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Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development.
Published in:
Journal of Pathology, 2015, v. 236, n. 2, p. 155, doi. 10.1002/path.4520
By:
- Weren, Robbert DA;
- Venkatachalam, Ramprasath;
- Cazier, Jean‐Baptiste;
- Farin, Henner F;
- Kets, C Marleen;
- de Voer, Richarda M;
- Vreede, Lilian;
- Verwiel, Eugène TP;
- van Asseldonk, Monique;
- Kamping, Eveline J;
- Kiemeney, Lambertus A;
- Neveling, Kornelia;
- Aben, Katja KH;
- Carvajal‐Carmona, Luis;
- Nagtegaal, Iris D;
- Schackert, Hans K;
- Clevers, Hans;
- van de Wetering, Marc;
- Tomlinson, Ian P;
- Ligtenberg, Marjolijn JL
Publication type:
Article
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.
Published in:
EMBO Reports, 2003, v. 4, n. 6, p. 609, doi. 10.1038/sj.embor.embor865
By:
- van de Wetering, Marc;
- Oving, Inna;
- Muncan, Vanesa;
- Menno Tjon Pon Fong;
- Brantjes, Helen;
- van Leenen, Dik;
- Holstege, Frank C. P.;
- Brummelkamp, Thijn R.;
- Agami, Reuven;
- Clevers, Hans
Publication type:
Article
Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening.
Published in:
eLife, 2016, p. 1, doi. 10.7554/eLife.18489
By:
- Verissimo, Carla S.;
- Overmeer, René M.;
- Ponsioen, Bas;
- Drost, Jarno;
- Mertens, Sander;
- Verlaan-Klink, Ingrid;
- van Gerwen, Bastiaan;
- van der Ven, Marieke;
- van de Wetering, Marc;
- Egan, David A.;
- Bernards, René;
- Clevers, Hans;
- Bos, Johannes L.;
- Snippert, Hugo J.
Publication type:
Article
Single-cell dissection of transcriptional heterogeneity in human colon tumors.
Published in:
Nature Biotechnology, 2011, v. 29, n. 12, p. 1120, doi. 10.1038/nbt.2038
By:
- Dalerba, Piero;
- Kalisky, Tomer;
- Sahoo, Debashis;
- Rajendran, Pradeep S;
- Rothenberg, Michael E;
- Leyrat, Anne A;
- Sim, Sopheak;
- Okamoto, Jennifer;
- Johnston, Darius M;
- Qian, Dalong;
- Zabala, Maider;
- Bueno, Janet;
- Neff, Norma F;
- Wang, Jianbin;
- Shelton, Andrew A;
- Visser, Brendan;
- Hisamori, Shigeo;
- Shimono, Yohei;
- van de Wetering, Marc;
- Clevers, Hans
Publication type:
Article
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes.
Published in:
Journal of Cell Biology, 2004, v. 166, n. 1, p. 37, doi. 10.1083/jcb.200311021
By:
- Blache, Philippe;
- van de Wetering, Marc;
- Duluc, Isabelle;
- Domon, Claire;
- Berta, Philippe;
- Freund, Jean-Noël;
- Clevers, Hans;
- Jay, Philippe
Publication type:
Article
Efficient Double Fragmentation ChIP-seq Provides Nucleotide Resolution Protein-DNA Binding Profiles.
Published in:
PLoS ONE, 2010, v. 5, n. 11, p. 1, doi. 10.1371/journal.pone.0015092
By:
- Mokry, Michal;
- Hatzis, Pantelis;
- de Bruijn, Ewart;
- Koster, Jan;
- Versteeg, Rogier;
- Schuijers, Jurian;
- van de Wetering, Marc;
- Guryev, Victor;
- Clevers, Hans;
- Cuppen, Edwin
Publication type:
Article
EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model.
Published in:
Cancers, 2021, v. 13, n. 23, p. 6072, doi. 10.3390/cancers13236072
By:
- Bleijs, Margit;
- Pleijte, Corine;
- Engels, Sem;
- Ringnalda, Femke;
- Meyer-Wentrup, Friederike;
- van de Wetering, Marc;
- Clevers, Hans
Publication type:
Article
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis.
Published in:
EMBO Journal, 2013, v. 32, n. 20, p. 2708, doi. 10.1038/emboj.2013.204
By:
- Huch, Meritxell;
- Bonfanti, Paola;
- Boj, Sylvia F;
- Sato, Toshiro;
- Loomans, Cindy J M;
- van de Wetering, Marc;
- Sojoodi, Mozhdeh;
- Li, Vivian S W;
- Schuijers, Jurian;
- Gracanin, Ana;
- Ringnalda, Femke;
- Begthel, Harry;
- Hamer, Karien;
- Mulder, Joyce;
- van Es, Johan H;
- de Koning, Eelco;
- Vries, Robert G J;
- Heimberg, Harry;
- Clevers, Hans
Publication type:
Article
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.
Published in:
EMBO Journal, 2012, v. 31, n. 14, p. 3079, doi. 10.1038/emboj.2012.166
By:
- Muñoz, Javier;
- Stange, Daniel E;
- Schepers, Arnout G;
- van de Wetering, Marc;
- Koo, Bon-Kyoung;
- Itzkovitz, Shalev;
- Volckmann, Richard;
- Kung, Kevin S;
- Koster, Jan;
- Radulescu, Sorina;
- Myant, Kevin;
- Versteeg, Rogier;
- Sansom, Owen J;
- van Es, Johan H;
- Barker, Nick;
- van Oudenaarden, Alexander;
- Mohammed, Shabaz;
- Heck, Albert J R;
- Clevers, Hans
Publication type:
Article
Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes.
Published in:
EMBO Journal, 2011, v. 30, n. 6, p. 1104, doi. 10.1038/emboj.2011.26
By:
- Schepers, Arnout G;
- Vries, Robert;
- van den Born, Maaike;
- van de Wetering, Marc;
- Clevers, Hans
Publication type:
Article
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Published in:
Nature, 2011, v. 476, n. 7360, p. 293, doi. 10.1038/nature10337
By:
- de Lau, Wim;
- Barker, Nick;
- Low, Teck Y.;
- Koo, Bon-Kyoung;
- Li, Vivian S. W.;
- Teunissen, Hans;
- Kujala, Pekka;
- Haegebarth, Andrea;
- Peters, Peter J.;
- van de Wetering, Marc;
- Stange, D. E.;
- van Es, J.;
- Guardavaccaro, Daniele;
- Schasfoort, Richard B. M.;
- Mohri, Yasuaki;
- Nishimori, Katsuhiko;
- Mohammed, Shabaz;
- Heck, Albert J. R.;
- Clevers, Hans
Publication type:
Article
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.
Published in:
Nature, 2011, v. 469, n. 7330, p. 415, doi. 10.1038/nature09637
By:
- Sato, Toshiro;
- van Es, Johan H.;
- Snippert, Hugo J.;
- Stange, Daniel E.;
- Vries, Robert G.;
- van den Born, Maaike;
- Barker, Nick;
- Shroyer, Noah F.;
- van de Wetering, Marc;
- Clevers, Hans
Publication type:
Article
Single Lgr5 stem cells build crypt?villus structures in vitro without a mesenchymal niche.
Published in:
Nature, 2009, v. 459, n. 7244, p. 262, doi. 10.1038/nature07935
By:
- Sato, Toshiro;
- Vries, Robert G.;
- Snippert, Hugo J.;
- van de Wetering, Marc;
- Barker, Nick;
- Stange, Daniel E.;
- van Es, Johan H.;
- Abo, Arie;
- Kujala, Pekka;
- Peters, Peter J.;
- Clevers, Hans
Publication type:
Article
Crypt stem cells as the cells-of-origin of intestinal cancer.
Published in:
Nature, 2009, v. 457, n. 7229, p. 608, doi. 10.1038/nature07602
By:
- Barker, Nick;
- Ridgway, Rachel A.;
- van Es, Johan H.;
- van de Wetering, Marc;
- Begthel, Harry;
- van den Born, Maaike;
- Danenberg, Esther;
- Clarke, Alan R.;
- Sansom, Owen J.;
- Clevers, Hans
Publication type:
Article
Dll1<sup>+</sup> secretory progenitor cells revert to stem cells upon crypt damage.
Published in:
Nature Cell Biology, 2012, v. 14, n. 10, p. 1099, doi. 10.1038/ncb2581
By:
- van Es, Johan H.;
- Sato, Toshiro;
- van de Wetering, Marc;
- Lyubimova, Anna;
- Yee Nee, Annie Ng;
- Gregorieff, Alex;
- Sasaki, Nobuo;
- Zeinstra, Laura;
- van den Born, Maaike;
- Korving, Jeroen;
- Martens, Anton C. M.;
- Barker, Nick;
- van Oudenaarden, Alexander;
- Clevers, Hans
Publication type:
Article
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.
Published in:
Nature Cell Biology, 2012, v. 14, n. 4, p. 401, doi. 10.1038/ncb2464
By:
- Wong, Vivian W. Y.;
- Stange, Daniel E.;
- Page, Mahalia E.;
- Buczacki, Simon;
- Wabik, Agnieszka;
- Itami, Satoshi;
- van de Wetering, Marc;
- Poulsom, Richard;
- Wright, Nicholas A.;
- Trotter, Matthew W. B.;
- Watt, Fiona M.;
- Winton, Doug J.;
- Clevers, Hans;
- Jensen, Kim B.
Publication type:
Article
Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.
Published in:
Nature Communications, 2014, v. 5, n. 12, p. 5728, doi. 10.1038/ncomms6728
By:
- Simmini, Salvatore;
- Bialecka, Monika;
- Huch, Meritxell;
- Kester, Lennart;
- van de Wetering, Marc;
- Sato, Toshiro;
- Beck, Felix;
- van Oudenaarden, Alexander;
- Clevers, Hans;
- Deschamps, Jacqueline
Publication type:
Article
DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.
Published in:
Genome Biology, 2013, v. 14, n. 5, p. 1, doi. 10.1186/gb-2013-14-5-r50
By:
- Kaaij, Lucas T. J.;
- van de Wetering, Marc;
- Fang, Fang;
- Decato, Benjamin;
- Molaro, Antoine;
- van de Werken, Harmen J. G.;
- van Es, Johan H.;
- Schuijers, Jurian;
- de Wit, Elzo;
- de Laat, Wouter;
- Hannon, Gregory J.;
- Clevers, Hans C.;
- Smith, Andrew D.;
- Ketting, René F.
Publication type:
Article
Sequential cancer mutations in cultured human intestinal stem cells.
Published in:
Nature, 2015, v. 521, n. 7550, p. 43, doi. 10.1038/nature14415
By:
- Drost, Jarno;
- van Jaarsveld, Richard H.;
- Ponsioen, Bas;
- Zimberlin, Cheryl;
- van Boxtel, Ruben;
- Buijs, Arjan;
- Sachs, Norman;
- Overmeer, René M.;
- Offerhaus, G. Johan;
- Begthel, Harry;
- Korving, Jeroen;
- van de Wetering, Marc;
- Schwank, Gerald;
- Logtenberg, Meike;
- Cuppen, Edwin;
- Snippert, Hugo J.;
- Medema, Jan Paul;
- Kops, Geert J. P. L.;
- Clevers, Hans
Publication type:
Article
Genome sequencing of normal cells reveals developmental lineages and mutational processes.
Published in:
Nature, 2014, v. 513, n. 7518, p. 422, doi. 10.1038/nature13448
By:
- Behjati, Sam;
- Huch, Meritxell;
- van Boxtel, Ruben;
- Karthaus, Wouter;
- Wedge, David C.;
- Martincorena, Iñigo;
- Petljak, Mia;
- Alexandrov, Ludmil B.;
- Gundem, Gunes;
- Tarpey, Patrick S.;
- Roerink, Sophie;
- Maddison, Mark;
- Mudie, Laura;
- Robinson, Ben;
- Campbell, Peter;
- Stratton, Michael R.;
- Tamuri, Asif U.;
- Goldman, Nick;
- Blokker, Joyce;
- van de Wetering, Marc
Publication type:
Article
In vitro expansion of single Lgr5<sup>+</sup> liver stem cells induced by Wnt-driven regeneration.
Published in:
Nature, 2013, v. 494, n. 7436, p. 247, doi. 10.1038/nature11826
By:
- Huch, Meritxell;
- Dorrell, Craig;
- Boj, Sylvia F.;
- van Es, Johan H.;
- Li, Vivian S. W.;
- van de Wetering, Marc;
- Sato, Toshiro;
- Hamer, Karien;
- Sasaki, Nobuo;
- Finegold, Milton J.;
- Haft, Annelise;
- Vries, Robert G.;
- Grompe, Markus;
- Clevers, Hans
Publication type:
Article
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.
Published in:
Nature, 2012, v. 488, n. 7413, p. 665, doi. 10.1038/nature11308
By:
- Koo, Bon-Kyoung;
- Spit, Maureen;
- Jordens, Ingrid;
- Low, Teck Y.;
- Stange, Daniel E.;
- van de Wetering, Marc;
- van Es, Johan H.;
- Mohammed, Shabaz;
- Heck, Albert J. R.;
- Maurice, Madelon M.;
- Clevers, Hans
Publication type:
Article
Destabilization of beta catenin by mutations in presenilin-1 potentiates neuronal apoptosis.
Published in:
Nature, 1998, v. 395, n. 6703, p. 698, doi. 10.1038/27208
By:
- Zhang, Zhuohua;
- Hartmann, Henrike;
- Viet Minh Do;
- Abramowski, Dorothee;
- Sturchler-Pierrat, Christine;
- Staufenbiel, Matthias;
- Sommer, Bernd;
- van de Wetering, Marc;
- Clevers, Hans;
- Saftig, Paul;
- De Strooper, Bart;
- Xi He;
- Yankner, Bruce A.
Publication type:
Article

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