Title: Telomerase activation by the E6 gene product of human papillomavirus type 16.
Authors: Klingelhutz, Aloysius J.; Foster, Scott A.
Abstract: Shows that expression of the human papillomavirus type 16 (HPV-16) E6 protein activates telomerase in early-passage human keratinocytes and mammary epithelial cells. Telomerase, a ribonucleoprotein complex linked to cell immortalization; The results which show that telomerase activation is an intrinsic, but insufficient, component of transformation by HPV.
Subjects: PAPILLOMAVIRUSES; NUCLEOPROTEINS; BIOCHEMICAL mechanism of action
Publication: Nature, 1996, Vol 380, Issue 6569, p79
ISSN: 0028-0836
Publication type: Academic Journal
DOI: 10.1038/380079a0

Telomerase activation by the E6 gene product of human papillomavirus type 16.

Klingelhutz, Aloysius J.; Foster, Scott A.