Found: 25

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  • Identification of siRNA delivery enhancers by a chemical library screen.

    Published in:
    Nucleic Acids Research, 2015, v. 43, n. 16, p. 7984, doi. 10.1093/nar/gkv762
    By:
    • Gilleron, Jerome;
    • Paramasivam, Prasath;
    • Zeigerer, Anja;
    • Querbes, William;
    • Marsico, Giovanni;
    • Andree, Cordula;
    • Seifert, Sarah;
    • Amaya, Pablo;
    • Stöter, Martin;
    • Koteliansky, Victor;
    • Waldmann, Herbert;
    • Fitzgerald, Kevin;
    • Kalaidzidis, Yannis;
    • Akinc, Akin;
    • Maier, Martin A.;
    • Manoharan, Muthiah;
    • Bickle, Marc;
    • Zerial, Marino
    Publication type:
    Article

  • In vivo quantification of formulated and chemically modified small interfering RNA by heating-in-Triton quantitative reverse transcription polymerase chain reaction (HIT qRT-PCR).

    Published in:
    Silence, 2010, v. 1, n. 1, p. 1, doi. 10.1186/1758-907X-1-16
    By:
    • Landesman, Yosef;
    • Svrzikapa, Nenad;
    • Cognetta, III., Armand;
    • Xuemei Zhang;
    • Bettencourt, Brian R.;
    • Kuchimanchi, Satya;
    • Dufault, Keri;
    • Shaikh, Sarfraz;
    • Gioia, Maple;
    • Akinc, Akin;
    • Hutabarat, Renta;
    • Meyers, Rachel
    Publication type:
    Article

  • Reversal of siRNA-mediated gene silencing in vivo.

    Published in:
    Nature Biotechnology, 2018, v. 36, n. 6, p. 509, doi. 10.1038/nbt.4136
    By:
    • Zlatev, Ivan;
    • Castoreno, Adam;
    • Brown, Christopher R;
    • Qin, June;
    • Waldron, Scott;
    • Schlegel, Mark K;
    • Degaonkar, Rohan;
    • Shulga-Morskaya, Svetlana;
    • Xu, Huilei;
    • Gupta, Swati;
    • Matsuda, Shigeo;
    • Akinc, Akin;
    • Rajeev, Kallanthottathil G;
    • Manoharan, Muthiah;
    • Maier, Martin A;
    • Jadhav, Vasant
    Publication type:
    Article

  • Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape.

    Published in:
    Nature Biotechnology, 2013, v. 31, n. 7, p. 638, doi. 10.1038/nbt.2612
    By:
    • Gilleron, Jerome;
    • Querbes, William;
    • Zeigerer, Anja;
    • Borodovsky, Anna;
    • Marsico, Giovanni;
    • Schubert, Undine;
    • Manygoats, Kevin;
    • Seifert, Sarah;
    • Andree, Cordula;
    • Stöter, Martin;
    • Epstein-Barash, Hila;
    • Zhang, Ligang;
    • Koteliansky, Victor;
    • Fitzgerald, Kevin;
    • Fava, Eugenio;
    • Bickle, Marc;
    • Kalaidzidis, Yannis;
    • Akinc, Akin;
    • Maier, Martin;
    • Zerial, Marino
    Publication type:
    Article

  • Rational design of cationic lipids for siRNA delivery.

    Published in:
    Nature Biotechnology, 2010, v. 28, n. 2, p. 172, doi. 10.1038/nbt.1602
    By:
    • Semple, Sean C.;
    • Akinc, Akin;
    • Chen, Jianxin;
    • Sandhu, Ammen P.;
    • Mui, Barbara L.;
    • Cho, Connie K.;
    • Sah, Dinah W. Y.;
    • Stebbing, Derrick;
    • Crosley, Erin J.;
    • Yaworski, Ed;
    • Hafez, Ismail M.;
    • Dorkin, J. Robert;
    • Qin, June;
    • Lam, Kieu;
    • Rajeev, Kallanthottathil G.;
    • Wong, Kim F.;
    • Jeffs, Lloyd B.;
    • Nechev, Lubomir;
    • Eisenhardt, Merete L.;
    • Jayaraman, Muthusamy
    Publication type:
    Article

  • A combinatorial library of lipid-like materials for delivery of RNAi therapeutics.

    Published in:
    Nature Biotechnology, 2008, v. 26, n. 5, p. 561, doi. 10.1038/nbt1402
    By:
    • Akinc, Akin;
    • Zumbuehl, Andreas;
    • Goldberg, Michael;
    • Leshchiner, Elizaveta S;
    • Busini, Valentina;
    • Hossain, Naushad;
    • Bacallado, Sergio A;
    • Nguyen, David N;
    • Fuller, Jason;
    • Alvarez, Rene;
    • Borodovsky, Anna;
    • Borland, Todd;
    • Constien, Rainer;
    • de Fougerolles, Antonin;
    • Dorkin, J Robert;
    • Narayanannair Jayaprakash, K;
    • Jayaraman, Muthusamy;
    • John, Matthias;
    • Koteliansky, Victor;
    • Manoharan, Muthiah
    Publication type:
    Article

  • Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo.

    Published in:
    Angewandte Chemie, 2012, v. 124, n. 34, p. 8657, doi. 10.1002/ange.201203263
    By:
    • Jayaraman, Muthusamy;
    • Ansell, Steven M.;
    • Mui, Barbara L.;
    • Tam, Ying K.;
    • Chen, Jianxin;
    • Du, Xinyao;
    • Butler, David;
    • Eltepu, Laxman;
    • Matsuda, Shigeo;
    • Narayanannair, Jayaprakash K.;
    • Rajeev, Kallanthottathil G.;
    • Hafez, Ismail M.;
    • Akinc, Akin;
    • Maier, Martin A.;
    • Tracy, Mark A.;
    • Cullis, Pieter R.;
    • Madden, Thomas D.;
    • Manoharan, Muthiah;
    • Hope, Michael J.
    Publication type:
    Article

  • Unique Gene-Silencing and Structural Properties of 2′-Fluoro-Modified siRNAs.

    Published in:
    Angewandte Chemie, 2011, v. 123, n. 10, p. 2332, doi. 10.1002/ange.201006519
    By:
    • Manoharan, Muthiah;
    • Akinc, Akin;
    • Pandey, Rajendra K.;
    • Qin, June;
    • Hadwiger, Philipp;
    • John, Matthias;
    • Mills, Kathy;
    • Charisse, Klaus;
    • Maier, Martin A.;
    • Nechev, Lubomir;
    • Greene, Emily M.;
    • Pallan, Pradeep S.;
    • Rozners, Eriks;
    • Rajeev, Kallanthottathil G.;
    • Egli, Martin
    Publication type:
    Article

  • Measuring the pH environment of DNA delivered using nonviral vectors: Implications for lysosomal trafficking.

    Published in:
    Biotechnology & Bioengineering, 2002, v. 78, n. 5, p. 503, doi. 10.1002/bit.20215
    By:
    • Akinc, Akin;
    • Langer, Robert
    Publication type:
    Article

  • The Roles of Individual Mammalian Argonautes in RNA Interference <i>In Vivo</i>.

    Published in:
    PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0101749
    By:
    • Ruda, Vera M.;
    • Chandwani, Rohit;
    • Sehgal, Alfica;
    • Bogorad, Roman L.;
    • Akinc, Akin;
    • Charisse, Klaus;
    • Tarakhovsky, Alexander;
    • Novobrantseva, Tatiana I.;
    • Koteliansky, Victor
    Publication type:
    Article

  • Inside Cover: 5′-( E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates (ChemBioChem 11/2016).

    Published in:
    ChemBioChem, 2016, v. 17, n. 11, p. 970, doi. 10.1002/cbic.201600278
    By:
    • Parmar, Rubina;
    • Willoughby, Jennifer L. S.;
    • Liu, Jingxuan;
    • Foster, Donald J.;
    • Brigham, Benjamin;
    • Theile, Christopher S.;
    • Charisse, Klaus;
    • Akinc, Akin;
    • Guidry, Erin;
    • Pei, Yi;
    • Strapps, Walter;
    • Cancilla, Mark;
    • Stanton, Matthew G.;
    • Rajeev, Kallanthottathil G.;
    • Sepp‐Lorenzino, Laura;
    • Manoharan, Muthiah;
    • Meyers, Rachel;
    • Maier, Martin A.;
    • Jadhav, Vasant
    Publication type:
    Article

  • 5′-( E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.

    Published in:
    ChemBioChem, 2016, v. 17, n. 11, p. 985, doi. 10.1002/cbic.201600130
    By:
    • Parmar, Rubina;
    • Willoughby, Jennifer L. S.;
    • Liu, Jingxuan;
    • Foster, Donald J.;
    • Brigham, Benjamin;
    • Theile, Christopher S.;
    • Charisse, Klaus;
    • Akinc, Akin;
    • Guidry, Erin;
    • Pei, Yi;
    • Strapps, Walter;
    • Cancilla, Mark;
    • Stanton, Matthew G.;
    • Rajeev, Kallanthottathil G.;
    • Sepp‐Lorenzino, Laura;
    • Manoharan, Muthiah;
    • Meyers, Rachel;
    • Maier, Martin A.;
    • Jadhav, Vasant
    Publication type:
    Article

  • MicroRNAs 103 and 107 regulate insulin sensitivity.

    Published in:
    Nature, 2011, v. 474, n. 7353, p. 649, doi. 10.1038/nature10112
    By:
    • Trajkovski, Mirko;
    • Hausser, Jean;
    • Soutschek, Jürgen;
    • Bhat, Bal;
    • Akin, Akinc;
    • Zavolan, Mihaela;
    • Heim, Markus H.;
    • Stoffel, Markus
    Publication type:
    Article

  • Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway.

    Published in:
    Nature, 2007, v. 449, n. 7163, p. 745, doi. 10.1038/nature06179
    By:
    • John, Matthias;
    • Constien, Rainer;
    • Akinc, Akin;
    • Goldberg, Michael;
    • Young-Ah Moon;
    • Spranger, Martina;
    • Hadwiger, Philipp;
    • Soutschek, Jürgen;
    • Vornlocher, Hans-Peter;
    • Manoharan, Muthiah;
    • Stoffel, Markus;
    • Langer, Robert;
    • Anderson, Daniel G.;
    • Horton, Jay D.;
    • Koteliansky, Victor;
    • Bumcrot, David
    Publication type:
    Article

  • RNAi-mediated gene silencing in non-human primates.

    Published in:
    2006
    By:
    • Zimmermann, Tracy S.;
    • Lee, Amy C. H.;
    • Akinc, Akin;
    • Bramlage, Birgit;
    • Bumcrot, David;
    • Fedoruk, Matthew N.;
    • Harborth, Jens;
    • Heyes, James A.;
    • Jeffs, Lloyd B.;
    • John, Matthias;
    • Judge, Adam D.;
    • Kieu Lam;
    • McClintock, Kevin;
    • Nechev, Lubomir V.;
    • Palmer, Lorne R.;
    • Racie, Timothy;
    • Röhl, Ingo;
    • Seiffert, Stephan;
    • Shanmugam, Sumi;
    • Sood, Vandana
    Publication type:
    Letter

  • CSF transthyretin neuroprotection in a mouse model of brain ischemia.

    Published in:
    Journal of Neurochemistry, 2010, v. 115, n. 6, p. 1434, doi. 10.1111/j.1471-4159.2010.07047.x
    By:
    • Santos, Sofia Duque;
    • Lambertsen, Kate Lykke;
    • Clausen, Bettina Hjelm;
    • Akinc, Akin;
    • Alvarez, Rene;
    • Finsen, Bente;
    • Saraiva, Maria João
    Publication type:
    Article

  • Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs.

    Published in:
    Nature, 2004, v. 432, n. 7014, p. 173, doi. 10.1038/nature03121
    By:
    • Soutschek, Jürgen;
    • Akinc, Akin;
    • Bramlage, Birgit;
    • Charisse, Klaus;
    • Constien, Rainer;
    • Donoghue, Mary;
    • Elbashir, Sayda;
    • Geick, Anke;
    • Hadwiger, Philipp;
    • Harborth, Jens;
    • John, Matthias;
    • Kesavan, Venkitasamy;
    • Lavine, Gary;
    • Pandey, Rajendra K.;
    • Racie, Timothy;
    • Rajeev, Kallanthottathil G.;
    • Röhl, Ingo;
    • Toudjarska, Ivanka;
    • Wang, Gang;
    • Wuschko, Silvio
    Publication type:
    Article

  • Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis.

    Published in:
    Journal of Gene Medicine, 2005, v. 7, n. 5, p. 657, doi. 10.1002/jgm.696
    By:
    • Akinc, Akin;
    • Thomas, Mini;
    • Klibanov, Alexander M.;
    • Langer, Robert
    Publication type:
    Article

  • Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells.

    Published in:
    Molecular Therapy, 2011, v. 19, n. 12, p. 2186, doi. 10.1038/mt.2011.190
    By:
    • Basha, Genc;
    • Novobrantseva, Tatiana I;
    • Rosin, Nicole;
    • Tam, Yuen Yi C;
    • Hafez, Ismail M;
    • Wong, Matthew K;
    • Sugo, Tsukasa;
    • Ruda, Vera M;
    • Qin, June;
    • Klebanov, Boris;
    • Ciufolini, Marco;
    • Akinc, Akin;
    • Tam, Ying K;
    • Hope, Michael J;
    • Cullis, Pieter R
    Publication type:
    Article

  • Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms.

    Published in:
    Molecular Therapy, 2010, v. 18, n. 7, p. 1357, doi. 10.1038/mt.2010.85
    By:
    • Akinc, Akin;
    • Querbes, William;
    • De, Soma;
    • Qin, June;
    • Frank-Kamenetsky, Maria;
    • Jayaprakash, K. Narayanannair;
    • Jayaraman, Muthusamy;
    • Rajeev, Kallanthottathil G;
    • Cantley, William L.;
    • Dorkin, J. Robert;
    • Butler, James S.;
    • Qin, LiuLiang;
    • Racie, Timothy;
    • Sprague, Andrew;
    • Fava, Eugenio;
    • Zeigerer, Anja;
    • Hope, Michael J.;
    • Zerial, Marino;
    • Sah, Dinah W. Y.;
    • Fitzgerald, Kevin
    Publication type:
    Article

  • Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver.

    Published in:
    Molecular Therapy, 2009, v. 17, n. 5, p. 872, doi. 10.1038/mt.2009.36
    By:
    • Akinc, Akin;
    • Goldberg, Michael;
    • Qin, June;
    • Dorkin, J. Robert;
    • Gamba-Vitalo, Christina;
    • Maier, Martin;
    • Jayaprakash, K. Narayanannair;
    • Jayaraman, Muthusamy;
    • Rajeev, Kallanthottathil G.;
    • Manoharan, Muthiah;
    • Koteliansky, Victor;
    • Röhl, Ingo;
    • Leshchiner, Elizaveta S.;
    • Langer, Robert;
    • Anderson, Daniel G.
    Publication type:
    Article

  • Assessing siRNA Pharmacodynamics in a Luciferase-expressing Mouse.

    Published in:
    Molecular Therapy, 2008, v. 16, n. 12, p. 1995, doi. 10.1038/mt.2008.187
    By:
    • Svensson, Robert U.;
    • Shey, Michael R.;
    • Ballas, Zuhair K.;
    • Dorkin, J. Robert;
    • Goldberg, Michael;
    • Akinc, Akin;
    • Langer, Robert;
    • Anderson, Daniel G.;
    • Bumcrot, David;
    • Henry, Michael D.
    Publication type:
    Article

  • Structure/property studies of polymeric gene delivery using a library of poly(β-amino esters)

    Published in:
    Molecular Therapy, 2005, v. 11, n. 3, p. 426, doi. 10.1016/j.ymthe.2004.11.015
    By:
    • Anderson, Daniel G.;
    • Akinc, Akin;
    • Hossain, Naushad;
    • Langer, Robert
    Publication type:
    Article

  • Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo.

    Published in:
    Angewandte Chemie International Edition, 2012, v. 51, n. 34, p. 8529, doi. 10.1002/anie.201203263
    By:
    • Jayaraman, Muthusamy;
    • Ansell, Steven M.;
    • Mui, Barbara L.;
    • Tam, Ying K.;
    • Chen, Jianxin;
    • Du, Xinyao;
    • Butler, David;
    • Eltepu, Laxman;
    • Matsuda, Shigeo;
    • Narayanannair, Jayaprakash K.;
    • Rajeev, Kallanthottathil G.;
    • Hafez, Ismail M.;
    • Akinc, Akin;
    • Maier, Martin A.;
    • Tracy, Mark A.;
    • Cullis, Pieter R.;
    • Madden, Thomas D.;
    • Manoharan, Muthiah;
    • Hope, Michael J.
    Publication type:
    Article

  • Unique Gene-Silencing and Structural Properties of 2′-Fluoro-Modified siRNAs.

    Published in:
    Angewandte Chemie International Edition, 2011, v. 50, n. 10, p. 2284, doi. 10.1002/anie.201006519
    By:
    • Manoharan, Muthiah;
    • Akinc, Akin;
    • Pandey, Rajendra K.;
    • Qin, June;
    • Hadwiger, Philipp;
    • John, Matthias;
    • Mills, Kathy;
    • Charisse, Klaus;
    • Maier, Martin A.;
    • Nechev, Lubomir;
    • Greene, Emily M.;
    • Pallan, Pradeep S.;
    • Rozners, Eriks;
    • Rajeev, Kallanthottathil G.;
    • Egli, Martin
    Publication type:
    Article