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Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype dependent.
Published in:
Pharmacogenomics Journal, 2014, v. 14, n. 2, p. 151, doi. 10.1038/tpj.2013.17
By:
- Michaud, V;
- Kreutz, Y;
- Skaar, T;
- Ogburn, E;
- Thong, N;
- Flockhart, D A;
- Desta, Z
Publication type:
Article
Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics.
Published in:
Pharmacogenomics Journal, 2013, v. 13, n. 5, p. 456, doi. 10.1038/tpj.2012.32
By:
- Ji, Y;
- Biernacka, J M;
- Hebbring, S;
- Chai, Y;
- Jenkins, G D;
- Batzler, A;
- Snyder, K A;
- Drews, M S;
- Desta, Z;
- Flockhart, D;
- Mushiroda, T;
- Kubo, M;
- Nakamura, Y;
- Kamatani, N;
- Schaid, D;
- Weinshilboum, R M;
- Mrazek, D A
Publication type:
Article
Cytochrome P450 2D6 activity predicts discontinuation of tamoxifen therapy in breast cancer patients.
Published in:
Pharmacogenomics Journal, 2009, v. 9, n. 4, p. 258, doi. 10.1038/tpj.2009.14
By:
- Rae, J. M.;
- Sikora, M. J.;
- Henry, N. L.;
- Li, L.;
- Kim, S.;
- Oesterreich, S;
- Skaar, T. C.;
- Nguyen, A. T.;
- Desta, Z.;
- Storniolo, A. M.;
- Flockhart, D. A.;
- Hayes, D. F.;
- Stearns, V.
Publication type:
Article
Pharmacokinetics and QT interval pharmacodynamics of oral haloperidol in poor and extensive metabolizers of CYP2D6.
Published in:
Pharmacogenomics Journal, 2003, v. 3, n. 2, p. 105, doi. 10.1038/sj.tpj.6500160
By:
- Desai, M;
- Tanus-Santos, J E;
- Li, L;
- Gorski, J C;
- Arefayene, M;
- Liu, Y;
- Desta, Z;
- Flockhart, D A
Publication type:
Article
Habitat use and trophic position determine mercury concentration in the straight fin barb Barbus paludinosus, a small fish species in Lake Awassa, Ethiopia.
Published in:
Journal of Fish Biology, 2008, v. 73, n. 3, p. 477, doi. 10.1111/j.1095-8649.2008.01920.x
By:
- Desta, Z.;
- Borgstrøm, R.;
- Gebremariam, Z.;
- Rosseland, B. O.
Publication type:
Article
Plasma Letrozole Concentrations in Postmenopausal Women With Breast Cancer Are Associated With CYP2A6 Genetic Variants, Body Mass Index, and Age.
Published in:
Clinical Pharmacology & Therapeutics, 2011, v. 90, n. 5, p. 693, doi. 10.1038/clpt.2011.174
By:
- Desta, Z;
- Kreutz, Y;
- Nguyen, A T;
- Li, L;
- Skaar, T;
- Kamdem, L K;
- Henry, N L;
- Hayes, D F;
- Storniolo, A M;
- Stearns, V;
- Hoffmann, E;
- Tyndale, R F;
- Flockhart, D A
Publication type:
Article
Estrogen Receptor Genotypes, Menopausal Status, and the Effects of Tamoxifen on Lipid Levels: Revised and Updated Results.
Published in:
Clinical Pharmacology & Therapeutics, 2010, v. 88, n. 5, p. 626, doi. 10.1038/clpt.2010.143
By:
- Hayes, D. F.;
- Skaar, T. C.;
- Rae, J. M.;
- Henry, N. L.;
- Nguyen, A. T.;
- Stearns, V.;
- Li, L.;
- Philips, S.;
- Desta, Z.;
- Flockhart, D. A.
Publication type:
Article
Estrogen Receptor Genotypes, Menopausal Status, and the Lipid Effects of Tamoxifen.
Published in:
Clinical Pharmacology & Therapeutics, 2008, v. 83, n. 5, p. 702, doi. 10.1038/sj.clpt.6100343
By:
- Ntukidem, N. I.;
- Nguyen, A. T.;
- Stearns, V.;
- Rehman, M.;
- Schott, A.;
- Skaar, T.;
- Jin, Y.;
- Blanche, P.;
- Li, L.;
- Lemler, S.;
- Hayden, J.;
- Krauss, R. M.;
- Desta, Z.;
- Flockhart, D. A.;
- Hayes, D. F.
Publication type:
Article
The Star-Allele Nomenclature: Retooling for Translational Genomics.
Published in:
Clinical Pharmacology & Therapeutics, 2007, v. 82, n. 3, p. 244, doi. 10.1038/sj.clpt.6100284
By:
- Robarge, J. D.;
- Li, L.;
- Desta, Z.;
- Nguyen, A.;
- Flockhart, D. A.
Publication type:
Article
Enhancing Race-Based Prescribing Precision with Pharmacogenomics.
Published in:
Clinical Pharmacology & Therapeutics, 2007, v. 81, n. 3, p. 323, doi. 10.1038/sj.clpt.6100080
By:
- Nguyen, A.;
- Desta, Z.;
- Flockhart, D. A.
Publication type:
Article
OIV-B-3.
Published in:
Clinical Pharmacology & Therapeutics, 2006, v. 79, n. 2, p. P34, doi. 10.1016/j.clpt.2005.12.120
By:
- Borges, S.;
- Desta, Z.;
- Jin, Y.;
- Li, L.;
- Skaar, T. C.;
- Flockhart, D. A.
Publication type:
Article
PII-18.
Published in:
Clinical Pharmacology & Therapeutics, 2006, v. 79, n. 2, p. P40, doi. 10.1016/j.clpt.2005.12.143
By:
- Ntukidem, N. I.;
- Li, L.;
- Rehman, M. I.;
- Skaar, T. C.;
- Jin, Y.;
- Desta, Z.;
- Storniolo, A. M.;
- Stearns, V.;
- Hayes, D. F.;
- Flockhart, D. A.
Publication type:
Article
PII-63.
Published in:
Clinical Pharmacology & Therapeutics, 2006, v. 79, n. 2, p. P52, doi. 10.1016/j.clpt.2005.12.188
By:
- Preskorn, S. H.;
- Baker, B.;
- Klick-Davis, A.;
- Ramadan, M.;
- Coyner, L.;
- Flockhart, D. A.;
- Desta, Z.;
- Yang, R.;
- Burt, T.;
- Greenblatt, D. J.
Publication type:
Article
PIII-72.
Published in:
Clinical Pharmacology & Therapeutics, 2006, v. 79, n. 2, p. P78, doi. 10.1016/j.clpt.2005.12.280
By:
- Huh, W.;
- Jones, D. R.;
- Flockhart, D. A.;
- Desta, Z.
Publication type:
Article
PI-24.
Published in:
Clinical Pharmacology & Therapeutics, 2006, v. 79, n. 2, p. P13, doi. 10.1016/j.clpt.2005.12.045
By:
- Borges, S.;
- Desta, Z.;
- Jin, Y.;
- Li, L.;
- Skaar, T. C.;
- Flockhart, D. A.
Publication type:
Article
PI-29.
Published in:
Clinical Pharmacology & Therapeutics, 2006, v. 79, n. 2, p. P15, doi. 10.1016/j.clpt.2005.12.050
By:
- Ntukidem, N. I.;
- Blanche, P.;
- Li, L.;
- Krauss, R. M.;
- Skaar, T. C.;
- Desta, Z.;
- Storniolo, A. M.;
- Stearns, V.;
- Hayes, D. F.;
- Flockhart, D. A.
Publication type:
Article
Gene expression profiles of 4-hydroxy-N-desmethyl-tamoxifen (endoxifen)- and 4-hydroxy-tamoxifen (4OHTAM)-treated human breast cancer cells determined by CDNA microarray analysis.
Published in:
Clinical Pharmacology & Therapeutics, 2004, v. 75, n. 2, p. P49, doi. 10.1016/j.clpt.2003.11.183
By:
- Lim, Y.;
- Li, L.;
- Desta, Z.;
- Rae, J. M.;
- Flockhart, D. A.;
- Skaar, T. C.
Publication type:
Article
Lack of effect of chloroquine on pupillary size in man.
Published in:
Clinical Pharmacology & Therapeutics, 2004, v. 75, n. 2, p. P64, doi. 10.1016/j.clpt.2003.11.242
By:
- Adigun, A. Q.;
- Lemma, G. L.;
- Arefayene, M.;
- Desta, Z.;
- Herbert, H.;
- Lang, L.;
- Flockhart, D. A.
Publication type:
Article
Pharmacokinetics and pharmacogenetics predict the inhibitory effects of tamoxifen on platelet aggregation.
Published in:
Clinical Pharmacology & Therapeutics, 2004, v. 75, n. 2, p. P67, doi. 10.1016/j.clpt.2003.11.251
By:
- Jin, Y.;
- Ward, B.;
- Bermes, A.;
- Storniolo, A. M.;
- Lemler, S.;
- Skaar, T.;
- Desta, Z.;
- Flockhart, D. A.
Publication type:
Article
Pharmacological characterization of 4-hydroxy-n-desmethyl-tamoxifen (ENDOXIFEN) AND 4-hydroxy-tamoxifen (4OHTAM).
Published in:
Clinical Pharmacology & Therapeutics, 2004, v. 75, n. 2, p. P19, doi. 10.1016/j.clpt.2003.11.073
By:
- Lim, Y.;
- Skaar, T. C.;
- Weatherman, R. V.;
- Desta, Z.;
- Bermes, A.;
- Flockhart, D. A.;
- Johnson, M. D.
Publication type:
Article
Correlation of pharmacogenetic genotype with steady-state metabolic profiles of tamoxifen: effect on active metabolite concentrations.
Published in:
Clinical Pharmacology & Therapeutics, 2003, v. 73, n. 2, p. P55, doi. 10.1016/S0009-9236(03)90561-3
By:
- Lee, K.;
- Desta, Z.;
- Steans, V.;
- Hayes, D.F.;
- Jones, D.R.;
- Flockhart, D.A.
Publication type:
Article
Pharmacogenetic determinant of cyclophosphamide therapy in patients with lupus nephritis.
Published in:
Clinical Pharmacology & Therapeutics, 2003, v. 73, n. 2, p. P97, doi. 10.1016/S0009-9236(03)90714-4
By:
- Arefayene, M.;
- Desta, Z.;
- Takada, K.;
- Yarboro, C.;
- Carrero, H.;
- Illei, G.;
- Flockhart, D. A.
Publication type:
Article
Atypical kinetics of CYP2B6-catalyzed reactions: Evidence for separate binding sites within the active site.
Published in:
Clinical Pharmacology & Therapeutics, 2003, v. 73, n. 2, p. P7, doi. 10.1016/S0009-9236(03)90380-8
By:
- Desta, Z.;
- Ward, B.A.;
- Flockhart, D.A.
Publication type:
Article
Efavirenz is a specific phenotyping tool for cytochrome P450 2B6: Implications for HIV therapy.
Published in:
Clinical Pharmacology & Therapeutics, 2003, v. 73, n. 2, p. P7, doi. 10.1016/S0009-9236(03)90381-X
By:
- Desta, Z.;
- Ward, B.A.;
- Hall, S.D.;
- Flockhart, D.A.
Publication type:
Article
Droperidol is predominantly metabolized by human CYP3A enzymes.
Published in:
Clinical Pharmacology & Therapeutics, 2003, v. 73, n. 2, p. P16, doi. 10.1016/S0009-9236(03)90413-9
By:
- Lemma, G.L.;
- Desta, Z.;
- Jones, D.R.;
- Gorski, J.C.;
- Hall, S.D.
Publication type:
Article
Prospects of a Meshed Electrical Distribution System Featuring Large-Scale Variable Renewable Power.
Published in:
Energies (19961073), 2018, v. 11, n. 12, p. 3399, doi. 10.3390/en11123399
By:
- Cruz, Marco R. M.;
- Fitiwi, Desta Z.;
- Santos, Sérgio F.;
- Mariano, Sílvio J. P. S.;
- Catalão, João P. S.
Publication type:
Article
Aromatase inhibitor-induced modulation of breast density: clinical and genetic effects.
Published in:
British Journal of Cancer, 2013, v. 109, n. 9, p. 2331, doi. 10.1038/bjc.2013.587
By:
- Henry, N L;
- Chan, H-P;
- Dantzer, J;
- Goswami, C P;
- Li, L;
- Skaar, T C;
- Rae, J M;
- Desta, Z;
- Khouri, N;
- Pinsky, R;
- Oesterreich, S;
- Zhou, C;
- Hadjiiski, L;
- Philips, S;
- Robarge, J;
- Nguyen, A T;
- Storniolo, A M;
- Flockhart, D A;
- Hayes, D F;
- Helvie, M A
Publication type:
Article
Implementation of a pharmacogenomics consult service to support the INGENIOUS trial.
Published in:
Clinical Pharmacology & Therapeutics, 2016, v. 100, n. 1, p. 63, doi. 10.1002/cpt.347
By:
- Eadon, MT;
- Desta, Z;
- Levy, KD;
- Decker, BS;
- Pierson, RC;
- Pratt, VM;
- Callaghan, JT;
- Rosenman, MB;
- Carpenter, JS;
- Holmes, AM;
- McDonald, CA;
- Benson, EA;
- Patil, AS;
- Vuppalanchi, R;
- Gufford, BT;
- Dave, N;
- Robarge, JD;
- Hyder, MA;
- Haas, DM;
- Kreutz, RP
Publication type:
Article
Identification and Mechanistic Investigation of Drug-Drug Interactions Associated With Myopathy: A Translational Approach.
Published in:
Clinical Pharmacology & Therapeutics, 2015, v. 98, n. 3, p. 321, doi. 10.1002/cpt.150
By:
- Han, X;
- Quinney, SK;
- Wang, Z;
- Zhang, P;
- Duke, J;
- Desta, Z;
- Elmendorf, JS;
- Flockhart, DA;
- Li, L
Publication type:
Article
Age-Related Changes in MicroRNA Expression and Pharmacogenes in Human Liver.
Published in:
Clinical Pharmacology & Therapeutics, 2015, v. 98, n. 2, p. 205, doi. 10.1002/cpt.145
By:
- Burgess, KS;
- Philips, S;
- Benson, EA;
- Desta, Z;
- Gaedigk, A;
- Gaedigk, R;
- Segar, MW;
- Liu, Y;
- Skaar, TC
Publication type:
Article
Prerequisites to Implementing a Pharmacogenomics Program in a Large Health-Care System.
Published in:
Clinical Pharmacology & Therapeutics, 2014, v. 96, n. 3, p. 307, doi. 10.1038/clpt.2014.101
By:
- Levy, K D;
- Decker, B S;
- Carpenter, J S;
- Flockhart, D A;
- Dexter, P R;
- Desta, Z;
- Skaar, T C
Publication type:
Article
Compartment-Specific Gene Regulation of the CAR Inducer Efavirenz In Vivo.
Published in:
Clinical Pharmacology & Therapeutics, 2012, v. 92, n. 1, p. 103, doi. 10.1038/clpt.2012.34
By:
- Meyer zu Schwabedissen, H E;
- Oswald, S;
- Bresser, C;
- Nassif, A;
- Modess, C;
- Desta, Z;
- Ogburn, E T;
- Marinova, M;
- Lütjohann, D;
- Spielhagen, C;
- Nauck, M;
- Kroemer, H K;
- Siegmund, W
Publication type:
Article
Impact of Efavirenz on Intestinal Metabolism and Transport: Insights From an Interaction Study With Ezetimibe in Healthy Volunteers.
Published in:
Clinical Pharmacology & Therapeutics, 2012, v. 91, n. 3, p. 506, doi. 10.1038/clpt.2011.255
By:
- Oswald, S;
- Meyer zu Schwabedissen, H E;
- Nassif, A;
- Modess, C;
- Desta, Z;
- Ogburn, E T;
- Mostertz, J;
- Keiser, M;
- Jia, J;
- Hubeny, A;
- Ulrich, A;
- Runge, D;
- Marinova, M;
- Lütjohann, D;
- Kroemer, H K;
- Siegmund, W
Publication type:
Article
Induction of CYP2C19 and CYP3A Activity Following Repeated Administration of Efavirenz in Healthy Volunteers.
Published in:
Clinical Pharmacology & Therapeutics, 2012, v. 91, n. 3, p. 475, doi. 10.1038/clpt.2011.249
By:
- Michaud, V;
- Ogburn, E;
- Thong, N;
- Aregbe, A O;
- Quigg, T C;
- Flockhart, D A;
- Desta, Z
Publication type:
Article
Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro.
Published in:
2009
By:
- Jeong S;
- Woo MM;
- Flockhart DA;
- Desta Z;
- Jeong, Seongwook;
- Woo, Margaret M;
- Flockhart, David A;
- Desta, Zeruesenay
Publication type:
journal article
Efavirenz directly modulates the oestrogen receptor and induces breast cancer cell growth.
Published in:
HIV Medicine, 2010, v. 11, n. 9, p. 603, doi. 10.1111/j.1468-1293.2010.00831.x
By:
- Sikora, M. J.;
- Rae, J. M.;
- Johnson, M. D.;
- Desta, Z.
Publication type:
Article
Clinical significance of the cytochrome P450 2C19 genetic polymorphism.
Published in:
2002
By:
- Desta, Z.;
- Zhao, X.;
- Shin, J-G.;
- Flockhart, D.A.;
- Desta, Zeruesenay;
- Zhao, Xiaojiong;
- Shin, Jae-Gook;
- Flockhart, David A
Publication type:
journal article
Selection of drugs to treat gastro-oesophageal reflux disease: the role of drug interactions.
Published in:
2000
By:
- Flockhart, David A.;
- Desta, Zeruesenay;
- Mahal, Subena K.;
- Flockhart, D A;
- Desta, Z;
- Mahal, S K
Publication type:
journal article
Population pharmacogenetic-based pharmacokinetic modeling of efavirenz, 7-hydroxy- and 8-hydroxyefavirenz.
Published in:
Journal of Clinical Pharmacology, 2014, v. 54, n. 1, p. 87, doi. 10.1002/jcph.208
By:
- Abdelhady, A.M.;
- Desta, Z.;
- Jiang, F.;
- Yeo, C.W.;
- Shin, J.G.;
- Overholser, B.R.
Publication type:
Article
Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients [corrected] [published erratum appears in J CLIN PHARMACOL 2010 Jun;50(6):725].
Published in:
2010
By:
- Borges S;
- Desta Z;
- Jin Y;
- Faouzi A;
- Robarge JD;
- Philip S;
- Nguyen A;
- Stearns V;
- Hayes D;
- Rae JM;
- Skaar TC;
- Flockhart DA;
- Li L
Publication type:
Journal Article
The role of serotonin in hot flashes after breast cancer.
Published in:
2007
By:
- Carpenter J;
- Skaar T;
- Storniolo AM;
- Desta Z;
- Johns S
Publication type:
Journal Article

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