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Activation of apoptosis signaling eliminates CD34+ progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors.
Published in:
2012
By:
- Mak DH;
- Wang RY;
- Schober WD;
- Konopleva M;
- Cortes J;
- Kantarjian H;
- Andreeff M;
- Carter BZ;
- Mak, D H;
- Wang, R-Y;
- Schober, W D;
- Konopleva, M;
- Cortes, J;
- Kantarjian, H;
- Andreeff, M;
- Carter, B Z
Publication type:
journal article
Bisphosphonates as antimyeloma drugs.
Published in:
2012
By:
- Modi ND;
- Lentzsch S;
- Modi, N D;
- Lentzsch, S
Publication type:
journal article
Downregulation of MEIS1 impairs long-term expansion of CD34+ NPM1-mutated acute myeloid leukemia cells.
Published in:
2012
By:
- Woolthuis CM;
- Han L;
- Verkaik-Schakel RN;
- van Gosliga D;
- Kluin PM;
- Vellenga E;
- Schuringa JJ;
- Huls G
Publication type:
Journal Article
Notch is an essential upstream regulator of NF-[kappa]B and is relevant for survival of Hodgkin and Reed-Sternberg cells.
Published in:
2012
By:
- Schwarzer R;
- Dörken B;
- Jundt F
Publication type:
Journal Article
Development of acute myeloid leukemia with NPM1 mutation, in Ph-negative clone, during treatment of CML with imatinib.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 824, doi. 10.1038/leu.2011.280
By:
- Georgiou, G;
- Efthymiou, A;
- Vardounioti, I;
- Boutsikas, G;
- Angelopoulou, M K;
- Vassilakopoulos, T P;
- Kyrtsonis, M-C;
- Plata, E;
- Tofas, P;
- Bitsani, A;
- Bartzi, V;
- Pessach, I;
- Dimou, M;
- Panayiotidis, P
Publication type:
Article
Frequency of leukemic initiating cells does not depend on the xenotransplantation model used.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 858, doi. 10.1038/leu.2011.250
By:
- Vargaftig, J;
- Taussig, D C;
- Griessinger, E;
- Anjos-Afonso, F;
- Lister, T A;
- Cavenagh, J;
- Oakervee, H;
- Gribben, J;
- Bonnet, D
Publication type:
Article
An oncogenic role of miR-142-3p in human T-cell acute lymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor-α and cAMP/PKA pathways.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 769, doi. 10.1038/leu.2011.273
By:
- Lv, M;
- Zhang, X;
- Jia, H;
- Li, D;
- Zhang, B;
- Zhang, H;
- Hong, M;
- Jiang, T;
- Jiang, Q;
- Lu, J;
- Huang, X;
- Huang, B
Publication type:
Article
Involvement of the Syk-mTOR pathway in follicular lymphoma cell invasion and angiogenesis.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 795, doi. 10.1038/leu.2011.248
By:
- Fruchon, S;
- Kheirallah, S;
- Al Saati, T;
- Ysebaert, L;
- Laurent, C;
- Leseux, L;
- Fournié, J J;
- Laurent, G;
- Bezombes, C
Publication type:
Article
Activation of apoptosis signaling eliminates CD34<sup>+</sup> progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 788, doi. 10.1038/leu.2011.285
By:
- Mak, D H;
- Wang, R-Y;
- Schober, W D;
- Konopleva, M;
- Cortes, J;
- Kantarjian, H;
- Andreeff, M;
- Carter, B Z
Publication type:
Article
Phase 1b trial of atacicept, a recombinant protein binding BLyS and APRIL, in patients with chronic lymphocytic leukemia.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 841, doi. 10.1038/leu.2011.286
By:
- Kofler, D M;
- Gawlik, B B;
- Elter, T;
- Gianella-Borradori, A;
- Wendtner, C-M;
- Hallek, M
Publication type:
Article
Clinical laboratory markers of inflammation as determinants of chronic graft-versus-host disease activity and NIH global severity.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 633, doi. 10.1038/leu.2011.254
By:
- Grkovic, L;
- Baird, K;
- Steinberg, S M;
- Williams, K M;
- Pulanic, D;
- Cowen, E W;
- Mitchell, S A;
- Hakim, F T;
- Martires, K J;
- Avila, D N;
- Taylor, T N;
- Salit, R B;
- Rowley, S D;
- Zhang, D;
- Fowler, D H;
- Bishop, M R;
- Gress, R E;
- Pavletic, S Z
Publication type:
Article
Interest of the association azacitidine-lenalidomide as frontline therapy in high-risk myelodysplasia or acute myeloid leukemia with complex karyotype.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 822, doi. 10.1038/leu.2011.284
By:
- Scherman, E;
- Malak, S;
- Perot, C;
- Gorin, N C;
- Rubio, M T;
- Isnard, F
Publication type:
Article
IPSS-independent prognostic value of plasma CXCL10, IL-7 and IL-6 levels in myelodysplastic syndromes.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 693, doi. 10.1038/leu.2011.251
By:
- Pardanani, A;
- Finke, C;
- Lasho, T L;
- Al-Kali, A;
- Begna, K H;
- Hanson, C A;
- Tefferi, A
Publication type:
Article
Kinase domain mutations confer resistance to novel inhibitors targeting JAK2V617F in myeloproliferative neoplasms.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 708, doi. 10.1038/leu.2011.255
By:
- Deshpande, A;
- Reddy, M M;
- Schade, G O M;
- Ray, A;
- Chowdary, T K;
- Griffin, J D;
- Sattler, M
Publication type:
Article
Long-term transfusion independence in del(5q) MDS patients who discontinue lenalidomide.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 855, doi. 10.1038/leu.2011.268
By:
- Giagounidis, A A N;
- Kulasekararaj, A;
- Germing, U;
- Radkowski, R;
- Haase, S;
- Petersen, P;
- Göhring, G;
- Büsche, G;
- Aul, C;
- Mufti, G J;
- Platzbecker, U
Publication type:
Article
High concordance of subtypes of childhood acute lymphoblastic leukemia within families: lessons from sibships with multiple cases of leukemia.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 675, doi. 10.1038/leu.2011.274
By:
- Schmiegelow, K;
- Lausten Thomsen, U;
- Baruchel, A;
- Pacheco, C E;
- Pieters, Rob;
- Pombo-de-Oliveira, M S;
- Andersen, E W;
- Rostgaard, K;
- Hjalgrim, H;
- Pui, C-H
Publication type:
Article
Deletion of the tumor-suppressor gene NF1 occurs in 5% of myeloid malignancies and is accompanied by a mutation in the remaining allele in half of the cases.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 834, doi. 10.1038/leu.2011.296
By:
- Haferlach, C;
- Grossmann, V;
- Kohlmann, A;
- Schindela, S;
- Kern, W;
- Schnittger, S;
- Haferlach, T
Publication type:
Article
Fusion proteins between ligands for NKG2D and CD20-directed single-chain variable fragments sensitize lymphoma cells for natural killer cell-mediated lysis and enhance antibody-dependent cellular cytotoxicity.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 830, doi. 10.1038/leu.2011.288
By:
- Kellner, C;
- Hallack, D;
- Glorius, P;
- Staudinger, M;
- Mohseni Nodehi, S;
- de Weers, M;
- van de Winkel, J G J;
- Parren, P W H I;
- Stauch, M;
- Valerius, T;
- Repp, R;
- Humpe, A;
- Gramatzki, M;
- Peipp, M
Publication type:
Article
Favorable outcome in infants with AML after intensive first- and second-line treatment: an AML-BFM study group report.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 654, doi. 10.1038/leu.2011.267
By:
- Creutzig, U;
- Zimmermann, M;
- Bourquin, J-P;
- Dworzak, M N;
- Kremens, B;
- Lehrnbecher, T;
- von Neuhoff, C;
- Sander, A;
- von Stackelberg, A;
- Schmid, I;
- Starý, J;
- Steinbach, D;
- Vormoor, J;
- Reinhardt, D
Publication type:
Article
Management of treatment-emergent peripheral neuropathy in multiple myeloma.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 595, doi. 10.1038/leu.2011.346
By:
- Richardson, P G;
- Delforge, M;
- Beksac, M;
- Wen, P;
- Jongen, J L;
- Sezer, O;
- Terpos, E;
- Munshi, N;
- Palumbo, A;
- Rajkumar, S V;
- Harousseau, J L;
- Moreau, P;
- Avet-Loiseau, H;
- Lee, J H;
- Cavo, M;
- Merlini, G;
- Voorhees, P;
- Chng, W J;
- Mazumder, A;
- Usmani, S
Publication type:
Article
The bone marrow-expressed antimicrobial cationic peptide LL-37 enhances the responsiveness of hematopoietic stem progenitor cells to an SDF-1 gradient and accelerates their engraftment after transplantation.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 736, doi. 10.1038/leu.2011.252
By:
- Wu, W;
- Kim, C H;
- Liu, R;
- Kucia, M;
- Marlicz, W;
- Greco, N;
- Ratajczak, J;
- Laughlin, M J;
- Ratajczak, M Z
Publication type:
Article
Centrosomal targeting of tyrosine kinase activity does not enhance oncogenicity in chronic myeloproliferative disorders.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 728, doi. 10.1038/leu.2011.283
By:
- Bochtler, T;
- Kirsch, M;
- Maier, B;
- Bachmann, J;
- Klingmüller, U;
- Anderhub, S;
- Ho, A D;
- Krämer, A
Publication type:
Article
Effect of nucleophosmin1 haploinsufficiency on hematopoietic stem cells.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 853, doi. 10.1038/leu.2011.270
By:
- Raval, A;
- Kusler, B;
- Pang, W W;
- Weissman, I L;
- Mitchell, B S;
- Park, C Y
Publication type:
Article
Disparities in the prevalence, pathogenesis and progression of monoclonal gammopathy of undetermined significance and multiple myeloma between blacks and whites.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 609, doi. 10.1038/leu.2011.368
By:
- Greenberg, A J;
- Vachon, C M;
- Rajkumar, S V
Publication type:
Article
EXEL-8232, a small-molecule JAK2 inhibitor, effectively treats thrombocytosis and extramedullary hematopoiesis in a murine model of myeloproliferative neoplasm induced by MPLW515L.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 720, doi. 10.1038/leu.2011.261
By:
- Wernig, G;
- Kharas, M G;
- Mullally, A;
- Leeman, D S;
- Okabe, R;
- George, T;
- Clary, D O;
- Gilliland, D G
Publication type:
Article
Venous thromboembolism in patients with essential thrombocythemia and polycythemia vera.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 563, doi. 10.1038/leu.2011.314
By:
- Reikvam, H;
- Tiu, R V
Publication type:
Article
Polymorphism of the erythropoietin gene promotor and the development of myelodysplastic syndromes subsequent to multiple myeloma.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 844, doi. 10.1038/leu.2011.262
By:
- Landgren, O;
- Ma, W;
- Kyle, R A;
- Rajkumar, S V;
- Korde, N;
- Albitar, M
Publication type:
Article
Targeting survivin and p53 in pediatric acute lymphoblastic leukemia.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 623, doi. 10.1038/leu.2011.249
By:
- Tyner, J W;
- Jemal, A M;
- Thayer, M;
- Druker, B J;
- Chang, B H
Publication type:
Article
MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 778, doi. 10.1038/leu.2011.287
By:
- Konopleva, M;
- Milella, M;
- Ruvolo, P;
- Watts, J C;
- Ricciardi, M R;
- Korchin, B;
- McQueen, T;
- Bornmann, W;
- Tsao, T;
- Bergamo, P;
- Mak, D H;
- Chen, W;
- McCubrey, J;
- Tafuri, A;
- Andreeff, M
Publication type:
Article
NKL homeobox genes in leukemia.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 572, doi. 10.1038/leu.2011.330
By:
- Homminga, I;
- Pieters, R;
- Meijerink, J P P
Publication type:
Article
c-Myb and its target Bmi1 are required for p190BCR/ABL leukemogenesis in mouse and human cells.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 644, doi. 10.1038/leu.2011.264
By:
- Waldron, T;
- De Dominici, M;
- Soliera, A R;
- Audia, A;
- Iacobucci, I;
- Lonetti, A;
- Martinelli, G;
- Zhang, Y;
- Martinez, R;
- Hyslop, T;
- Bender, T P;
- Calabretta, B
Publication type:
Article
Downregulation of MEIS1 impairs long-term expansion of CD34<sup>+</sup> NPM1-mutated acute myeloid leukemia cells.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 848, doi. 10.1038/leu.2011.277
By:
- Woolthuis, C M;
- Han, L;
- Verkaik-Schakel, R N;
- van Gosliga, D;
- Kluin, P M;
- Vellenga, E;
- Schuringa, J J;
- Huls, G
Publication type:
Article
Heterogeneity in simvastatin-induced cytotoxicity in AML is caused by differences in Ras-isoprenylation.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 845, doi. 10.1038/leu.2011.259
By:
- van der Weide, K;
- Korthuis, P M;
- Kuipers, F;
- de Vries, E G E;
- Vellenga, E
Publication type:
Article
Significantly worse survival of patients with NIH-defined chronic graft-versus-host disease and thrombocytopenia or progressive onset type: results of a prospective study.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 746, doi. 10.1038/leu.2011.257
By:
- Kuzmina, Z;
- Eder, S;
- Böhm, A;
- Pernicka, E;
- Vormittag, L;
- Kalhs, P;
- Petkov, V;
- Stary, G;
- Nepp, J;
- Knobler, R;
- Just, U;
- Krenn, K;
- Worel, N;
- Greinix, H T
Publication type:
Article
Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 682, doi. 10.1038/leu.2011.278
By:
- Stumpel, D J P M;
- Schneider, P;
- Seslija, L;
- Osaki, H;
- Williams, O;
- Pieters, R;
- Stam, R W
Publication type:
Article
Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 615, doi. 10.1038/leu.2011.275
By:
- Bujnicki, T;
- Wilczek, C;
- Schomburg, C;
- Feldmann, F;
- Schlenke, P;
- Müller-Tidow, C;
- Schmidt, T J;
- Klempnauer, K-H
Publication type:
Article
Response to salvage therapies and outcome in patients with multiple myeloma relapsing after pomalidomide therapy.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 839, doi. 10.1038/leu.2011.279
By:
- Sinha, S;
- Lacy, M;
- Mikhael, J;
- Hayman, S;
- Buadi, F;
- Detweiler-Short, K;
- Dispenzieri, A;
- Gertz, M;
- Dingli, D;
- Rajkumar, S V;
- Kumar, S K
Publication type:
Article
Bisphosphonates as antimyeloma drugs.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 589, doi. 10.1038/leu.2011.282
By:
- Modi, N D;
- Lentzsch, S
Publication type:
Article
Notch is an essential upstream regulator of NF-κB and is relevant for survival of Hodgkin and Reed-Sternberg cells.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 806, doi. 10.1038/leu.2011.265
By:
- Schwarzer, R;
- Dörken, B;
- Jundt, F
Publication type:
Article
Extreme telomere erosion in ATM-mutated and 11q-deleted CLL patients is independent of disease stage.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 826, doi. 10.1038/leu.2011.281
By:
- Britt-Compton, B;
- Lin, T T;
- Ahmed, G;
- Weston, V;
- Jones, R E;
- Fegan, C;
- Oscier, D G;
- Stankovic, T;
- Pepper, C;
- Baird, D M
Publication type:
Article
Incidence and risk factors for bleeding in 1104 patients with essential thrombocythemia or prefibrotic myelofibrosis diagnosed according to the 2008 WHO criteria.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 716, doi. 10.1038/leu.2011.258
By:
- Finazzi, G;
- Carobbio, A;
- Thiele, J;
- Passamonti, F;
- Rumi, E;
- Ruggeri, M;
- Rodeghiero, F;
- Randi, M L;
- Bertozzi, I;
- Vannucchi, A M;
- Antonioli, E;
- Gisslinger, H;
- Buxhofer-Ausch, V;
- Gangat, N;
- Rambaldi, A;
- Tefferi, A;
- Barbui, T
Publication type:
Article
Antithymocyte globulin for acute-graft-versus-host-disease prophylaxis in patients undergoing allogeneic hematopoietic cell transplantation: a systematic review.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 582, doi. 10.1038/leu.2011.349
By:
- Kumar, A;
- Mhaskar, A R;
- Reljic, T;
- Mhaskar, R S;
- Kharfan-Dabaja, M A;
- Anasetti, C;
- Mohty, M;
- Djulbegovic, B
Publication type:
Article
Anti-leukemia activity of chaetocin via death receptor-dependent apoptosis and dual modulation of the histone methyl-transferase SUV39H1.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 662, doi. 10.1038/leu.2011.271
By:
- Chaib, H;
- Nebbioso, A;
- Prebet, T;
- Castellano, R;
- Garbit, S;
- Restouin, A;
- Vey, N;
- Altucci, L;
- Collette, Y
Publication type:
Article
Impaired bortezomib binding to mutant β5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 757, doi. 10.1038/leu.2011.256
By:
- Franke, N E;
- Niewerth, D;
- Assaraf, Y G;
- van Meerloo, J;
- Vojtekova, K;
- van Zantwijk, C H;
- Zweegman, S;
- Chan, E T;
- Kirk, C J;
- Geerke, D P;
- Schimmer, A D;
- Kaspers, G J L;
- Jansen, G;
- Cloos, J
Publication type:
Article
Immunoglobulin gene repertoire in ocular adnexal lymphomas: hints on the nature of the antigenic stimulation.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 814, doi. 10.1038/leu.2011.276
By:
- Dagklis, A;
- Ponzoni, M;
- Govi, S;
- Cangi, M G;
- Pasini, E;
- Charlotte, F;
- Vino, A;
- Doglioni, C;
- Davì, F;
- Lossos, I S;
- Ntountas, I;
- Papadaki, T;
- Dolcetti, R;
- Ferreri, A J M;
- Stamatopoulos, K;
- Ghia, P
Publication type:
Article
Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 700, doi. 10.1038/leu.2011.272
By:
- Calado, R T;
- Cooper, J N;
- Padilla-Nash, H M;
- Sloand, E M;
- Wu, C O;
- Scheinberg, P;
- Ried, T;
- Young, N S
Publication type:
Article

Found: 46