Works matching DE "PRESENILINS"
Results: 858
3D Blockage Mapping for Identifying Familial Point Mutations in Single Amyloid‐β Peptides with a Nanopore.
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- Angewandte Chemie, 2022, v. 134, n. 44, p. 1, doi. 10.1002/ange.202209970
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- Article
Protein Flexibility and Dissociation Pathway Differentiation Can Explain Onset of Resistance Mutations in Kinases*.
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- Angewandte Chemie, 2022, v. 134, n. 28, p. 1, doi. 10.1002/ange.202200983
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- Article
From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein‐Templated Synthesis.
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- Angewandte Chemie, 2021, v. 133, n. 35, p. 19493, doi. 10.1002/ange.202106295
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- Article
Kanuka bush leaves for Alzheimer’s disease: Improved inhibition of β-secretase enzyme, antioxidant capacity and yield of extracts by ultrasound assisted extraction.
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- Food & Bioproducts Processing: Transactions of the Institution of Chemical Engineers Part C, 2021, v. 128, p. 109, doi. 10.1016/j.fbp.2021.04.018
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- Article
Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin.
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- Experimental Brain Research, 2012, v. 217, n. 3/4, p. 331, doi. 10.1007/s00221-011-2952-0
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- Article
Alterations in presenilin 1 processing by amyloid-β peptide in the rat retina.
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- Experimental Brain Research, 2007, v. 181, n. 1, p. 69, doi. 10.1007/s00221-007-0904-5
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- Article
Characterization of β-secretase inhibitory extracts from sea cucumber (Stichopus japonicus) hydrolysis with their cellular level mechanism in SH-SY5Y cells.
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- European Food Research & Technology, 2021, v. 247, n. 8, p. 2039, doi. 10.1007/s00217-021-03770-6
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- Article
Accelerated acquisition of permeability barrier function in the skin of presenilin-1-deficient embryos.
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- Archives of Dermatological Research, 2007, v. 298, n. 7, p. 339, doi. 10.1007/s00403-006-0696-7
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- Article
邻苯二甲酸二乙基己酯与双酚 A 联合染毒对小鼠学习记忆障碍及淀粉样前体蛋白酶解通路的影响
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- Asian Journals of Ecotoxicology, 2022, v. 17, n. 1, p. 255, doi. 10.7524/AJE.1673-5897.20210509001
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- Article
miRDRN--miRNA disease regulatory network: a tool for exploring disease and tissue-specific microRNA regulatory networks.
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- PeerJ, 2019, p. 1, doi. 10.7717/peerj.7309
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- Article
Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2020, v. 35, n. 1, p. 1944, doi. 10.1080/14756366.2020.1835882
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- Article
SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy.
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- Cell Discovery, 2022, v. 8, n. 1, p. 1, doi. 10.1038/s41421-022-00458-3
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- Article
Atypical presentation of a novel Presenilin 1 R377W mutation: sporadic, late-onset Alzheimer disease with epilepsy and frontotemporal atrophy.
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- Neurological Sciences, 2012, v. 33, n. 2, p. 375, doi. 10.1007/s10072-011-0714-1
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- Article
Presenilin-2 gene mutation presenting as Lewy Body dementia?
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- 2011
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- Letter
姜黄素对小鼠海马 Aβ 生成酶和降解酶的影响.
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- Journal of Beijing University of Traditional Chinese Medicine, 2016, v. 39, n. 3, p. 230, doi. 10.3969/j.issn.1006-2157.2016.03.011
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- Article
Cognitive Deficits in Familial Alzheimer’s Disease Associated with M239V Mutation of Presenilin 2.
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- Dementia & Geriatric Cognitive Disorders, 2006, v. 22, n. 3, p. 238, doi. 10.1159/000094972
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- Article
Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity.
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- Pathology International, 2002, v. 52, n. 9, p. 551, doi. 10.1046/j.1440-1827.2002.01398.x
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- Article
Mint/X11 PDZ domains from non-bilaterian animals recognize and bind Ca<sub>V</sub>2 calcium channel C-termini in vitro.
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- Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-70652-8
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- Article
Bacillaceae serine proteases and Streptomyces epsilon-poly-l-lysine synergistically inactivate Caliciviridae by inhibiting RNA genome release.
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- Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-65963-9
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- Article
Protease-Sensitive and -Resistant Forms of Human and Murine Alpha-Synucleins in Distinct Brain Regions of Transgenic Mice (M83) Expressing the Human Mutated A53T Protein.
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- Biomolecules (2218-273X), 2023, v. 13, n. 12, p. 1788, doi. 10.3390/biom13121788
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- Article
The Role of Cholesterol in Amyloidogenic Substrate Binding to the γ-Secretase Complex.
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- Biomolecules (2218-273X), 2021, v. 11, n. 7, p. 935, doi. 10.3390/biom11070935
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- Article
Glycyl-L-Prolyl-L-Glutamate Pseudotripeptides for Treatment of Alzheimer's Disease.
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- Biomolecules (2218-273X), 2021, v. 11, n. 1, p. 126, doi. 10.3390/biom11010126
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- Article
Trypanosoma cruzi Presenilin-Like Transmembrane Aspartyl Protease: Characterization and Cellular Localization.
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- Biomolecules (2218-273X), 2020, v. 10, n. 11, p. 1564, doi. 10.3390/biom10111564
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- Article
Butyrylcholinesterase Protein Ends in the Pathogenesis of Alzheimer's Disease—Could BCHE Genotyping Be Helpful in Alzheimer's Therapy?
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- Biomolecules (2218-273X), 2019, v. 9, n. 10, p. 592, doi. 10.3390/biom9100592
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- Article
Yizhiqingxin Formula Alleviates Cognitive Deficits and Enhances Autophagy via mTOR Signaling Pathway Modulation in Early Onset Alzheimer's Disease Mice.
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- Frontiers in Pharmacology, 2019, p. 1, doi. 10.3389/fphar.2019.01041
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- Article
No endogenous Aβ production in presenilin-deficient fibroblasts.
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- Nature Cell Biology, 2002, v. 4, n. 7, p. E164, doi. 10.1038/ncb0702-e164a
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- Article
Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.
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- Nature Cell Biology, 2001, v. 3, n. 12, p. 1129, doi. 10.1038/ncb1201-1129
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- Article
Endogenous β-amyloid production in presenilin-deficient embryonic mouse fibroblasts.
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- Nature Cell Biology, 2001, v. 3, n. 11, p. 1030, doi. 10.1038/ncb1101-1030
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- Article
Presenilins and the intramembrane proteolysis of proteins: facts and fiction.
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- Nature Cell Biology, 2001, v. 3, n. 10, p. E221, doi. 10.1038/ncb1001-e221
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- Article
Presenilin and the UPR.
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- Nature Cell Biology, 2001, v. 3, n. 5, p. E104, doi. 10.1038/35074613
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- Article
Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.
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- Nature Cell Biology, 2000, v. 2, n. 12, p. 863, doi. 10.1038/35046500
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- Article
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases.
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- Nature Cell Biology, 2000, v. 2, n. 11, p. 848, doi. 10.1038/35041097
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- Article
Total inactivation of γ?secretase activity in presenilin-deficient embryonic stem cells.
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- Nature Cell Biology, 2000, v. 2, n. 7, p. 461, doi. 10.1038/35017105
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- Article
Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch.
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- Nature Cell Biology, 2000, v. 2, n. 4, p. 205, doi. 10.1038/35008626
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- Article
Presenilin mutants subvert chaperone function.
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- Nature Cell Biology, 2000, v. 2, n. 2, p. E21, doi. 10.1038/35000090
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- Article
Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response.
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- Nature Cell Biology, 1999, v. 1, n. 8, p. 479, doi. 10.1038/70265
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- Article
The case against presenilin-1.
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- Nature Cell Biology, 1999, v. 1, n. 7, p. E181, doi. 10.1038/15619
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- Article
Limited Substrate Specificity of PS/γ-Secretase Is Supported by Novel Multiplexed FRET Analysis in Live Cells.
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- Biosensors (2079-6374), 2021, v. 11, n. 6, p. 169, doi. 10.3390/bios11060169
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- Article
Down-regulation of insulin-degrading enzyme by presenilin 1 V97L mutant potentially underlies increased levels of amyloid beta 42.
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- European Journal of Neuroscience, 2008, v. 27, n. 9, p. 2425, doi. 10.1111/j.1460-9568.2008.06207.x
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- Article
Synapsin 1 promotes Aβ generation via BACE1 modulation.
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- PLoS ONE, 2019, v. 14, n. 12, p. 1, doi. 10.1371/journal.pone.0226368
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- Article
Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation.
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- Frontiers in Molecular Neuroscience, 2017, p. 1, doi. 10.3389/fnmol.2017.00291
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- Article
Proteínas claro de luna o multitarea.
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- Producción Más Limpia, 2022, v. 17, n. 1, p. 4, doi. 10.22507/pml.v17n1e
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- Article
Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues.
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- Nature Biotechnology, 2004, v. 22, n. 6, p. 724, doi. 10.1038/nbt969
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- Article
Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein
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- FEBS Letters, 2004, v. 557, n. 1-3, p. 185, doi. 10.1016/S0014-5793(03)01489-3
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- Article
Oligomerization of human presenilin-1 fragments
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- FEBS Letters, 2003, v. 550, n. 1-3, p. 30, doi. 10.1016/S0014-5793(03)00813-5
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- Article
Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments
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- FEBS Letters, 2002, v. 520, n. 1-3, p. 117, doi. 10.1016/S0014-5793(02)02802-8
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- Article
γ-Secretase: a multifaceted regulator of angiogenesis.
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- Journal of Cellular & Molecular Medicine, 2008, v. 12, n. 3, p. 781, doi. 10.1111/j.1582-4934.2008.00274.x
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- Article
Presenilin-dependent regulated intramembrane proteolysis and γ-secretase activity.
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- Cellular & Molecular Life Sciences, 2009, v. 66, n. 9, p. 1534, doi. 10.1007/s00018-009-8435-9
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- Article
Substrate specificity of γ-secretase and other intramembrane proteases.
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- Cellular & Molecular Life Sciences, 2008, v. 65, n. 9, p. 1311, doi. 10.1007/s00018-008-7462-2
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- Article
Glycogen synthase kinase 3β and Alzheimer’s disease: pathophysiological and therapeutic significance.
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- Cellular & Molecular Life Sciences, 2006, v. 63, n. 11, p. 1226, doi. 10.1007/s00018-005-5597-y
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- Article