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Environmental variables and genome-environment interactions predicting IBD diagnosis in large UK cohort.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-13222-0
By:
- Yang, Alan Z.;
- Jostins-Dean, Luke
Publication type:
Article
Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32718-x
By:
- Zhou, Dingxi;
- Borsa, Mariana;
- Puleston, Daniel J.;
- Zellner, Susanne;
- Capera, Jesusa;
- Sanderson, Sharon;
- Schifferer, Martina;
- Hester, Svenja S.;
- Ge, Xin;
- Fischer, Roman;
- Jostins, Luke;
- Behrends, Christian;
- Alsaleh, Ghada;
- Simon, Anna Katharina
Publication type:
Article
Reverse engineering a gene network using an asynchronous parallel evolution strategy.
Published in:
BMC Systems Biology, 2010, v. 4, p. 17, doi. 10.1186/1752-0509-4-17
By:
- Jostins, Luke;
- Jaeger, Johannes
Publication type:
Article
Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27038-5
By:
- Ryzhakov, Grigory;
- Almuttaqi, Hannah;
- Corbin, Alastair L.;
- Berthold, Dorothée L.;
- Khoyratty, Tariq;
- Eames, Hayley L.;
- Bullers, Samuel;
- Pearson, Claire;
- Ai, Zhichao;
- Zec, Kristina;
- Bonham, Sarah;
- Fischer, Roman;
- Jostins-Dean, Luke;
- Travis, Simon P. L.;
- Kessler, Benedikt M.;
- Udalova, Irina A.
Publication type:
Article
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
Published in:
Nature Genetics, 2015, v. 47, n. 9, p. 979, doi. 10.1038/ng.3359
By:
- Shah, Tejas;
- Barrett, Jeffrey C;
- Daryani, Naser E;
- B K, Thelma;
- Orchard, Timothy R;
- Ng, Siew C;
- Weersma, Rinse K;
- Jostins, Luke;
- Vahedi, Homayon;
- Juyal, Ramesh C;
- Midha, Vandana;
- Ripke, Stephan;
- Daly, Mark J;
- Alberts, Rudi;
- Poustchi, Hossein;
- Kim, Won Ho;
- Kubo, Michiaki;
- Juyal, Garima;
- Newman, William G;
- Franke, Andre
Publication type:
Article
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
Published in:
Nature Genetics, 2015, v. 47, n. 2, p. 172, doi. 10.1038/ng.3176
By:
- Boucher, Gabrielle;
- Ellinghaus, Eva;
- Franke, Andre;
- Daly, Mark J;
- Goyette, Philippe;
- Barrett, Jeffrey C;
- Schumm, L Philip;
- Carrington, Mary N;
- Karlsen, Tom H;
- Ripke, Stephan;
- Oksenberg, Jorge R;
- Leslie, Stephen;
- McGovern, Dermot P B;
- Rioux, John D;
- Mallon, Dermot;
- Kosmoliaptsis, Vasilis;
- Thomsen, Ingo;
- Jostins, Luke;
- Huang, Hailiang;
- Gusareva, Elena S
Publication type:
Article
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
Published in:
Nature Genetics, 2012, v. 44, n. 10, p. 1137, doi. 10.1038/ng.2395
By:
- Liu, Jimmy Z;
- Almarri, Mohamed A;
- Gaffney, Daniel J;
- Mells, George F;
- Jostins, Luke;
- Cordell, Heather J;
- Ducker, Samantha J;
- Day, Darren B;
- Heneghan, Michael A;
- Neuberger, James M;
- Donaldson, Peter T;
- Bathgate, Andrew J;
- Burroughs, Andrew;
- Davies, Mervyn H;
- Jones, David E;
- Alexander, Graeme J;
- Barrett, Jeffrey C;
- Sandford, Richard N;
- Anderson, Carl A
Publication type:
Article
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
Published in:
Nature Genetics, 2010, v. 42, n. 12, p. 1118, doi. 10.1038/ng.717
By:
- Franke, Andre;
- McGovern, Dermot P. B.;
- Barrett, Jeffrey C.;
- Kai Wang;
- Radford-Smith, Graham L.;
- Ahmad, Tariq;
- Lees, Charlie W.;
- Balschun, Tobias;
- Lee, James;
- Roberts, Rebecca;
- Anderson, Carl A.;
- Bis, Joshua C.;
- Bumpstead, Suzanne;
- Ellinghaus, David;
- Festen, Eleonora M.;
- Georges, Michel;
- Green, Todd;
- Haritunians, Talin;
- Jostins, Luke;
- Latiano, Anna
Publication type:
Article
Using Genetic Prediction from Known Complex Disease Loci to Guide the Design of Next-Generation Sequencing Experiments.
Published in:
PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0076328
By:
- Jostins, Luke;
- Levine, Adam P.;
- Barrett, Jeffrey C.
Publication type:
Article
Imputation of low-frequency variants using the HapMap3 benefits from large, diverse reference sets.
Published in:
European Journal of Human Genetics, 2011, v. 19, n. 6, p. 662, doi. 10.1038/ejhg.2011.10
By:
- Jostins, Luke;
- Morley, Katherine I;
- Barrett, Jeffrey C
Publication type:
Article
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.
Published in:
Science Translational Medicine, 2016, v. 8, n. 363, p. 1, doi. 10.1126/scitranslmed.aag1974
By:
- Dendrou, Calliope A.;
- Cortes, Adrian;
- Shipman, Lydia;
- Evans, Hayley G.;
- Attfield, Kathrine E.;
- Jostins, Luke;
- Barber, Thomas;
- Kaur, Gurman;
- Kuttikkatte, Subita Balaram;
- Leach, Oliver A.;
- Desel, Christiane;
- Faergeman, Soren L.;
- Cheeseman, Jane;
- Neville, Matt J.;
- Sawcer, Stephen;
- Compston, Alastair;
- Johnson, Adam R.;
- Everett, Christine;
- Bell, John I.;
- Karpe, Fredrik
Publication type:
Article
Dispatches from the functional phase of genome biology.
Published in:
Genome Biology, 2012, v. 13, n. 6, p. 316, doi. 10.1186/gb4025
By:
- Jostins, Luke
Publication type:
Article
Genetic risk prediction in complex disease.
Published in:
Human Molecular Genetics, 2011, v. 20, n. R2, p. R182, doi. 10.1093/hmg/ddr378
By:
- Jostins, Luke;
- Barrett, Jeffrey C.
Publication type:
Article
Negligible impact of rare autoimmune-locus coding-region variants on missing heritability.
Published in:
Nature, 2013, v. 498, n. 7453, p. 232, doi. 10.1038/nature12170
By:
- Hunt, Karen A.;
- Mistry, Vanisha;
- Bockett, Nicholas A.;
- Ahmad, Tariq;
- Ban, Maria;
- Barker, Jonathan N.;
- Barrett, Jeffrey C.;
- Blackburn, Hannah;
- Brand, Oliver;
- Burren, Oliver;
- Capon, Francesca;
- Compston, Alastair;
- Gough, Stephen C. L.;
- Jostins, Luke;
- Kong, Yong;
- Lee, James C.;
- Lek, Monkol;
- MacArthur, Daniel G.;
- Mansfield, John C.;
- Mathew, Christopher G.
Publication type:
Article
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Published in:
Nature, 2012, v. 491, n. 7422, p. 119, doi. 10.1038/nature11582
By:
- Jostins, Luke;
- Ripke, Stephan;
- Weersma, Rinse K.;
- Duerr, Richard H.;
- McGovern, Dermot P.;
- Hui, Ken Y.;
- Lee, James C.;
- Philip Schumm, L.;
- Sharma, Yashoda;
- Anderson, Carl A.;
- Essers, Jonah;
- Mitrovic, Mitja;
- Ning, Kaida;
- Cleynen, Isabelle;
- Theatre, Emilie;
- Spain, Sarah L.;
- Raychaudhuri, Soumya;
- Goyette, Philippe;
- Wei, Zhi;
- Abraham, Clara
Publication type:
Article
Imputation-Based Meta-Analysis of Severe Malaria in Three African Populations
Published in:
PLoS Genetics, 2013, v. 9, n. 5, p. 1, doi. 10.1371/journal.pgen.1003509
By:
- Band, Gavin;
- Le, Quang Si;
- Jostins, Luke;
- Pirinen, Matti;
- Kivinen, Katja;
- Jallow, Muminatou;
- Sisay-Joof, Fatoumatta;
- Bojang, Kalifa;
- Pinder, Margaret;
- Sirugo, Giorgio;
- Conway, David J.;
- Nyirongo, Vysaul;
- Kachala, David;
- Molyneux, Malcolm;
- Taylor, Terrie;
- Ndila, Carolyne;
- Peshu, Norbert;
- Marsh, Kevin;
- Williams, Thomas N.;
- Alcock, Daniel
Publication type:
Article
Bayesian meta‐analysis across genome‐wide association studies of diverse phenotypes.
Published in:
Genetic Epidemiology, 2019, v. 43, n. 5, p. 532, doi. 10.1002/gepi.22202
By:
- Trochet, Holly;
- Pirinen, Matti;
- Band, Gavin;
- Jostins, Luke;
- McVean, Gilean;
- Spencer, Chris C. A.
Publication type:
Article
Trinculo: Bayesian and frequentist multinomial logistic regression for genome-wide association studies of multi-category phenotypes.
Published in:
Bioinformatics, 2016, v. 32, n. 12, p. 1898, doi. 10.1093/bioinformatics/btw075
By:
- Jostins, Luke;
- McVean, Gilean
Publication type:
Article
Microindel detection in short-read sequence data.
Published in:
Bioinformatics, 2010, v. 26, n. 6, p. 722, doi. 10.1093/bioinformatics/btq027
By:
- Krawitz, Peter;
- Rödelsperger, Christian;
- Jäger, Marten;
- Jostins, Luke;
- Bauer, Sebastian;
- Robinson, Peter N.
Publication type:
Article

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