Works matching Estrogen receptor downregulators

Results: 46

The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.15828

By:

Joseph, James D.;
Darimont, Beatrice;
Zhou, Wei;
Arrazate, Alfonso;
Young, Amy;
Ingalla, Ellen;
Walter, Kimberly;
Blake, Robert A.;
Nonomiya, Jim;
Zhengyu Guan;
Kategaya, Lorna;
Govek, Steven P.;
Lai, Andiliy G.;
Kahraman, Mehmet;
Brigham, Dan;
Sensintaffar, John;
Nhin Lu;
Gang Shao;
Jing Qian;
Grillot, Kate

Publication type:

Article

Cyclopia extracts act as selective estrogen receptor subtype downregulators in estrogen receptor positive breast cancer cell lines: Comparison to standard of care breast cancer endocrine therapies and a selective estrogen receptor agonist and antagonist.

Published in:

Frontiers in Pharmacology, 2023, v. 14, p. 1, doi. 10.3389/fphar.2023.1122031

By:

Olayoku, Folasade R.;
Verhoog, Nicolette J. D.;
Louw, Ann

Publication type:

Article

Characterization of molecular and structural determinants of selective estrogen receptor downregulators.

Published in:

Breast Cancer Research & Treatment, 2007, v. 103, n. 1, p. 37, doi. 10.1007/s10549-006-9353-2

By:

Meiyun Fan;
Emily Rickert;
Lei Chen;
Aftab, Syed;
Nephew, Kenneth;
Weatherman, Ross

Publication type:

Article

Association of human epidermal growth factor receptor 2 status with ipsilateral breast tumor recurrence and resistance to endocrine therapy.

Published in:

Molecular & Clinical Oncology, 2015, v. 3, n. 4, p. 103, doi. 10.3892/mco.2015.534

By:

MAKOTO ISHITOBI;
MIZUHO SHIBA;
TAKAHIRO NAKAYAMA;
HIROKI KOYAMA;
YASUHIRO TAMAKI

Publication type:

Article

Empirical medical therapy in idiopathic male infertility: Promise or panacea?

Published in:

Clinical & Experimental Reproductive Medicine, 2014, v. 41, n. 3, p. 108, doi. 10.5653/cerm.2014.41.3.108

By:

Jae Hung Jung;
Ju Tae Seo

Publication type:

Article

Molecular modeling studies of benzothiophene-containing derivatives as promising selective estrogen receptor downregulators: a combination of 3D-QSAR, molecular docking and molecular dynamics simulations.

Published in:

Journal of Biomolecular Structure & Dynamics, 2021, v. 39, n. 8, p. 2702, doi. 10.1080/07391102.2020.1751717

By:

Zhang, Cuihua;
Li, Qunlin;
Ren, Yujie;
Liu, Fei

Publication type:

Article

Epigenetic Mechanisms of Tamoxifen Resistance in Luminal Breast Cancer.

Published in:

Diseases, 2017, v. 5, n. 3, p. 16, doi. 10.3390/diseases5030016

By:

Abdel-Hafiz, Hany A.

Publication type:

Article

Toxicoproteomics Disclose Pesticides as Downregulators of TNF-α, IL-1β and Estrogen Receptor Pathways in Breast Cancer Women Chronically Exposed.

Published in:

Frontiers in Oncology, 2020, v. 10, p. N.PAG, doi. 10.3389/fonc.2020.01698

By:

Pizzatti, Luciana;
Kawassaki, Aedra Carla Bufalo;
Fadel, Bruna;
Nogueira, Fabio C. S.;
Evaristo, Joseph A. M.;
Woldmar, Nicole;
Teixeira, Géssica Tuani;
Da Silva, Janaína Carla;
Scandolara, Thalita Basso;
Rech, Daniel;
Candiotto, Luciano Pessôa Zanetti;
Silveira, Guilherme Ferreira;
Pavanelli, Wander Rogério;
Panis, Carolina

Publication type:

Article

Promising Therapeutic Impact of a Selective Estrogen Receptor Downregulator, Fulvestrant, as Demonstrated In Vitro upon Low-Grade Serous Ovarian Carcinoma Cell Lines.

Published in:

Current Oncology, 2022, v. 29, n. 6, p. 4020, doi. 10.3390/curroncol29060321

By:

Shanta, Kamrunnahar;
Nakayama, Kentaro;
Hossain, Mohammad Mahmud;
Razia, Sultana;
Ishibashi, Tomoka;
Ishikawa, Masako;
Yamashita, Hitomi;
Kanno, Kosuke;
Sato, Seiya;
Nakayama, Satoru;
Otsuki, Yoshiro;
Kyo, Satoru

Publication type:

Article

Molecular docking and cytotoxicity interactions of naringenin and its nao-structured lipid carriers in ERα positive breast cancer.

Published in:

Indian Journal of Biochemistry & Biophysics, 2023, v. 60, n. 2, p. 141, doi. 10.56042/ijbb.v60i2.70688

By:

S., Priyadharshini;
Swaroop, Akey Krishna;
S., Jubie;
N., Jawahar;
Divecha, Vrajesh

Publication type:

Article

Systematic identification of Ctr9 regulome in ERα-positive breast cancer.

Published in:

BMC Genomics, 2016, v. 17, p. 1, doi. 10.1186/s12864-016-3248-3

By:

Hao Zeng;
Li Lu;
Ngai Ting Chan;
Horswill, Mark;
Ahlquist, Paul;
Xuehua Zhong;
Wei Xu

Publication type:

Article

Clinical utility of fulvestrant in the treatment of breast cancer: a report on the emerging clinical evidence.

Published in:

Cancer Management & Research, 2018, v. 10, p. 3083, doi. 10.2147/CMAR.S137772

By:

Rocca, Andrea;
Maltoni, Roberta;
Bravaccini, Sara;
Donati, Caterina;
Andreis, Daniele

Publication type:

Article

Fulvestrant in advanced breast cancer: evidence to date and place in therapy.

Published in:

Therapeutic Advances in Medical Oncology, 2017, v. 9, n. 7, p. 465, doi. 10.1177/1758834017711097

By:

Boér, Katalin

Publication type:

Article

Role of fulvestrant in the management of postmenopausal breast cancer.

Published in:: Expert Review of Anticancer Therapy, 2011, v. 11, n. 11, p. 1641, doi. 10.1586/era.11.138
Publication type:: Article

Equivalent single-dose pharmacokinetics of two different dosing methods of prolonged-release fulvestrant ('Faslodex') in postmenopausal women with advanced breast cancer.

Published in:

Cancer Chemotherapy & Pharmacology, 2003, v. 52, n. 4, p. 346, doi. 10.1007/s00280-003-0643-7

By:

Robertson, John F. R.;
Harrison, M. P.

Publication type:

Article

Role of fulvestrant in the treatment of postmenopausal metastatic breast cancer patients.

Published in:

Expert Review of Clinical Pharmacology, 2016, v. 9, n. 9, p. 1153, doi. 10.1080/17512433.2016.1215243

By:

Poggio, Francesca;
Lambertini, Matteo;
Blondeaux, Eva;
Vaglica, Marina;
Levaggi, Alessia;
Pronzato, Paolo;
Del Mastro, Lucia

Publication type:

Article

Intrinsic apoptotic pathway activation increases response to anti-estrogens in luminal breast cancers.

Published in:

Cell Death & Disease, 2018, v. 9, n. 2, p. 1, doi. 10.1038/s41419-017-0072-x

By:

Williams, Michelle M.;
Lee, Linus;
Werfel, Thomas;
Joly, Meghan M. Morrison;
Hicks, Donna J.;
Rahman, Bushra;
Elion, David;
McKernan, Courtney;
Sanchez, Violeta;
Estrada, Monica V.;
Massarweh, Suleiman;
Elledge, Richard;
Duvall, Craig;
Cook, Rebecca S.

Publication type:

Article

Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells.

Published in:

Breast Cancer Research, 2025, v. 27, n. 1, p. 1, doi. 10.1186/s13058-024-01945-z

By:

Young, K. S.;
Hancock, G. R.;
Fink, E. C.;
Zigrossi, A.;
Flowers, B.;
Cooper, D. A.;
Nguyen, V. T.;
Martinez, M. C.;
Mon, K. S.;
Bosland, M.;
Zak, D. R.;
Runde, A. P.;
Sharifi, M. N.;
Kastrati, I.;
Minh, D. D. L.;
Kregel, S.;
Fanning, Sean W.

Publication type:

Article

Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER.

Published in:

2015

By:

Zekas, Erin;
Prossnitz, Eric R

Publication type:

journal article

Estrogen receptor blockade and radiation therapy cooperate to enhance the response of immunologically cold ER+ breast cancer to immunotherapy.

Published in:

Breast Cancer Research, 2023, v. 25, n. 1, p. 1, doi. 10.1186/s13058-023-01671-y

By:

O'Leary, Kathleen A.;
Bates, Amber M.;
Jin, Won Jong;
Burkel, Brian M.;
Sriramaneni, Raghava N.;
Emma, Sarah E.;
Nystuen, Erin J.;
Sumiec, Elizabeth G.;
Ponik, Suzanne M.;
Morris, Zachary S.;
Schuler, Linda A.

Publication type:

Article

Selenium Analogue of LSZ102 as a Highly Potent ER‐α Binder.

Published in:

European Journal of Organic Chemistry, 2023, v. 26, n. 27, p. 1, doi. 10.1002/ejoc.202300460

By:

Paegle, Edgars;
Arsenyan, Pavel

Publication type:

Article

The immunomodulatory effects of endocrine therapy in breast cancer.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2021, v. 40, n. 1, p. 1, doi. 10.1186/s13046-020-01788-4

By:

Huang, Huanhuan;
Zhou, Jun;
Chen, Hailong;
Li, Jiaxin;
Zhang, Chao;
Jiang, Xia;
Ni, Chao

Publication type:

Article

Differential Regulation and Targeting of Estrogen Receptor α Turnover in Invasive Lobular Breast Carcinoma.

Published in:

Endocrinology, 2020, v. 161, n. 9, p. 1, doi. 10.1210/endocr/bqaa109

By:

Sreekumar, Sreeja;
Levine, Kevin M;
Sikora, Matthew J;
Chen, Jian;
Tasdemir, Nilgun;
Carter, Dorothy;
Dabbs, David J;
Meier, Carolin;
Basudan, Ahmed;
Boone, David;
McAuliffe, Priscilla F;
Jankowitz, Rachel C;
Lee, Adrian V;
Atkinson, Jennifer M;
Oesterreich, Steffi

Publication type:

Article

Treating ER-positive breast cancer: a review of the current FDA-approved SERMs and SERDs and their mechanisms of action.

Published in:

Oncology Reviews, 2025, p. 1, doi. 10.3389/or.2025.1564642

By:

Kim, Nayoung;
Lukong, Kiven Erique

Publication type:

Article

Estrogen Receptor Signaling in the Immune System.

Published in:

Endocrine Reviews, 2023, v. 44, n. 1, p. 117, doi. 10.1210/endrev/bnac017

By:

Chakraborty, Binita;
Byemerwa, Jovita;
Krebs, Taylor;
Lim, Felicia;
Chang, Ching-Yi;
McDonnell, Donald P

Publication type:

Article

Role of SUMOylation in Full Antiestrogenicity.

Published in:

Molecular & Cellular Biology, 2012, v. 32, n. 19, p. 3823, doi. 10.1128/MCB.00290-12

By:

Hilmi, Khalid;
Hussein, Nader;
Mendoza-Sanchez, Rodrigo;
El-Ezzy, Mohamed;
Ismail, Houssam;
Durette, Chantal;
Bail, Martine;
Rozendaal, Maria Johanna;
Bouvier, Michel;
Thibault, Pierre;
Gleason, James L.;
Mader, Sylvie

Publication type:

Article

Elacestrant for ER-Positive HER2-Negative Advanced Breast Cancer.

Published in:

Annals of Pharmacotherapy, 2024, v. 58, n. 8, p. 849, doi. 10.1177/10600280231206131

By:

Hageman, Elizabeth;
Lussier, Mia E.

Publication type:

Article

Hormonal Therapy for the Treatment of Postmenopausal Breast Cancer Patients.

Published in:

Journal of Pharmacy Practice, 2008, v. 21, n. 1, p. 36, doi. 10.1177/0897190008315055

By:

Greene, Rebecca E.;
Tsang, Vivian

Publication type:

Article

Endocrine Therapy in Premenopausal Hormone Receptor Positive/Human Epidermal Growth Receptor 2 Negative Metastatic Breast Cancer: Between Guidelines and Literature.

Published in:

Oncologist, 2018, v. 23, n. 8, p. 974, doi. 10.1634/theoncologist.2018-0077

By:

Tancredi, Richard;
Furlanetto, Jenny;
Loibl, Sibylle

Publication type:

Article

Icariin attenuates high glucose-induced type IV collagen and fibronectin accumulation in glomerular mesangial cells by inhibiting transforming growth factor-β production and signalling through G protein-coupled oestrogen receptor 1.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2013, v. 40, n. 9, p. 635, doi. 10.1111/1440-1681.12143

By:

Li, Yi‐Chen;
Ding, Xuan‐Sheng;
Li, Hui‐Mei;
Zhang, Cheng

Publication type:

Article

Synthesis of C4-substituted 1,2,3,4-tetrahydroisoquinolin-6-ols as potential estrogen receptor modulators.

Published in:

ARKIVOC: Online Journal of Organic Chemistry, 2024, v. 2024, p. 1, doi. 10.24820/ark.5550190.p012.308

By:

Mabank, Tanya;
Chan Vinh Lam;
Brunsveld, Luc;
Green, Ivan R.;
van Otterlo, Willem A. L.

Publication type:

Article

Tunable and Cooperative Catalysis for Enantioselective Pictet‐Spengler Reaction with Varied Nitrogen‐Containing Heterocyclic Carboxaldehydes.

Published in:

Angewandte Chemie, 2021, v. 133, n. 46, p. 24778, doi. 10.1002/ange.202109694

By:

Chan, Yuk‐Cheung;
Sak, Marcus H.;
Frank, Scott A.;
Miller, Scott J.

Publication type:

Article

Hormonal therapy for postmenopausal breast cancer: the science of sequencing.

Published in:

Breast Cancer Research & Treatment, 2007, v. 103, n. 2, p. 149, doi. 10.1007/s10549-006-9369-7

By:

William Miller;
John Bartlett;
Peter Canney;
Mark Verrill

Publication type:

Article

Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions.

Published in:

Biomedicines, 2022, v. 10, n. 4, p. 861, doi. 10.3390/biomedicines10040861

By:

Farkas, Szidónia;
Szabó, Adrienn;
Hegyi, Anita Emőke;
Török, Bibiána;
Fazekas, Csilla Lea;
Ernszt, Dávid;
Kovács, Tamás;
Zelena, Dóra

Publication type:

Article

Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.72512

By:

Hosfield, David J.;
Weber, Sandra;
Nan Sheng Li;
Suavage, Madline;
Joiner, Carstyn F.;
Hancock, Govinda R.;
Sullivan, Emily A.;
Ndukwe, Estelle;
Han, Ross;
Cush, Sydney;
Lainé, Muriel;
Mader, Sylvie C.;
Greene, Geoffrey L.;
Fanning, Sean W.

Publication type:

Article

Cotargeting of CYP-19 (aromatase) and emerging, pivotal signalling pathways in metastatic breast cancer.

Published in:

British Journal of Cancer, 2017, v. 116, n. 1, p. 10, doi. 10.1038/bjc.2016.405

By:

Daldorff, Stine;
Mathiesen, Randi Margit Ruud;
Yri, Olav Erich;
Ødegård, Hilde Presterud;
Geisler, Jürgen

Publication type:

Article

Cotargeting of CYP-19 (aromatase) and emerging, pivotal signalling pathways in metastatic breast cancer.

Published in:

2016

By:

Daldorff, Stine;
Mathiesen, Randi Margit Ruud;
Yri, Olav Erich;
Ødegård, Hilde Presterud;
Geisler, Jürgen

Publication type:

journal article

Comprehensive Transcriptomic and Proteomic Analyses Identify a Candidate Gene Set in Cross-Resistance for Endocrine Therapy in Breast Cancer.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 18, p. N.PAG, doi. 10.3390/ijms231810539

By:

Li, Chung-Liang;
Moi, Sin-Hua;
Lin, Huei-Shan;
Hou, Ming-Feng;
Chen, Fang-Ming;
Shih, Shen-Liang;
Kan, Jung-Yu;
Kao, Chieh-Ni;
Wu, Yi-Chia;
Kao, Li-Chun;
Chen, Ying-Hsuan;
Lee, Yi-Chen;
Chiang, Chih-Po

Publication type:

Article

Oral Selective Estrogen Receptor Degraders (SERDs) as a Novel Breast Cancer Therapy: Present and Future from a Clinical Perspective.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 15, p. 7812, doi. 10.3390/ijms22157812

By:

Hernando, Cristina;
Ortega-Morillo, Belén;
Tapia, Marta;
Moragón, Santiago;
Martínez, María Teresa;
Eroles, Pilar;
Garrido-Cano, Iris;
Adam-Artigues, Anna;
Lluch, Ana;
Bermejo, Begoña;
Cejalvo, Juan Miguel

Publication type:

Article

Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence.

Published in:

Signal Transduction & Targeted Therapy, 2020, v. 5, n. 1, p. 1, doi. 10.1038/s41392-020-0199-6

By:

Wang, Qiao;
Peng, Hongling;
Qi, Xiaorong;
Wu, Min;
Zhao, Xia

Publication type:

Article

Post-marketing safety of elacestrant in breast cancer: a pharmacovigilance investigation using the FDA adverse event reporting system.

Published in:

BMC Pharmacology & Toxicology, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s40360-025-00887-2

By:

Fan, Ziyi;
Xu, Yanan;
Guo, Shuding;
Song, Bin

Publication type:

Article

MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways.

Published in:

Oncogene, 2011, v. 30, n. 9, p. 1082, doi. 10.1038/onc.2010.487

By:

Rao, X;
Di Leva, G;
Li, M;
Fang, F;
Devlin, C;
Hartman-Frey, C;
Burow, M E;
Ivan, M;
Croce, C M;
Nephew, K P

Publication type:

Article

Aromatase Inhibitors as Adjuvant Therapy for Postmenopausal Patients With Early Stage Breast Cancer.

Published in:

CA: A Cancer Journal for Clinicians, 2005, v. 55, n. 3, p. 145

By:

Kudchadkar, Ragini;
O'Regan, Ruth M.

Publication type:

Article

Emerging strategies to overcome resistance to endocrine therapy for breast cancer.

Published in:

Cancer & Metastasis Reviews, 2014, v. 33, n. 2/3, p. 791, doi. 10.1007/s10555-014-9504-6

By:

Ziauddin, M.;
Hua, Dong;
Tang, Shou-Ching

Publication type:

Article

Estrogen stimuli promote osteoblastic differentiation via the subtilisin-like proprotein convertase PACE4 in MC3T3-E1 cells.

Published in:

Journal of Bone & Mineral Metabolism, 2015, v. 33, n. 1, p. 30, doi. 10.1007/s00774-014-0567-9

By:

Kim, Hyejin;
Tabata, Atsushi;
Tomoyasu, Toshifumi;
Ueno, Tomomi;
Uchiyama, Shigeto;
Yuasa, Keizo;
Tsuji, Akihiko;
Nagamune, Hideaki

Publication type:

Article

Autophagy and senescence facilitate the development of antiestrogen resistance in ER positive breast cancer.

Published in:

Frontiers in Endocrinology, 2024, p. 1, doi. 10.3389/fendo.2024.1298423

By:

McGrath, Michael K.;
Abolhassani, Ali;
Guy, Luke;
Elshazly, Ahmed M.;
Barrett, John T.;
Mivechi, Nahid F.;
Gewirtz, David A.;
Schoenlein, Patricia V.

Publication type:

Article