
Maxwell, Christopher A;
Tominaga, Emiko;
Porta-de-la-Riva, Montserrat;
Bonifaci, Núria;
Gómez-Baldó, Laia;
Bogliolo, Massimo;
Lázaro, Conxi;
Blanco, Ignacio;
Brunet, Joan;
Aguilar, Helena;
Fernández-Rodríguez, Juana;
Seal, Sheila;
Renwick, Anthony;
Rahman, Nazneen;
Kühl, Julia;
Neveling, Kornelia;
Schindler, Detlev;
Ramírez, María J;
Castellà, María

Publication type:

Article

Exploring the link between MORF4L1 and risk of breast cancer.

Published in:

2011

By:

Martrat, Griselda;
Maxwell, Christopher M;
Tominaga, Emiko;
Porta-de-la-Riva, Montserrat;
Bonifaci, Núria;
Gómez-Baldó, Laia;
Bogliolo, Massimo;
Lázaro, Conxi;
Blanco, Ignacio;
Brunet, Joan;
Aguilar, Helena;
Fernández-Rodríguez, Juana;
Seal, Sheila;
Renwick, Anthony;
Rahman, Nazneen;
Kühl, Julia;
Neveling, Kornelia;
Schindler, Detlev;
Ramírez, María J;
Castellà, María

Publication type:

journal article